prabotulinumtoxinA 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	5331	93384-43-1

Description:

Molecule

Description

Synonyms:

prabotulinumtoxinA
prabotulinumtoxinA-xvsf
jeuveau
DWP450

PrabotulinumtoxinA-xvfs is an acetylcholine release inhibitor and a neuromuscular blocking agent

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Feb. 1, 2019	FDA	EVOLUS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	813.58	172.33	326	797	674136	62813763
Drug ineffective	643.87	172.33	316	807	1044449	62443450
Drug effect less than expected	405.63	172.33	61	1062	1628	63486271

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	480.64	155.57	188	392	907027	78836781
Drug effect less than expected	260.71	155.57	38	542	2046	79741762

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Rhytidectomy of glabellar frown lines	indication	14667004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Synaptosomal-associated protein 25	Cytosolic other	P60880	SNP25_HUMAN	BLOCKER				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
0A6JH35GMQ	UNII
C4762545	UMLSCUI
CHEMBL4297229	ChEMBL_ID
DB00083	DRUGBANK_ID
D11405	KEGG_DRUG
C586826	MESH_SUPPLEMENTAL_RECORD_UI
4038426	VANDF
2117872	RXNORM
328337	MMSL
37848	MMSL
d09465	MMSL
C000630868	MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None