chlorpropamide indications/contra

Stem definitionDrug idCAS RN
antihyperglycaemics 622 94-20-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • chlorpropamide
  • chlorodiabina
  • chloronase
  • chloropropamide
  • chlorpropamid
A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)
  • Molecular weight: 276.74
  • Formula: C10H13ClN2O3S
  • CLOGP: 2.35
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 75.27
  • ALOGS: -3.25
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.38 g O

Approvals:

DateAgencyCompanyOrphan
Oct. 28, 1958 FDA PFIZER

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 15.37 0 3 9 14315 3371532

Pharmacologic Action:

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SourceCodeDescription
ATC A10BB02 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sulfonylureas
FDA EPC N0000175608 Sulfonylurea
FDA Chemical/Ingredient N0000008054 Sulfonylurea Compounds
CHEBI has role CHEBI:35526 hypoglycemic agent
MeSH PA D007004 Hypoglycemic Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352
Asthenia contraindication 13791008
Hepatic porphyria contraindication 55056006 DOID:3133
Heart disease contraindication 56265001 DOID:114
Hemolytic anemia contraindication 61261009 DOID:583
Glucose-6-phosphate dehydrogenase deficiency anemia contraindication 62403005 DOID:2862
Hypopituitarism contraindication 74728003 DOID:9406
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007 DOID:9993
Primary adrenocortical insufficiency contraindication 373662000 DOID:13774
Surgical procedure contraindication 387713003
Breastfeeding (mother) contraindication 413712001
Traumatic injury contraindication 417746004
Fever greater than 100.4 Fahrenheit contraindication 426000000
Prolonged-Severe Nausea and Vomiting contraindication
Diabetes insipidus off-label use 15771004 DOID:12388

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.92 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sulfonylurea receptor 1, Kir6.2 Ion channel BLOCKER Kd 5.05 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Solute carrier family 22 member 6 Transporter Ki 4.40 CHEMBL

External reference:

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IDSource
4017841 VUID
N0000146198 NUI
C0008287 UMLSCUI
6801 IUPHAR_LIGAND_ID
D00271 KEGG_DRUG
CHEMBL498 ChEMBL_ID
DB00672 DRUGBANK_ID
2727 PUBCHEM_CID
4017841 VANDF
4361 MMSL
N0000006948 NDFRT
N0000146198 NDFRT
2404 RXNORM
000910 NDDF
111154004 SNOMEDCT_US
386991003 SNOMEDCT_US
4430 MMSL
d00042 MMSL
CHEBI:3650 CHEBI
D002747 MESH_DESCRIPTOR_UI
WTM2C3IL2X UNII
790 INN_ID

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Chlorpropamide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0197 TABLET 100 mg ORAL ANDA 11 sections
Chlorpropamide HUMAN PRESCRIPTION DRUG LABEL 1 0378-0210 TABLET 250 mg ORAL ANDA 11 sections
Chlorpropamide HUMAN PRESCRIPTION DRUG LABEL 1 55289-066 TABLET 250 mg ORAL ANDA 11 sections