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mefuparib 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| poly-ADP-ribose polymerase inhibitors | 5378 | None |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Poly(ADP-ribose) Polymerase Inhibitors
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:62913 | EC 2.4.2.30 (NAD<small><sup>+</small></sup> ADP-ribosyltransferase) inhibitor |
| CHEBI has role | CHEBI:68495 | apoptosis inducer |
| CHEBI has role | CHEBI:149553 | anticoronaviral agent |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.94 | acidic |
| pKa2 | 9.23 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Poly [ADP-ribose] polymerase 2 | Enzyme | INHIBITOR | IC50 | 8.72 | SCIENTIFIC LITERATURE | ||||
| Poly [ADP-ribose] polymerase 1 | Enzyme | INHIBITOR | IC50 | 8.49 | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| 9NN2OZ1YX4 | UNII |
| 1449746-00-2 | SECONDARY_CAS_RN |
| 71488522 | PUBCHEM_CID |
| C000626298 | MESH_SUPPLEMENTAL_RECORD_UI |
| C4705074 | UMLSCUI |
| CHEBI:167899 | CHEBI |
| IQM | PDB_CHEM_ID |
| 1392502-82-7 | SECONDARY_CAS_RN |
Pharmaceutical products:
None