cefprozil indications/contra

Stem definitionDrug idCAS RN
antibiotics, cefalosporanic acid derivatives 556 92665-29-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cefprozil
  • cefprozile
  • cephprozyl
  • cefprozil hydrate
  • Molecular weight: 389.43
  • Formula: C18H19N3O5S
  • CLOGP: -1.87
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 4
  • TPSA: 132.96
  • ALOGS: -3.42
  • ROTB: 5

Drug dosage:

DoseUnitRoute
1 g O

Approvals:

DateAgencyCompanyOrphan
Dec. 23, 1991 FDA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC J01DC10 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Second-generation cephalosporins
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:36047 antibacterial drug
FDA EPC N0000175488 Cephalosporin Antibacterial
FDA Chemical/Ingredient N0000011161 Cephalosporins

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Acute otitis media indication 3110003
Infection of skin AND/OR subcutaneous tissue indication 19824006
Bronchitis indication 32398004 DOID:6132
Streptococcal tonsillitis indication 41582007
Upper respiratory infection indication 54150009 DOID:10459
Acute bacterial sinusitis indication 75498004
Tonsillitis indication 90176007 DOID:10456
Acute Moraxella catarrhalis bronchitis indication 195722003
Acute bacterial bronchitis indication 233598009
Streptococcus pyogenes infection indication 302809008
Infective otitis media indication 312218008
Infection due to Staphylococcus aureus indication 406602003
Acute exacerbation of chronic bronchitis indication 425748003
Moraxella Catarrhalis Acute Otitis Media indication
Pneumococcal Acute Otitis Media indication
Haemophilus Influenzae Acute Otitis Media indication
Streptococcus Pneumoniae Bronchitis indication
Haemophilus Influenzae Chronic Bronchitis indication
Streptococcus Pneumoniae Chronic Bronchitis indication
Moraxella Catarrhalis Chronic Bronchitis indication
Haemophilus Influenzae Bronchitis indication
Acute nephropathy contraindication 58574008
Factor II deficiency contraindication 73975000
Pseudomembranous enterocolitis contraindication 397683000 DOID:0060185
Pyrexia of unknown origin off-label use 7520000

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.7 acidic
pKa2 9.72 acidic
pKa3 7.63 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Penicillin-binding protein 1A Enzyme WOMBAT-PK

External reference:

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IDSource
4020058 VUID
N0000148083 NUI
C0053882 UMLSCUI
D00261 KEGG_DRUG
CHEMBL276568 ChEMBL_ID
4W0459ZA4V UNII
121123-17-9 SECONDARY_CAS_RN
73619 MMSL
N0000148083 NDFRT
N0000004502 NDFRT
d00073 MMSL
4382 MMSL
19552 RXNORM
4020058 VANDF
387538005 SNOMEDCT_US
96054007 SNOMEDCT_US
003623 NDDF
5281006 PUBCHEM_CID
DB01150 DRUGBANK_ID
CHEMBL3184906 ChEMBL_ID
CHEMBL3301800 ChEMBL_ID
C052018 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:3506 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 0093-1077 TABLET, FILM COATED 250 mg ORAL ANDA 14 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 0093-1078 TABLET, FILM COATED 500 mg ORAL ANDA 14 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 0781-5043 TABLET, FILM COATED 250 mg ORAL ANDA 14 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 0781-5044 TABLET, FILM COATED 500 mg ORAL ANDA 14 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 0781-6202 POWDER, FOR SUSPENSION 125 mg ORAL ANDA 14 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 0781-6203 POWDER, FOR SUSPENSION 250 mg ORAL ANDA 14 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 16714-396 POWDER, FOR SUSPENSION 125 mg ORAL ANDA 14 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 16714-397 POWDER, FOR SUSPENSION 250 mg ORAL ANDA 14 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 16714-398 TABLET, FILM COATED 250 mg ORAL ANDA 14 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 16714-399 TABLET, FILM COATED 500 mg ORAL ANDA 14 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 42043-262 POWDER, FOR SUSPENSION 125 mg ORAL ANDA 14 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 42043-263 POWDER, FOR SUSPENSION 250 mg ORAL ANDA 14 sections
CEFPROZIL HUMAN PRESCRIPTION DRUG LABEL 1 52959-300 TABLET 500 mg ORAL ANDA 14 sections
CEFPROZIL HUMAN PRESCRIPTION DRUG LABEL 1 53217-031 TABLET 500 mg ORAL ANDA 14 sections
CEFPROZIL HUMAN PRESCRIPTION DRUG LABEL 1 54868-5756 TABLET 500 mg ORAL ANDA 14 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 54868-5757 POWDER, FOR SUSPENSION 250 mg ORAL ANDA 14 sections
CEFPROZIL HUMAN PRESCRIPTION DRUG LABEL 1 55648-713 TABLET, FILM COATED 500 mg ORAL ANDA 13 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 55700-294 TABLET, FILM COATED 500 mg ORAL ANDA 13 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 55700-455 TABLET, FILM COATED 500 mg ORAL ANDA 13 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 57237-034 POWDER, FOR SUSPENSION 125 mg ORAL ANDA 14 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 57237-035 POWDER, FOR SUSPENSION 250 mg ORAL ANDA 14 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 57237-036 TABLET, FILM COATED 250 mg ORAL ANDA 14 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 57237-037 TABLET, FILM COATED 500 mg ORAL ANDA 14 sections
CEFPROZIL HUMAN PRESCRIPTION DRUG LABEL 1 57297-402 POWDER, FOR SUSPENSION 250 mg ORAL ANDA 14 sections
CEFPROZIL HUMAN PRESCRIPTION DRUG LABEL 1 57297-404 TABLET 500 mg ORAL ANDA 14 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 60505-2532 TABLET, FILM COATED 250 mg ORAL ANDA 12 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 60505-2533 TABLET, FILM COATED 500 mg ORAL ANDA 12 sections
CEFPROZIL HUMAN PRESCRIPTION DRUG LABEL 1 64679-713 TABLET, FILM COATED 500 mg ORAL ANDA 14 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 65862-068 TABLET, FILM COATED 250 mg ORAL ANDA 14 sections
Cefprozil HUMAN PRESCRIPTION DRUG LABEL 1 65862-069 TABLET, FILM COATED 500 mg ORAL ANDA 14 sections