DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
cefaloridine ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
antibiotics, cefalosporanic acid derivatives
573
50-59-9
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
cephaloridine
cefaloridine
cefaloridin
cephalomycine
A cephalosporin antibiotic.
Molecular weight: 415.48
Formula: C19H17N3O4S2
CLOGP: -5.45
LIPINSKI: 0
HAC: 7
HDO: 1
TPSA: 93.42
ALOGS: -5.09
ROTB: 6
Drug dosage:
Dose
Unit
Route
3
g
P
ADMET properties:
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Property
Value
Reference
CL (Clearance)
3.30 mL/min/kg
Lombardo F, Berellini G, Obach RS
BDDCS (Biopharmaceutical Drug Disposition Classification System)
3
Hosey CM, Chan R, Benet LZ
MRTD (Maximum Recommended Therapeutic Daily Dose)
206.30 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
S (Water solubility)
20 mg/mL
Bocci G, Oprea TI, Benet LZ
t_half (Half-life)
1.50 hours
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.80 %
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
0.46 L/kg
Lombardo F, Berellini G, Obach RS
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Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
J01DB02
ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
First-generation cephalosporins
CHEBI has role
CHEBI:36047
antibacterial drugs
MeSH PA
D000900
Anti-Bacterial Agents
MeSH PA
D000890
Anti-Infective Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
2.83
acidic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
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entries
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ID
Source
002713
NDDF
12189
IUPHAR_LIGAND_ID
1910
INN_ID
2233
RXNORM
28588009
SNOMEDCT_US
5773
PUBCHEM_CID
702746007
SNOMEDCT_US
C0007727
UMLSCUI
CHEBI:3537
CHEBI
CHEMBL316157
ChEMBL_ID
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Pharmaceutical products:
None
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cefaloridine