gefapixant 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| purinoreceptor (P2X) antagonists | 5519 | 1015787-98-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Gefapixant is a selective, non-narcotic P2X3 receptor antagonist being approved for the treatment of refractory chronic cough or unexplained chronic cough.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 20, 2022 | PMDA | MSD K.K. |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R05DB29 | RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS Other cough suppressants |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Refractory chronic cough | indication | 2561000112106 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| P2X purinoceptor 3 | Ion channel | ANTAGONIST | IC50 | 7.37 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| AF9 | PDB_CHEM_ID |
| CHEMBL3716057 | ChEMBL_ID |
| C000597312 | MESH_SUPPLEMENTAL_RECORD_UI |
| 9540 | IUPHAR_LIGAND_ID |
| 2310299-91-1 | SECONDARY_CAS_RN |
| DB15097 | DRUGBANK_ID |
| C5139827 | UMLSCUI |
| CHEMBL4594278 | ChEMBL_ID |
| D11349 | KEGG_DRUG |
| 10642 | INN_ID |
| 24764487 | PUBCHEM_CID |
| 6K6L7E3F1L | UNII |
Pharmaceutical products:
None