chlortetracycline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, protein-synthesis inhibitors, tetracycline derivatives | 624 | 57-62-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A TETRACYCLINE with a 7-chloro substitution.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 59.66 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 30 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.90 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 2 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.52 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 7 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 23, 1950 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Adulterated product | 36.66 | 31.90 | 3 | 4 | 32 | 34956892 |
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A01AB21 | ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Antiinfectives and antiseptics for local oral treatment |
| ATC | D06AA02 | DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE ANTIBIOTICS FOR TOPICAL USE Tetracycline and derivatives |
| ATC | J01AA03 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE TETRACYCLINES Tetracyclines |
| ATC | S01AA02 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000977 | Antiparasitic Agents |
| MeSH PA | D000981 | Antiprotozoal Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D011500 | Protein Synthesis Inhibitors |
| CHEBI has role | CHEBI:22986 | calcium ionophores |
| CHEBI has role | CHEBI:35820 | antiprotozoal drugs |
| CHEBI has role | CHEBI:36047 | antibacterial drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Trachoma | indication | 2576002 | DOID:11265 |
| Neonatal conjunctivitis | indication | 34298002 | DOID:9699 |
| Minor Bacterial Skin Infections | indication | ||
| Blepharoconjunctivitis | off-label use | 68659002 | DOID:2456 |
| Bacterial conjunctivitis | off-label use | 128350005 | DOID:9700 |
| Ocular rosacea | off-label use | 200933006 | |
| Meibomianitis | off-label use | 309779001 | |
| Infective blepharitis | off-label use | 312219000 | |
| Bacterial keratitis | off-label use | 314557000 |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cattle | Maintenance of weight gains in the presence of respiratory disease | Indication |
| Cattle | Bacterial enteritis caused by Escherichia coli | Indication |
| Cattle | Bacterial enteritis caused by Salmonella spp | Indication |
| Cattle | Bacterial pneumonia caused by Pasteurella spp | Indication |
| Cattle | Bacterial pneumonia caused by Histophilus spp | Indication |
| Cattle | Bacterial pneumonia caused by Klebsiella spp | Indication |
| Cattle | To reduce the incidence of liver abscesses | Indication |
| Cattle | Anaplasmosis caused by Anaplasma marginale | Indication |
| Chickens | Infectious synovitis caused by Mycoplasma synoviae | Indication |
| Chickens | Escherichia coli infections | Indication |
| Chickens | Prevention of coccidiosis caused by Eimeria tenella | Indication |
| Chickens | Prevention of coccidiosis caused by E necatrix | Indication |
| Chickens | Prevention of coccidiosis caused by E acervulina | Indication |
| Chickens | Prevention of coccidiosis caused by E maxima | Indication |
| Chickens | Prevention of coccidiosis caused by E brunetti | Indication |
| Chickens | Prevention of coccidiosis caused by E mivati | Indication |
| Chickens | Chronic respiratory disease caused by Mycoplasma gallisepticum | Indication |
| Chickens | Chronic respiratory disease caused by Escherichia coli | Indication |
| Ducks | Cholera caused by Pasteurella multocida | Indication |
| Psittacine Birds | Psittacosis caused by Chlamydia psittaci | Indication |
| Sheep | Reducing the incidence of (vibrionic) abortion caused by Campylobacter fetus infection | Indication |
| Swine | Reduction of the incidence of cervical abscesses | Indication |
| Swine | Bacterial swine enteritis | Indication |
| Swine | Maintenance of weight gains in the presence of atrophic rhinitis | Indication |
| Swine | Bacterial pneumonia caused by Pasteurella multocida | Indication |
