acetohydroxamic acid indications/contra

Stem definitionDrug idCAS RN
58 546-88-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • acetohydroxamic acid
  • acetohydroximic acid
  • acetylhydroxamic acid
  • N-acetylhydroxylamine
  • N-hydroxyacetamide
  • N-Acetyl hydroxyacetamide
urease inhibitor
  • Molecular weight: 75.07
  • Formula: C2H5NO2
  • CLOGP: -1.59
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 49.33
  • ALOGS: 0.83
  • ROTB: 0

Drug dosage:

DoseUnitRoute
0.75 g O

Approvals:

DateAgencyCompanyOrphan
May 31, 1983 FDA MISSION PHARMA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC G04BX03 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
UROLOGICALS
Other urologicals
FDA EPC N0000175611 Urease Inhibitor
FDA MoA N0000175087 Urease Inhibitors
MeSH PA D004791 Enzyme Inhibitors

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Urinary tract infectious disease indication 68566005
Struvite Renal Calculi indication
Alcoholism contraindication 7200002
Acute nephropathy contraindication 58574008
Hemolytic anemia contraindication 61261009 DOID:583
Phlebitis contraindication 61599003 DOID:864
Leukopenia contraindication 84828003 DOID:615
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.38 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 2 Enzyme IC50 4.33 CHEMBL
Bacterial urease Enzyme INHIBITOR CHEMBL CHEMBL
Urease Enzyme IC50 4.76 CHEMBL

External reference:

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IDSource
CHEBI:27777 CHEBI
DB00551 DRUGBANK_ID
4018901 VUID
N0000147195 NUI
C0050451 UMLSCUI
D00220 KEGG_DRUG
4RZ82L2GY5 UNII
5491 INN_ID
CHEMBL734 ChEMBL_ID
4018901 VANDF
N0000147195 NDFRT
N0000006036 NDFRT
d01433 MMSL
4124 MMSL
16728 RXNORM
387426003 SNOMEDCT_US
74819009 SNOMEDCT_US
001242 NDDF
C006358 MESH_SUPPLEMENTAL_RECORD_UI
1990 PUBCHEM_CID

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Lithostat HUMAN PRESCRIPTION DRUG LABEL 1 0178-0500 TABLET 250 mg ORAL NDA 17 sections