cyclacillin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, 6-aminopenicillanic acid derivatives | 632 | 3485-14-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A cyclohexylamido analog of PENICILLANIC ACID.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 97.53 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 13, 1979 | FDA | WYETH AYERST |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| CHEBI has role | CHEBI:36047 | antibacterial drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
| Bronchitis | indication | 32398004 | DOID:6132 |
| Urinary tract infectious disease | indication | 68566005 | |
| Infective otitis media | indication | 312218008 | |
| Pharyngitis | indication | 405737000 | DOID:2275 |
| Sinusitis | off-label use | 36971009 | |
| Cholangitis | off-label use | 82403002 | DOID:9446 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Infectious mononucleosis | contraindication | 271558008 | DOID:8568 |
| Pseudomembranous enterocolitis | contraindication | 397683000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.79 | acidic |
| pKa2 | 8.58 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Bacterial penicillin-binding protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
| Penicillin-binding protein 1A | Enzyme | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| 4018054 | VUID |
| N0000146395 | NUI |
| D01334 | KEGG_DRUG |
| 2968 | RXNORM |
| 4018054 | VANDF |
| CHEBI:31444 | CHEBI |
| CHEMBL1200356 | ChEMBL_ID |
| 4817 | IUPHAR_LIGAND_ID |
| 2764 | INN_ID |
| DB01000 | DRUGBANK_ID |
| 72ZJ154X86 | UNII |
| 002696 | NDDF |
| 387382002 | SNOMEDCT_US |
| 69331001 | SNOMEDCT_US |
| C0010523 | UMLSCUI |
| D003493 | MESH_DESCRIPTOR_UI |
| 19003 | PUBCHEM_CID |
Pharmaceutical products:
None