| Swine | Reduction in the incidence of cervical lymphadenitis (jowl abscesses) caused by group E Streptococci | Indication |
| Swine | Proliferative enteropathies (ileitis) caused by Lawsonia intracellularis | Indication |
| Swine | Leptospirosis caused by Leptospira pomona | Indication |
| Swine | Reducing the incidence of (vibrionic) abortion caused by Campylobacter fetus infection | Indication |
| Turkeys | Infectious synovitis caused by Mycoplasma | Indication |
| Turkeys | Hexamitiasis caused by Hexamita meleagridis | Indication |
| Turkeys | Control of complicating bacterial organisms associated with bluecomb | Indication |
| Turkeys | Reduction of mortality caused by paratyphoid caused by Salmonella typhimurium | Indication |
| Cattle | Maintenance of weight gains in the presence of respiratory disease | Indication |
| Cattle | Bacterial enteritis caused by Escherichia coli | Indication |
| Cattle | Bacterial enteritis caused by Salmonella spp | Indication |
| Cattle | Bacterial pneumonia caused by Pasteurella spp | Indication |
| Cattle | Bacterial pneumonia caused by Histophilus spp | Indication |
| Cattle | Bacterial pneumonia caused by Klebsiella spp | Indication |
| Cattle | Reduction of the incidence of liver abscesses | Indication |
| Cattle | Anaplasmosis caused by Anaplasma marginale | Indication |
| Chickens | Infectious synovitis caused by Mycoplasma synoviae | Indication |
| Chickens | Reduction of mortality caused by Escherichia coli infections | Indication |
| Chickens | Prevention of coccidiosis caused by Eimeria tenella | Indication |
| Chickens | Prevention of coccidiosis caused by E necatrix | Indication |
| Chickens | Prevention of coccidiosis caused by E acervulina | Indication |
| Chickens | Prevention of coccidiosis caused by E maxima | Indication |
| Chickens | Prevention of coccidiosis caused by E brunetti | Indication |
| Chickens | Prevention of coccidiosis caused by E mivati | Indication |
| Chickens | Chronic respiratory disease caused by Mycoplasma gallisepticum | Indication |
| Chickens | Chronic respiratory disease caused by Escherichia coli | Indication |
| Ducks | Cholera caused by Pasteurella multocida | Indication |
| Psittacine Birds | Psittacosis caused by Chlamydia psittaci | Indication |
| Sheep | Reducing the incidence of (vibrionic) abortion caused by Campylobacter fetus infection | Indication |
| Swine | Reduction of the incidence of cervical abscesses | Indication |
| Swine | Bacterial swine enteritis | Indication |
| Swine | Maintenance of weight gains in the presence of atrophic rhinitis | Indication |
| Swine | Bacterial pneumonia caused by Pasteurella multocida | Indication |
| Swine | Reduction in the incidence of cervical lymphadenitis (jowl abscesses) caused by group E Streptococci | Indication |
| Swine | Proliferative enteropathies (ileitis) caused by Lawsonia intracellularis | Indication |
| Swine | Leptospirosis caused by Leptospira pomona | Indication |
| Swine | Reducing the incidence of (vibrionic) abortion caused by Campylobacter fetus infection | Indication |
| Turkeys | Infectious synovitis caused by Mycoplasma | Indication |
| Turkeys | Hexamitiasis caused by Hexamita meleagridis | Indication |
| Turkeys | Control of complicating bacterial organisms associated with bluecomb | Indication |
| Turkeys | Reduction of mortality caused by paratyphoid caused by Salmonella typhimurium | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Aureomix S 40/40 Granular | Zoetis Inc. | 2 |
| Aureo S 700 Granular, Aureo S 700 | Zoetis Inc. | 2 |
| Amprol Plus and Aureomycin | Zoetis Inc. | 3 |
| AUREOMIX S 700-A | Zoetis Inc. | 2 |
| AUREOMIX S 700-D | Zoetis Inc. | 2 |
| Aureomix S 700-G | Zoetis Inc. | 2 |
| Aureomix S 700-E | Zoetis Inc. | 2 |
| Aureomix 700-F | Zoetis Inc. | 2 |
| Aureomix S 700-C | Zoetis Inc. | 2 |
| AUREOMIX S 700-B | Zoetis Inc. | 2 |
| AUREOMIX S 700-H | Zoetis Inc. | 2 |
| Deccox and Aureomycin | Zoetis Inc. | 2 |
| COYDEN plus CTC | Huvepharma EOOD | 2 |
