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morinidazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antiprotozoals and radiosensitizers, metronidazole derivatives | 5255 | 92478-27-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Morinidazole is a nitroimidazole antibiotic indicated for the treatment of sensitive anaerobic bacterial infections including appendicitis and pelvic inflammatory disease caused by anaerobic bacteria.
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 0.75 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 1.60 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 6.20 hours | Lombardo F, Berellini G, Obach RS |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAP3K21,MAP3K7,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PRKDC,SIK2,STK33,TEK | 27 | |||
| kinase-selectivity-class | AXL,BRAF,CAMK2D,CDK9,DDR1,DYRK1B,GRK2,IRAK1,MAP2K6,MAPK7,PRKDC,SIK2,STK33,TEK,TTK | 15 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Feb. 24, 2014 | China Food and Drug Administration (CFDA) | Hansoh |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.12 | acidic |
| pKa2 | 6.52 | Basic |
| pKa3 | 1.93 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| C2932137 | UMLSCUI |
| CHEBI:230801 | CHEBI |
| CHEMBL3884248 | ChEMBL_ID |
| 11644726 | PUBCHEM_CID |
| DB15098 | DRUGBANK_ID |
| C547405 | MESH_SUPPLEMENTAL_RECORD_UI |
| 11830 | INN_ID |
| TUPWG40JAL | UNII |
| TUPWG40JAL | INXIGHT DRUGS |
Pharmaceutical products:
None