acetophenazine indications/contra

Stem definitionDrug idCAS RN
59 2751-68-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • acetofenazine
  • acetofenazine maleate
  • acetophenazine
  • acetophenazine maleate
  • tindal maleate
  • tindal
major descriptor (73-85); minor descriptor (64-72); on-line search PHENOTHIAZINES (64-85); Index Medicus search PHENOTHIAZINES (64-72); ACETOPHENAZINE (73-85); RN given refers to parent cpd
  • Molecular weight: 411.56
  • Formula: C23H29N3O2S
  • CLOGP: 2.91
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 47.02
  • ALOGS: -3.84
  • ROTB: 7

Drug dosage:

DoseUnitRoute
50 mg O

Approvals:

DateAgencyCompanyOrphan
April 5, 1961 FDA SCHERING

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC N05AB07 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Phenothiazines with piperazine structure
CHEBI has role CHEBI:37930 phenothiazine antipsychotic drug

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Psychotic disorder indication 69322001
Alcoholism contraindication 7200002
Organophosphate poisoning contraindication 8260003
Weight gain finding contraindication 8943002
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Chronic disease of respiratory system contraindication 17097001
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Orthostatic hypotension contraindication 28651003
Torsades de pointes contraindication 31722008
Parkinsonism contraindication 32798002 DOID:13548
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Extrapyramidal disease contraindication 76349003
Hyperglycemia contraindication 80394007 DOID:4195
Epilepsy contraindication 84757009 DOID:1826
Leukopenia contraindication 84828003 DOID:615
Stupor contraindication 89458003
Tardive dyskinesia contraindication 102449007
Prolonged QT interval contraindication 111975006
Acute disease of cardiovascular system contraindication 128487001
Angina pectoris contraindication 194828000
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Benign prostatic hyperplasia contraindication 266569009 DOID:2883
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Coma contraindication 371632003
At risk for aspiration contraindication 371736008
Visual impairment contraindication 397540003
Breastfeeding (mother) contraindication 413712001
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Congenital long QT syndrome contraindication 442917000
Carcinoma of female breast contraindication 447782002

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.21 Basic
pKa2 4.21 Basic
pKa3 1.82 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR ANTAGONIST DRUGBANK CHEMBL
Androgen receptor Transcription factor Ki 6.10 CHEMBL

External reference:

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IDSource
4019593 VUID
N0000179028 NUI
C0050458 UMLSCUI
D00788 KEGG_DRUG
3P5HNU5JTC UNII
5714-00-1 SECONDARY_CAS_RN
DB01063 DRUGBANK_ID
4019593 VANDF
N0000147689 NDFRT
N0000179028 NDFRT
16735 RXNORM
35281007 SNOMEDCT_US
004592 NDDF
1026 INN_ID
CHEMBL1085 ChEMBL_ID
17676 PUBCHEM_CID
C100162 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL2360079 ChEMBL_ID
CHEBI:2401 CHEBI

Pharmaceutical products:

None