| ChlorMax 50, ChlorMax 65, ChlorMax 70, ChlorMax 100, Micro CTC | Zoetis Inc. | 1 |
| Chloratet 100, Chloratet 50, Chloratet 90 | Pharmgate Inc. | 1 |
| Aureomycin 50 Granular, Aureomycin 50 Granular A, Aureomycin 70 Granular, Aureomycin 80 Granular, Aureomycin 90 Granular, Aureomycin 90 Meal, Aureomycin 100 Granular | Zoetis Inc. | 1 |
| PfiChlor 50, PfiChlor 70, PfiChlor 100 | Zoetis Inc. | 1 |
| Chloronex Sulmet | Huvepharma EOOD | 2 |
| Chlortetracycline Hydrochloride Tablets | Huvepharma EOOD | 1 |
| Bulk Chlortetracycline Hydrochloride | Zoetis Inc. | 1 |
| Aureomycin Soluble Powder | Zoetis Inc. | 1 |
| Aureomycin Soluble Oblets | Huvepharma EOOD | 1 |
| CHLORTETRACYCLINE SOLUBLE POWDER | Pharmgate Inc. | 1 |
| Fermycin Soluble | Phibro Animal Health Corp. | 1 |
| CHLORTET-SOLUBLE-O | Pharmgate Inc. | 1 |
| Chloronex | Pharmgate Inc. | 1 |
| Chlortetracycline hydrochloride soluble powder | Pharmgate Inc. | 1 |
| Calf Scour Boluses, Chlortetracycline Pneumonia | Cronus Pharma Specialities India Private Limited | 1 |
| CTC Bisulfate Soluble Powder | Cronus Pharma Specialities India Private Limited | 1 |
| CLTC 10, CLTC 20, CLTC 30, CLTC 50, CLTC 70 | Phibro Animal Health Corp. | 1 |
| CLTC 50 MR, CLTC 100 MR | Phibro Animal Health Corp. | 1 |
| Robenz and Aureomycin | Zoetis Inc. | 2 |
| PfiChlor 100S | Zoetis Inc. | 1 |
| Aureomycin / Coban | Zoetis Inc. | 2 |
| Pennchlor S 40/40 | Pharmgate Inc. | 2 |
| Pennchlor 50, Pennchlor 50 G, Pennchlor 90 G, Pennchlor 100 G, Pennchlor 100 Hi-Flo | Pharmgate Inc. | 1 |
| Bio-Cox/Aureomycin | Zoetis Inc. | 2 |
| Aureomycin and Cattlyst | Zoetis Inc. | 2 |
| Denagard plus CTC | Elanco US Inc. | 2 |
| BMD and ChlorMax | Zoetis Inc. | 2 |
| Chlormax and Deccox | Zoetis Inc. | 2 |
| Aureomycin / Deccox | Zoetis Inc. | 2 |
| Aureomycin and Bovatec | Zoetis Inc. | 2 |
| MGA and Aureomycin | Zoetis Inc. | 2 |
| MGA and Bovatec and Aureomycin | Zoetis Inc. | 3 |
| Aureo S 700 and Bovatec | Zoetis Inc. | 3 |
| Aureomycin / Sacox | Huvepharma EOOD | 2 |
| Chlortetracycline HCL Soluble Powder | Quo Vademus LLC | 1 |
| BMD-25, -30, -40, -50, -60, or -75 / Aureomycin -50, -70, -80, -90 or -100 | Zoetis Inc. | 2 |
| Bio-Cox / ChlorMax | Zoetis Inc. | 2 |
| ChlorMax / Sacox | Zoetis Inc. | 2 |
| ChlorMax / Coban | Zoetis Inc. | 2 |
| Pennchlor 64 | Pharmgate Inc. | 1 |
| Pennchlor S | Pharmgate Inc. | 2 |
| Pennchlor / Coban | Pharmgate Inc. | 2 |
| Pennchlor / Denagard | Pharmgate Inc. | 2 |
| Pennchlor / Bio-Cox | Pharmgate Inc. | 2 |
| BMD Pennchlor | Pharmgate Inc. | 2 |
| Pennchlor / Deccox | Pharmgate Inc. | 2 |
| Aureomycin | Pharmgate Inc. | 1 |
| Deracin 50 Meal, Deracin 90 Meal, Deracin 100 Meal | Pharmgate Inc. | 1 |
| Deracin plus Bovatec | Pharmgate Inc. | 2 |
| Deccox plus Deracin | Pharmgate Inc. | 2 |
| Denagard and Deracin | Pharmgate Inc. | 2 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.26 | acidic |
| pKa2 | 6.96 | acidic |
| pKa3 | 7.57 | acidic |
| pKa4 | 11.92 | acidic |
| pKa5 | 12.66 | acidic |
| pKa6 | 13.29 | acidic |
| pKa7 | 9.49 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Enzyme | IC50 | 4 | CHEMBL | |||||
| Major prion protein | Surface antigen | WOMBAT-PK | |||||||
| Protein-arginine deiminase type-4 | Enzyme | IC50 | 4 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019677 | VUID |
| N0000147769 | NUI |
| D02255 | KEGG_DRUG |
| 1306093 | RXNORM |
| 4017878 | VANDF |
| 4019677 | VANDF |
| C0008293 | UMLSCUI |
| CHEBI:27644 | CHEBI |
| CTC | PDB_CHEM_ID |
| CHEMBL404520 | ChEMBL_ID |
| CHEMBL2146063 | ChEMBL_ID |
| D002751 | MESH_DESCRIPTOR_UI |
| DB09093 | DRUGBANK_ID |
| 236 | INN_ID |
| 64-72-2 | SECONDARY_CAS_RN |
| 57122-99-3 | SECONDARY_CAS_RN |
| WCK1KIQ23Q | UNII |
| 54675777 | PUBCHEM_CID |
| 4431 | MMSL |
| 618 | MMSL |
| 002741 | NDDF |
| 003592 | NDDF |
| 373509001 | SNOMEDCT_US |
| 57538001 | SNOMEDCT_US |
| 7737009 | SNOMEDCT_US |
| 96319006 | SNOMEDCT_US |
| 96320000 | SNOMEDCT_US |
| CHEMBL2146100 | ChEMBL_ID |
| CHEMBL2106006 | ChEMBL_ID |
| 27823-62-7 | SECONDARY_CAS_RN |
Pharmaceutical products:
None