(S)-nitrendipine indications/contra

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 6 80873-62-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • (S)-nitrendipine
  • (-)-Nitrendipine
  • Molecular weight: 360.37
  • Formula: C18H20N2O6
  • CLOGP: 3.73
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 1
  • TPSA: 110.45
  • ALOGS: -4.41
  • ROTB: 7

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

None

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.37 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-dependent L-type calcium channel subunit alpha-1D Ion channel BLOCKER IC50 8.40 IUPHAR IUPHAR
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Intermediate conductance calcium-activated potassium channel protein 4 Ion channel BLOCKER IC50 7.60 IUPHAR
Voltage-dependent L-type calcium channel subunit alpha-1F Ion channel NEGATIVE MODULATOR IC50 6 IUPHAR
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel NEGATIVE MODULATOR IC50 6 IUPHAR
Voltage-dependent L-type calcium channel subunit alpha-1S Ion channel NEGATIVE MODULATOR IC50 6 IUPHAR

External reference:

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IDSource
2334 IUPHAR_LIGAND_ID
CHEMBL251230 ChEMBL_ID
157702 PUBCHEM_CID
CHEBI:135522 CHEBI

Pharmaceutical products:

None