cefatrizine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, cefalosporanic acid derivatives | 529 | 51627-14-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Orally active semisynthetic cephalosporin antibiotic with broad-spectrum activity.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 30.89 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 66 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.22 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 3.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.40 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.20 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01DB07 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS First-generation cephalosporins |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| CHEBI has role | CHEBI:36047 | antibacterial drugs |
| CHEBI has role | CHEBI:131734 | elongation factor 2 kinase (EC 2.7.11.20) inhibitor |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.1 | acidic |
| pKa2 | 6.75 | acidic |
| pKa3 | 9.72 | acidic |
| pKa4 | 13.53 | acidic |
| pKa5 | 7.63 | Basic |
| pKa6 | 0.02 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| N0000166880 | NUI |
| D02406 | KEGG_DRUG |
| 2179 | RXNORM |
| C0007545 | UMLSCUI |
| CHEBI:131730 | CHEBI |
| CHEMBL1095284 | ChEMBL_ID |
| D002436 | MESH_DESCRIPTOR_UI |
| DB13266 | DRUGBANK_ID |
| 12204 | IUPHAR_LIGAND_ID |
| 3839 | INN_ID |
| 8P4W949T8K | UNII |
| 6410758 | PUBCHEM_CID |
| 50020121000188105 | SNOMEDCT_US |
| 96056009 | SNOMEDCT_US |
| 004202 | NDDF |
Pharmaceutical products:
None