cefroxadine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, cefalosporanic acid derivatives 557 51762-05-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • CGP-9000
  • CGP 9000
  • cefroxadin
  • cefroxadine
orally active, broad spectrum cephalosporin
  • Molecular weight: 365.40
  • Formula: C16H19N3O5S
  • CLOGP: -1.95
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 3
  • TPSA: 121.96
  • ALOGS: -2.57
  • ROTB: 5

Drug dosage:

DoseUnitRoute
2.10 g O

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.17 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.78 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.10 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.74 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01DB11 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
First-generation cephalosporins

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.42 acidic
pKa2 7.56 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01528 KEGG_DRUG
C0108941 UMLSCUI
CHEBI:31379 CHEBI
CHEMBL3186538 ChEMBL_ID
DB11367 DRUGBANK_ID
C012671 MESH_SUPPLEMENTAL_RECORD_UI
5284529 PUBCHEM_CID
4722 INN_ID
B908C4MV2R UNII
010923 NDDF

Pharmaceutical products:

None