cefaloridine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, cefalosporanic acid derivatives 573 50-59-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cephaloridine
  • cefaloridine
  • cefaloridin
  • cephalomycine
A cephalosporin antibiotic.
  • Molecular weight: 415.48
  • Formula: C19H17N3O4S2
  • CLOGP: -5.45
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 93.42
  • ALOGS: -5.09
  • ROTB: 6

Drug dosage:

DoseUnitRoute
3 g P

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 206.30 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Hosey CM, Chan R, Benet LZ
Vd (Volume of distribution) 0.46 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.80 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.50 hours Lombardo F, Berellini G, Obach RS
S (Water solubility) 20 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01DB02 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
First-generation cephalosporins
CHEBI has role CHEBI:36047 antibacterial drugs
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.83 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
N0000008008 NUI
D01075 KEGG_DRUG
2233 RXNORM
C0007727 UMLSCUI
CHEBI:3537 CHEBI
CHEMBL316157 ChEMBL_ID
DB09008 DRUGBANK_ID
12189 IUPHAR_LIGAND_ID
5773 PUBCHEM_CID
002713 NDDF
28588009 SNOMEDCT_US
702746007 SNOMEDCT_US
D002509 MESH_DESCRIPTOR_UI
1910 INN_ID
LVZ1VC61HB UNII

Pharmaceutical products:

None