dotinurad 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
urate transporter inhibitors 5425 1285572-51-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dotinurad
  • urece
  • FYU-981
Dotinurad, a novel selective urate reabsorption inhibitor, reduces serum uric acid levels by selectively inhibiting urate transporter 1 (URAT1), which is expressed on the proximal renal tubules and is responsible for reabsorption of uric acid.
  • Molecular weight: 358.19
  • Formula: C14H9Cl2NO4S
  • CLOGP: 1.99
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 74.68
  • ALOGS: -3.96
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 23, 2020 PMDA Fuji Yakuhin

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018501 Antirheumatic Agents
MeSH PA D006074 Gout Suppressants
MeSH PA D014528 Uricosuric Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hyperuricemia indication 35885006 DOID:1920
Gout indication 90560007 DOID:13189




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Solute carrier family 22 member 12 Transporter INHIBITOR IC50 7.43 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
ATP-binding cassette sub-family G member 2 Transporter INHIBITOR IC50 5.38 SCIENTIFIC LITERATURE
Solute carrier family 22 member 6 Transporter INHIBITOR IC50 5.39 SCIENTIFIC LITERATURE
Solute carrier family 22 member 8 Transporter INHIBITOR IC50 5.88 SCIENTIFIC LITERATURE
Cytochrome P450 2C9 Enzyme INHIBITOR IC50 5.24 SCIENTIFIC LITERATURE

External reference:

IDSource
D11071 KEGG_DRUG
305EB53128 UNII
C5238059 UMLSCUI
CHEMBL4594446 ChEMBL_ID
51349053 PUBCHEM_CID
DB16145 DRUGBANK_ID
11389 IUPHAR_LIGAND_ID
C000706811 MESH_SUPPLEMENTAL_RECORD_UI
10438 INN_ID

Pharmaceutical products:

None