cefoselis 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, cefalosporanic acid derivatives 545 122841-10-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cefoselis
  • wincef
  • cefoselis sulfate
  • Molecular weight: 522.56
  • Formula: C19H22N8O6S2
  • CLOGP: -9.67
  • LIPINSKI: 2
  • HAC: 14
  • HDO: 4
  • TPSA: 205.10
  • ALOGS: -3.41
  • ROTB: 9

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.77 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.90 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK2,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK1,GRK2,GRK3,GSK3B,ITK,JAK1,JAK2,JAK3,KIT,MAP2K6,MAP3K1,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MAPKAPK5,MARK4,MELK,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PIM3,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 73
kinase-selectivity-class AXL,EIF2AK3,GRK2,MAP2K6,MAP3K14,MAPK12,MAPK7,STK33,TEK 9
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.73 acidic
pKa2 13.31 acidic
pKa3 4.73 Basic
pKa4 3.34 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02232 KEGG_DRUG
C0965645 UMLSCUI
CHEBI:3496 CHEBI
CHEMBL2105940 ChEMBL_ID
C079769 MESH_SUPPLEMENTAL_RECORD_UI
12034 IUPHAR_LIGAND_ID
7171 INN_ID
122841-12-7 SECONDARY_CAS_RN
0B50MLU3H1 UNII
5748845 PUBCHEM_CID

Pharmaceutical products:

None