chlortetracycline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antibiotics, protein-synthesis inhibitors, tetracycline derivatives	624	57-62-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: chlortetracycline aureociclin aureomicina aureomycin chlorocyclinum chlortetracyclin chlortetracycline hydrochloride chlortetracycline HCl chlortetracycline calcium complex chlortetracycline calcium chlortetracycline bisulfate	A TETRACYCLINE with a 7-chloro substitution. Molecular weight: 478.88 Formula: C22H23ClN2O8 CLOGP: -0.49 LIPINSKI: 1 HAC: 10 HDO: 6 TPSA: 181.62 ALOGS: -3.27 ROTB: 2 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

chlortetracycline
aureociclin
aureomicina
aureomycin
chlorocyclinum
chlortetracyclin
chlortetracycline hydrochloride
chlortetracycline HCl
chlortetracycline calcium complex
chlortetracycline calcium
chlortetracycline bisulfate

A TETRACYCLINE with a 7-chloro substitution.

Molecular weight: 478.88
Formula: C22H23ClN2O8
CLOGP: -0.49
LIPINSKI: 1
HAC: 10
HDO: 6
TPSA: 181.62
ALOGS: -3.27
ROTB: 2

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
1	g	O

ADMET properties:

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Property	Value	Reference
t_half (Half-life)	7 hours	Lombardo F, Berellini G, Obach RS
MRTD (Maximum Recommended Therapeutic Daily Dose)	59.66 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	30 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance)	2 mL/min/kg	Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)	0.90 L/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.52 %	Lombardo F, Berellini G, Obach RS

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Approvals:

Date	Agency	Company	Orphan
Jan. 23, 1950	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Adulterated product	36.66	31.90	3	4	32	34956892

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FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	A01AB21	ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Antiinfectives and antiseptics for local oral treatment
ATC	D06AA02	DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE ANTIBIOTICS FOR TOPICAL USE Tetracycline and derivatives
ATC	J01AA03	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE TETRACYCLINES Tetracyclines
ATC	S01AA02	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics
CHEBI has role	CHEBI:22986	calcium ionophores
CHEBI has role	CHEBI:35820	antiprotozoal drugs
CHEBI has role	CHEBI:36047	antibacterial drugs
MeSH PA	D000900	Anti-Bacterial Agents
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000977	Antiparasitic Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Trachoma	indication	2576002	DOID:11265
Neonatal conjunctivitis	indication	34298002	DOID:9699
Minor Bacterial Skin Infections	indication
Blepharoconjunctivitis	off-label use	68659002	DOID:2456
Bacterial conjunctivitis	off-label use	128350005	DOID:9700
Ocular rosacea	off-label use	200933006
Meibomianitis	off-label use	309779001
Infective blepharitis	off-label use	312219000
Bacterial keratitis	off-label use	314557000

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🐶 Veterinary Drug Use

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Species	Use	Relation
Cattle	Maintenance of weight gains in the presence of respiratory disease	Indication
Cattle	Bacterial enteritis caused by Escherichia coli	Indication
Cattle	Bacterial enteritis caused by Salmonella spp	Indication
Cattle	Bacterial pneumonia caused by Pasteurella spp	Indication
Cattle	Bacterial pneumonia caused by Histophilus spp	Indication
Cattle	Bacterial pneumonia caused by Klebsiella spp	Indication
Cattle	To reduce the incidence of liver abscesses	Indication
Cattle	Anaplasmosis caused by Anaplasma marginale	Indication
Chickens	Infectious synovitis caused by Mycoplasma synoviae	Indication
Chickens	Escherichia coli infections	Indication

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🐶 Veterinary products

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Product	Applicant	Ingredients
Amprol Plus and Aureomycin	Zoetis Inc.	3
Aureo S 700 and Bovatec	Zoetis Inc.	3
Aureo S 700 Granular, Aureo S 700	Zoetis Inc.	2
Aureomix 700-F	Zoetis Inc.	2
Aureomix S 40/40 Granular	Zoetis Inc.	2
AUREOMIX S 700-A	Zoetis Inc.	2
AUREOMIX S 700-B	Zoetis Inc.	2
Aureomix S 700-C	Zoetis Inc.	2
AUREOMIX S 700-D	Zoetis Inc.	2
Aureomix S 700-E	Zoetis Inc.	2

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Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.26	acidic
pKa2	6.96	acidic
pKa3	7.57	acidic
pKa4	11.92	acidic
pKa5	12.66	acidic
pKa6	13.29	acidic
pKa7	9.49	Basic

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Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	Enzyme	P27815	PDE4A_HUMAN	IC50	4	CHEMBL
Major prion protein	Surface antigen	P04156	PRIO_HUMAN			WOMBAT-PK
Protein-arginine deiminase type-4	Enzyme	Q9UM07	PADI4_HUMAN	IC50	4	CHEMBL

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External reference:

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ID	Source
002741	NDDF
003592	NDDF
1306093	RXNORM
236	INN_ID
27823-62-7	SECONDARY_CAS_RN
373509001	SNOMEDCT_US
4017878	VANDF
4019677	VUID
4019677	VANDF
4431	MMSL

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Pharmaceutical products:

None