racecadotril indications/contra

Stem definitionDrug idCAS RN
endopeptidase inhibitors 60 81110-73-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ecadotril
  • acetorphan
  • racecadotril
  • cadotril
  • redotil
A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
  • Molecular weight: 385.48
  • Formula: C21H23NO4S
  • CLOGP: 3.85
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 72.47
  • ALOGS: -5.34
  • ROTB: 11

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1993 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC A07XA04 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
OTHER ANTIDIARRHEALS
Other antidiarrheals
MeSH PA D000930 Antidiarrheals
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D011480 Protease Inhibitors

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Acute diarrhea indication 409966000

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Neprilysin Enzyme INHIBITOR IC50 9 CHEMBL KEGG DRUG
Angiotensin-converting enzyme Enzyme IC50 6.50 CHEMBL
Endothelin-converting enzyme 1 Unclassified IC50 8.10 CHEMBL
Thermolysin Unclassified IC50 5.02 CHEMBL
Neprilysin Unclassified IC50 8.40 CHEMBL
Neprilysin Enzyme IC50 8.32 CHEMBL
Angiotensin-converting enzyme Enzyme IC50 6.38 CHEMBL
Neprilysin Unclassified IC50 8.21 CHEMBL

External reference:

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IDSource
4025231 VUID
N0000179029 NUI
C0050461 UMLSCUI
D08464 KEGG_DRUG
CHEMBL10247 ChEMBL_ID
6XSR933SRK UNII
6896 INN_ID
112573-73-6 SECONDARY_CAS_RN
4025231 VANDF
N0000171763 NDFRT
N0000179029 NDFRT
006079 NDDF
16738 RXNORM
699272003 SNOMEDCT_US
714679008 SNOMEDCT_US
107751 PUBCHEM_CID
CHEMBL1516410 ChEMBL_ID
C049331 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL2103772 ChEMBL_ID
D015244 MESH_DESCRIPTOR_UI
DB11696 DRUGBANK_ID
DB08626 DRUGBANK_ID

Pharmaceutical products:

None