chlorothiazide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diuretics, chlorothiazide derivatives	609	58-94-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: chlorothiazide chlorothiazide sodium	A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) Molecular weight: 295.71 Formula: C7H6ClN3O4S2 CLOGP: -0.29 LIPINSKI: 0 HAC: 7 HDO: 2 TPSA: 118.69 ALOGS: -2.85 ROTB: 1 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

chlorothiazide
chlorothiazide sodium

A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)

Molecular weight: 295.71
Formula: C7H6ClN3O4S2
CLOGP: -0.29
LIPINSKI: 0
HAC: 7
HDO: 2
TPSA: 118.69
ALOGS: -2.85
ROTB: 1

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.50	g	O
0.50	g	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	4	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.70 mg/mL	Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine)	92 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	112.60 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	13 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
Sept. 4, 1958	FDA	OAK PHARMS AKORN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pulmonary vein stenosis	35.55	27.11	5	1081	83	63487853
Rhinovirus infection	33.91	27.11	9	1077	4520	63483416
Respiratory failure	30.71	27.11	20	1066	101838	63386098
Hypervolaemia	30.28	27.11	13	1073	28400	63459536
Hypoxia	29.13	27.11	16	1070	59776	63428160

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory failure	42.23	26.29	34	1292	108538	34847067
Hyperparathyroidism secondary	41.34	26.29	10	1316	1558	34954047
Pulmonary hypertension	35.99	26.29	17	1309	20907	34934698
Respiratory distress	32.67	26.29	19	1307	35646	34919959
Serotonin syndrome	27.68	26.29	14	1312	19919	34935686

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory distress	50.86	24.23	27	2176	58312	79683873
Respiratory failure	50.58	24.23	41	2162	180870	79561315
Hospitalisation	41.26	24.23	28	2175	94208	79647977
Hyperparathyroidism secondary	39.23	24.23	10	2193	2650	79739535
Pulmonary vein stenosis	37.11	24.23	6	2197	159	79742026
Hypoxia	36.68	24.23	27	2176	103216	79638969
Pulmonary hypertension	35.65	24.23	20	2183	48060	79694125
Pulmonary arterial hypertension	33.10	24.23	16	2187	28350	79713835
Rhinovirus infection	32.29	24.23	11	2192	7942	79734243
Hypervolaemia	29.60	24.23	17	2186	42673	79699512
Catheterisation cardiac	27.54	24.23	9	2194	5719	79736466
Tracheitis	24.63	24.23	6	2197	1322	79740863
Cardiac operation	24.61	24.23	8	2195	5004	79737181

