delgocitinib 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| Janus kinase inhibitors, antineoplastics | 5426 | 1263774-59-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Delgocitinib, a janus kinase (JAK) inhibitor, is being approved for the treatment of inflammatory skin conditions. Delgocitinib inhibited the activation of inflammatory cells, such as T cells, B cells, monocytes and mast cells, in vitro and inhibited Th1-, Th2- and Th17-type cytokine production from both T cells and non-T cells.
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Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 23, 2020 | PMDA | Japan Tobacco |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
| CHEBI has role | CHEBI:50748 | antipsoriatic drug |
| CHEBI has role | CHEBI:59010 | antiseborrheics |
| CHEBI has role | CHEBI:76617 | BTK inhibitor |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Atopic dermatitis | indication | 24079001 | DOID:3310 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK3 | Kinase | INHIBITOR | IC50 | 7.89 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Tyrosine-protein kinase JAK1 | Kinase | INHIBITOR | IC50 | 8.55 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Tyrosine-protein kinase JAK2 | Kinase | INHIBITOR | IC50 | 8.58 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Non-receptor tyrosine-protein kinase TYK2 | Kinase | INHIBITOR | IC50 | 7.24 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Tyrosine-protein kinase Lck | Kinase | IC50 | 5.24 | CHEMBL | |||||
| Rho-associated protein kinase 2 | Kinase | INHIBITOR | IC50 | 6.58 | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| D11046 | KEGG_DRUG |
| 9L0Q8KK220 | UNII |
| C5226741 | UMLSCUI |
| CHEBI:167600 | CHEBI |
| FHX | PDB_CHEM_ID |
| CHEMBL4297507 | ChEMBL_ID |
| 50914062 | PUBCHEM_CID |
| DB16133 | DRUGBANK_ID |
| 9619 | IUPHAR_LIGAND_ID |
| C000621572 | MESH_SUPPLEMENTAL_RECORD_UI |
| 10574 | INN_ID |
Pharmaceutical products:
None