chloroxine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	611	773-76-2

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

chloroxine
chlofucid
chloroxyquinoline
clofuzid
dichlorohydroxyquinoline
dichloroquinolinol
dichloroxin
endiaron
quixalin
quinolor

Molecular weight: 214.05
Formula: C9H5Cl2NO
CLOGP: 3.34
LIPINSKI: 0
HAC: 2
HDO: 1
TPSA: 33.12
ALOGS: -3.19
ROTB: 0

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	89 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
Oct. 19, 1976	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D000900	Anti-Bacterial Agents
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000935	Antifungal Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Seborrheic dermatitis	indication	50563003	DOID:8741
Pityriasis simplex	indication	200767005
Denuded skin	contraindication	418242004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.75	acidic
pKa2	2.74	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Arachidonate 5-lipoxygenase	Enzyme	P09917	LOX5_HUMAN		IC50	5.44		CHEMBL
Arachidonate 15-lipoxygenase	Enzyme	P16050	LOX15_HUMAN		IC50	5.62		CHEMBL
Arachidonate 12-lipoxygenase, 12S-type	Enzyme	P18054	LOX12_HUMAN		IC50	5.72		CHEMBL
Arachidonate 15-lipoxygenase, type II	Enzyme	O15296	LX15B_HUMAN		IC50	4.55		CHEMBL
Botulinum neurotoxin type A	Enzyme		BXA1_CLOBO		IC50	4.94		CHEMBL
Replicase polyprotein 1ab	Enzyme		R1AB_SARS2		Kd	5.34		CHEMBL

External reference:

ID	Source
4018664	VUID
N0000146975	NUI
D03472	KEGG_DRUG
20875	RXNORM
4018664	VANDF
C0055461	UMLSCUI
CHEMBL1200596	ChEMBL_ID
DB01243	DRUGBANK_ID
CHEMBL3833358	ChEMBL_ID
2722	PUBCHEM_CID
C004357	MESH_SUPPLEMENTAL_RECORD_UI
2I8BD50I8B	UNII
4422	MMSL
003147	NDDF
126148000	SNOMEDCT_US
424004006	SNOMEDCT_US

Pharmaceutical products:

None