bulevirtide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antiviral, peptides and glycopeptides	5417	2012558-47-1

Description:

Molecule	Description
Molfile Synonyms: bulevirtide bulevirtide acetate hepcludex myrcludex B	Bulevirtide is an antiviral medicine used to treat chronic (long-term) hepatitis delta virus (HDV) infection in adults with compensated liver disease (when the liver is damaged but is still able to work), when the presence of viral RNA (genetic material) has been confirmed by blood tests. Bulevirtide blocks the entry of HBV and HDV into hepatocytes by binding to and inactivating NTCP, a bile salt liver transporter serving as essential HBV/HDV entry receptor. Molecular weight: 5398.95 Formula: C248H355N65O72 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 2162.54 ALOGS: ROTB: None

Molecule

Description

Molfile

Synonyms:

bulevirtide
bulevirtide acetate
hepcludex
myrcludex B

Bulevirtide is an antiviral medicine used to treat chronic (long-term) hepatitis delta virus (HDV) infection in adults with compensated liver disease (when the liver is damaged but is still able to work), when the presence of viral RNA (genetic material) has been confirmed by blood tests. Bulevirtide blocks the entry of HBV and HDV into hepatocytes by binding to and inactivating NTCP, a bile salt liver transporter serving as essential HBV/HDV entry receptor.

Molecular weight: 5398.95
Formula: C248H355N65O72
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 2162.54
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
July 31, 2020	EMA	MYR GmbH

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	J05AX28	ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Other antivirals

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Chronic viral hepatitis B with hepatitis D	indication	235869004
Chronic infection caused by Hepatitis D virus	indication	735451005

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sodium/bile acid cotransporter	Transporter	Q14973	NTCP_HUMAN	INHIBITOR	IC50	6.49		DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D11877	KEGG_DRUG
WKM56H3TLB	UNII
406461-66-3	SECONDARY_CAS_RN
C5139876	UMLSCUI
CHEMBL4297711	ChEMBL_ID
DB15248	DRUGBANK_ID
CHEMBL4297792	ChEMBL_ID
C571888	MESH_SUPPLEMENTAL_RECORD_UI
12775	IUPHAR_LIGAND_ID
DB14853	DRUGBANK_ID
019120	NDDF
019121	NDDF
C000718249	MESH_SUPPLEMENTAL_RECORD_UI
10692	INN_ID

Pharmaceutical products:

None