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C03AA04	CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, THIAZIDES Thiazides, plain
ATC	C03AB04	CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, THIAZIDES Thiazides and potassium in combination
ATC	C03AH01	CARDIOVASCULAR SYSTEM DIURETICS LOW-CEILING DIURETICS, THIAZIDES Thiazides, combinations with psycholeptics and/or analgesics
FDA CS	M0471776	Thiazides
FDA PE	N0000175359	Increased Diuresis
FDA EPC	N0000175419	Thiazide Diuretic
CHEBI has role	CHEBI:35498	diuretics
CHEBI has role	CHEBI:35674	antihypertensive drugs
MeSH PA	D000959	Antihypertensive Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D004232	Diuretics
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D045283	Natriuretic Agents
MeSH PA	D049993	Sodium Chloride Symporter Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763
Chronic heart failure	indication	48447003
Edema	indication	267038008
Hypertensive urgency	indication	443482000
Edema due to Nephrotic Syndrome	indication
Edema due to Hepatic Cirrhosis	indication
Hypertension with Left Ventricular Hypertrophy	indication
Pulmonary Edema due to Chronic Heart Failure	indication
Peripheral Edema due to Chronic Heart Failure	indication
Nephrogenic diabetes insipidus	off-label use	111395007	DOID:12387
Calcium renal calculus	off-label use	427649000
Anuria	contraindication	2472002	DOID:2983
Bronchospasm	contraindication	4386001
Suicidal thoughts	contraindication	6471006
Psoriasis	contraindication	9014002	DOID:8893
Peptic ulcer	contraindication	13200003	DOID:750
Hypercholesterolemia	contraindication	13644009
Hyperkalemia	contraindication	14140009
Chronic disease of respiratory system	contraindication	17097001
Metabolic acidosis, normal anion gap, acidifying salts	contraindication	18104000
Jaundice	contraindication	18165001
Cirrhosis of liver	contraindication	19943007	DOID:5082
Secondary angle-closure glaucoma	contraindication	21571006
Electroconvulsive therapy	contraindication	23835007
Acute vomiting	contraindication	23971007
Complete atrioventricular block	contraindication	27885002
Hypovolemia	contraindication	28560003
Acute cerebrovascular insufficiency	contraindication	29322000
Obstruction of bile duct	contraindication	30144000
Parkinsonism	contraindication	32798002
Dehydration	contraindication	34095006
Depressive disorder	contraindication	35489007
Hyperuricemia	contraindication	35885006	DOID:1920
Sick sinus syndrome	contraindication	36083008	DOID:13884
Acute hepatitis	contraindication	37871000
Immunosuppression	contraindication	38013005
Anaphylaxis	contraindication	39579001
Angioedema	contraindication	41291007	DOID:1558
Hypokalemia	contraindication	43339004
Diabetes mellitus type 2	contraindication	44054006	DOID:9352
Conduction disorder of the heart	contraindication	44808001
Low blood pressure	contraindication	45007003
Diabetes mellitus type 1	contraindication	46635009	DOID:9744
Sinus bradycardia	contraindication	49710005
Cough	contraindication	49727002
Acidosis	contraindication	51387008
Syndrome of inappropriate vasopressin secretion	contraindication	55004003	DOID:3401
Systemic lupus erythematosus	contraindication	55464009	DOID:9074
Sympathectomy	contraindication	57071006
Acute nephropathy	contraindication	58574008
Hepatic failure	contraindication	59927004
Aortic valve stenosis	contraindication	60573004	DOID:1712
Chronic bronchitis	contraindication	63480004	DOID:6132
Ulcerative colitis	contraindication	64766004	DOID:8577
Hypercalcemia	contraindication	66931009	DOID:12678
Hyperparathyroidism	contraindication	66999008	DOID:13543
Benign intracranial hypertension	contraindication	68267002	DOID:11459
Hypochloremic alkalosis	contraindication	70134007
Hepatic coma	contraindication	72836002	DOID:12550
Diabetes mellitus	contraindication	73211009	DOID:9351
Wolff-Parkinson-White pattern	contraindication	74390002	DOID:384
Transplantation	contraindication	77465005
Chronic idiopathic constipation	contraindication	82934008
Hereditary angioneurotic edema	contraindication	82966003	DOID:14735
Oliguria	contraindication	83128009
Epilepsy	contraindication	84757009	DOID:1826
Megaloblastic anemia due to folate deficiency	contraindication	85649008	DOID:14026
Pulmonary emphysema	contraindication	87433001
Cardiogenic shock	contraindication	89138009
Hyponatremia	contraindication	89627008
Gout	contraindication	90560007	DOID:13189
Kidney disease	contraindication	90708001	DOID:557
Myasthenia gravis	contraindication	91637004	DOID:437
Kidney stone	contraindication	95570007
Disorder of connective tissue	contraindication	105969002	DOID:65
Diabetic renal disease	contraindication	127013003
Disorder of muscle	contraindication	129565002	DOID:423
Liver function tests abnormal	contraindication	166603001
Hypomagnesemia	contraindication	190855004
Angina pectoris	contraindication	194828000
Partial atrioventricular block	contraindication	195039008
Second degree atrioventricular block	contraindication	195042002
Decompensated cardiac failure	contraindication	195111005
Asthma	contraindication	195967001	DOID:2841
Acute hepatic failure	contraindication	197270009
Acute pancreatitis	contraindication	197456007	DOID:2913
Impaired renal function disorder	contraindication	197663003
Cerebrovascular accident	contraindication	230690007
Hypertrophic cardiomyopathy	contraindication	233873004	DOID:11984
Disease of liver	contraindication	235856003	DOID:409
Hypoglycemic disorder	contraindication	237630007
Disorder of electrolytes	contraindication	237840007
Lupus erythematosus and erythema multiforme-like syndrome	contraindication	238926009
Rhabdomyolysis	contraindication	240131006
Raynaud's phenomenon	contraindication	266261006
Calculus in biliary tract	contraindication	266474003
Anemia	contraindication	271737000	DOID:2355
Neonatal hyperbilirubinemia	contraindication	281610001
Pregnancy, function	contraindication	289908002
Renal artery stenosis	contraindication	302233006
Pheochromocytoma	contraindication	302835009
Hypertriglyceridemia	contraindication	302870006
Neutropenic disorder	contraindication	303011007	DOID:1227
Bone marrow depression	contraindication	307762000
Severe chronic obstructive pulmonary disease	contraindication	313299006
Right ventricular failure	contraindication	367363000
Surgical procedure	contraindication	387713003
Peripheral arterial occlusive disease	contraindication	399957001
Peripheral vascular disease	contraindication	400047006
Severe diarrhea	contraindication	409587002
Autoimmune hemolytic anemia	contraindication	413603009	DOID:718
Disorder of coronary artery	contraindication	414024009
Myocardial ischemia	contraindication	414795007	DOID:3393
Myocardial infarction in recovery phase	contraindication	418044006
Porphyria	contraindication	418470004
Intraoperative floppy iris syndrome	contraindication	418801006
Poor metabolizer due to cytochrome p450 CYP2D6 variant	contraindication	423629005
Slow acetylator due to N-acetyltransferase enzyme variant	contraindication	425079005
Azotemia	contraindication	445009001
Smokes tobacco daily	contraindication	449868002
Acute exacerbation of asthma	contraindication	708038006
Severe Cerebrovascular Disease	contraindication
Hemodialysis with High-Flux Membrane	contraindication
Head and Neck Angioedema	contraindication
First Degree Atrioventricular Heart Block	contraindication
Intestinal Angioedema	contraindication
Severe Aortic Valve Stenosis	contraindication

