Stem definition | Drug id | CAS RN |
---|---|---|
hypoxia inducible factor (HIF) prolyl hydroxylase inhibitors | 5371 | 808118-40-3 |
Dose | Unit | Route |
---|---|---|
43 | mg | O |
None
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 18, 2021 | EMA | ASTELLAS PHARMA EUROPE B.V. | |
Sept. 20, 2019 | PMDA | Astellas Pharma Inc. |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | B03XA05 | BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS OTHER ANTIANEMIC PREPARATIONS Other antianemic preparations |
CHEBI has role | CHEBI:102248 | EC 1.14.11.29 inhibitors |
CHEBI has role | CHEBI:132365 | protocollagen hydroxylase inhibitor |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Refractory anemia (clinical) | indication | 109996008 | |
Anemia in chronic kidney disease | indication | 707323002 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 3.34 | acidic |
pKa2 | 7.78 | acidic |
pKa3 | 12.33 | acidic |
pKa4 | 4.24 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Egl nine homolog 1 | Enzyme | INHIBITOR | IC50 | 4.54 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
Egl nine homolog 2 | Enzyme | INHIBITOR | IC50 | 5.24 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
Egl nine homolog 3 | Enzyme | INHIBITOR | IC50 | 5.18 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
Thyroid hormone receptor alpha | Nuclear hormone receptor | EC50 | 7.49 | CHEMBL | |||||
Thyroid hormone receptor beta | Nuclear hormone receptor | EC50 | 7.89 | CHEMBL | |||||
Alpha-ketoglutarate-dependent dioxygenase FTO | Unclassified | IC50 | 5.01 | CHEMBL | |||||
Prolyl 4-hydroxylase | Unclassified | Ki | 5.97 | CHEMBL |
ID | Source |
---|---|
CHEBI:132774 | CHEBI |
CHEMBL2338329 | ChEMBL_ID |
D10593 | KEGG_DRUG |
C584543 | MESH_SUPPLEMENTAL_RECORD_UI |
8454 | IUPHAR_LIGAND_ID |
DB04847 | DRUGBANK_ID |
018888 | NDDF |
C4310578 | UMLSCUI |
8HO | PDB_CHEM_ID |
9717 | INN_ID |
11256664 | PUBCHEM_CID |
X3O30D9YMX | UNII |
None