polmacoxib 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| selective cyclo-oxygenase inhibitors | 5240 | 301692-76-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Polmacoxib is a nonsteroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis. It is a selective COX-2 inhibitor.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Feb. 5, 2015 | Korean Food and Drug Administration (KFDA) | CrystalGenomics |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | M01AH07 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Coxibs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Osteoarthritis | indication | 396275006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.72 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 2 | Enzyme | INHIBITOR | IC50 | 8.08 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Prostaglandin G/H synthase 1 | Enzyme | INHIBITOR | IC50 | 6.08 | SCIENTIFIC LITERATURE | ||||
| Prostaglandin G/H synthase 1 | Enzyme | IC50 | 8.52 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| IJ34D6YPAO | UNII |
| C4519118 | UMLSCUI |
| 949 | PDB_CHEM_ID |
| CHEMBL166863 | ChEMBL_ID |
| 9841854 | PUBCHEM_CID |
| DB12399 | DRUGBANK_ID |
| D10656 | KEGG_DRUG |
| 9898 | INN_ID |
| 8316 | IUPHAR_LIGAND_ID |
| 018797 | NDDF |
| C000599293 | MESH_SUPPLEMENTAL_RECORD_UI |
Pharmaceutical products:
None