🐶 Veterinary Drug Use

Species	Use	Relation
Dogs	Congestive heart failure	Indication
Dogs	Renal edema	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Diuril Tablet	Boehringer lngelheim Animal Health USA Inc.	1
Diuril	Boehringer lngelheim Animal Health USA Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	6.53	acidic
pKa2	9.74	acidic
pKa3	4.58	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Solute carrier family 12 member 3	Transporter	P55017	S12A3_HUMAN	INHIBITOR	A2	5.43		WOMBAT-PK	CHEMBL
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN					WOMBAT-PK

External reference:

ID	Source
4017731	VUID
N0000146099	NUI
D00519	KEGG_DRUG
7085-44-1	SECONDARY_CAS_RN
2396	RXNORM
4017731	VANDF
4017732	VANDF
C0008273	UMLSCUI
CHEBI:3640	CHEBI
CHEMBL842	ChEMBL_ID
DB00880	DRUGBANK_ID
CHEMBL1200616	ChEMBL_ID
D002740	MESH_DESCRIPTOR_UI
2720	PUBCHEM_CID
4835	IUPHAR_LIGAND_ID
636	INN_ID
77W477J15H	UNII
169210	MMSL
3950	MMSL
4419	MMSL
4420	MMSL
d00190	MMSL
002292	NDDF
002293	NDDF
372782002	SNOMEDCT_US
5786005	SNOMEDCT_US
8252004	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Chlorothiazide Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0517-1820	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	500 mg	INTRAVENOUS	ANDA	24 sections
Chlorothiazide Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	17478-419	INJECTION	500 mg	INTRAVENOUS	NDA authorized generic	25 sections
Chlorothiazide Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	17478-419	INJECTION	500 mg	INTRAVENOUS	NDA authorized generic	25 sections
chlorothiazide sodium	HUMAN PRESCRIPTION DRUG LABEL	1	25021-305	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	500 mg	INTRAVENOUS	ANDA	25 sections
chlorothiazide sodium	HUMAN PRESCRIPTION DRUG LABEL	1	25021-305	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	500 mg	INTRAVENOUS	ANDA	25 sections
CHLOROTHIAZIDE SODIUM	Human Prescription Drug Label	1	47335-330	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	500 mg	INTRAVENOUS	ANDA	21 sections
Chlorothiazide	Human Prescription Drug Label	1	63323-658	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	500 mg	INTRAVENOUS	ANDA	13 sections
Chlorothiazide	Human Prescription Drug Label	1	63323-658	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	500 mg	INTRAVENOUS	ANDA	13 sections
Chlorothiazide	Human Prescription Drug Label	1	63323-658	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	500 mg	INTRAVENOUS	ANDA	13 sections
Chlorothiazide	Human Prescription Drug Label	1	63323-658	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	500 mg	INTRAVENOUS	ANDA	13 sections
Chlorothiazide	Human Prescription Drug Label	1	63323-658	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	500 mg	INTRAVENOUS	ANDA	13 sections
Chlorothiazide	Human Prescription Drug Label	1	63323-658	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	500 mg	INTRAVENOUS	ANDA	13 sections
DIURIL	HUMAN PRESCRIPTION DRUG LABEL	1	65649-311	SUSPENSION	250 mg	ORAL	NDA	23 sections
DIURIL	HUMAN PRESCRIPTION DRUG LABEL	1	65649-311	SUSPENSION	250 mg	ORAL	NDA	23 sections
Sodium Diuril	HUMAN PRESCRIPTION DRUG LABEL	1	76478-711	INJECTION	0.50 mg	INTRAVENOUS	NDA	24 sections
Sodium Diuril	HUMAN PRESCRIPTION DRUG LABEL	1	76478-711	INJECTION	0.50 mg	INTRAVENOUS	NDA	24 sections
Sodium Diuril	HUMAN PRESCRIPTION DRUG LABEL	1	76478-711	INJECTION	0.50 mg	INTRAVENOUS	NDA	24 sections