pemafibrate indications/contra

Stem definitionDrug idCAS RN
clofibrate derivatives 5248 848259-27-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pemafibrate
  • parmodia
  • K-877
  • (R)-K-13675
Pemafibrate is a selective PPAR-alpha modulator (SPPARM-alpha) that has antihyperlipidaemic activity.
  • Molecular weight: 490.56
  • Formula: C28H30N2O6
  • CLOGP: 6.23
  • LIPINSKI: 1
  • HAC: 8
  • HDO: 1
  • TPSA: 94.26
  • ALOGS: -4.37
  • ROTB: 13

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
July 3, 2017 PMDA Kowa

FDA Adverse Event Reporting System

None

Pharmacologic Action:

None

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Dyslipidemia indication 370992007

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.58 acidic
pKa2 1.94 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Peroxisome proliferator-activated receptor alpha Nuclear hormone receptor AGONIST EC50 9 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Peroxisome proliferator-activated receptor gamma Nuclear hormone receptor AGONIST EC50 5.96 SCIENTIFIC LITERATURE
Peroxisome proliferator-activated receptor delta Nuclear hormone receptor AGONIST EC50 5.80 SCIENTIFIC LITERATURE

External reference:

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IDSource
17VGG92R23 UNII
9692 INN_ID
CHEMBL3545412 ChEMBL_ID
D10711 KEGG_DRUG
C540740 MESH_SUPPLEMENTAL_RECORD_UI
11526038 PUBCHEM_CID

Pharmaceutical products:

None