chlorphentermine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anorexics 618 461-78-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • chlorphentermine hydrochloride
  • chlorphentermine
  • clorfentermina
  • desopimon
  • teramine
  • chlorphentermine HCl
A sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of DEXTROAMPHETAMINE. It has been implicated in lipid storage disorders and pulmonary hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1223)
  • Molecular weight: 183.68
  • Formula: C10H14ClN
  • CLOGP: 2.85
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 26.02
  • ALOGS: -3.24
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 0 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 17 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 4.87 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
None FDA PARKE DAVIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013566 Sympathomimetics

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Obesity indication 414916001 DOID:9970
Heart valve disorder contraindication 368009 DOID:4079
Alcoholism contraindication 7200002
Glaucoma contraindication 23986001 DOID:1686
Feeling agitated contraindication 24199005
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Mild pre-eclampsia contraindication 41114007
Conduction disorder of the heart contraindication 44808001
Diabetes mellitus type 1 contraindication 46635009 DOID:9744
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Substance abuse contraindication 66214007
Psychotic disorder contraindication 69322001
Pulmonary hypertension contraindication 70995007 DOID:6432
Secondary glaucoma contraindication 95717004
Angina pectoris contraindication 194828000
Edema contraindication 267038008
Syncope contraindication 271594007
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Hypertensive urgency contraindication 443482000




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.92 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter SUBSTRATE Ki 6.47 WOMBAT-PK CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 5.40 WOMBAT-PK

External reference:

IDSource
D03476 KEGG_DRUG
151-06-4 SECONDARY_CAS_RN
220218 RXNORM
C0008283 UMLSCUI
CHEBI:3646 CHEBI
CHEMBL1201269 ChEMBL_ID
DB01556 DRUGBANK_ID
CHEMBL1200595 ChEMBL_ID
D002745 MESH_DESCRIPTOR_UI
10007 PUBCHEM_CID
1055 INN_ID
NHW07912O7 UNII
13941 MMSL
001872 NDDF
004775 NDDF
9643009 SNOMEDCT_US

Pharmaceutical products:

None