midostaurin Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
5231 120685-11-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • midostaurin
  • CGP 41251
  • PKC 412
  • rydapt
Midostaurin is a small molecule that inhibits multiple receptor tyrosine kinases. In vitro biochemical or cellular assays have shown that midostaurin or its major human active metabolites CGP62221 and CGP52421 inhibit the activity of wild type FLT3, FLT3 mutant kinases (ITD and TKD), KIT (wild type and D816V mutant), PDGFR-alfa/beta, VEGFR2, as well as members of the serine/threonine kinase PKC (protein kinase C) family. Midostaurin demonstrated the ability to inhibit FLT3 receptor signaling and cell proliferation, and it induced apoptosis in leukemic cells expressing ITD and TKD mutant FLT3 receptors or overexpressing wild type FLT3 and PDGF receptors. Midostaurin also demonstrated the ability to inhibit KIT signaling, cell proliferation and histamine release and induce apoptosis in mast cells.
  • Molecular weight: 570.65
  • Formula: C35H30N4O4
  • CLOGP: 5.49
  • LIPINSKI: 2
  • HAC: 8
  • HDO: 1
  • TPSA: 77.73
  • ALOGS: -4.56
  • ROTB: 3

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 18, 2017 EMA Novartis Europharm Ltd
April 28, 2017 FDA NOVARTIS PHARMS CORP

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Nausea 177.16 54.30 88 716 177245 4460943
Neutropenic colitis 134.55 54.30 22 782 647 4637541
Death 109.91 54.30 67 737 198096 4440092
Febrile neutropenia 98.81 54.30 34 770 26278 4611910
Sepsis 93.06 54.30 37 767 42802 4595386
Systemic mastocytosis 88.49 54.30 12 792 91 4638097
Diarrhoea 83.41 54.30 51 753 150134 4488054
Cytopenia 83.29 54.30 18 786 2408 4635780
Thrombocytopenia 79.16 54.30 34 770 47639 4590549
Vomiting 75.03 54.30 44 760 119655 4518533
Electrocardiogram QT prolonged 74.17 54.30 24 780 15271 4622917
Neutropenia 69.19 54.30 31 773 47919 4590269
Pneumonia 64.86 54.30 38 766 102777 4535411
Septic shock 56.39 54.30 20 784 16746 4621442

Pharmacologic Action:

SourceCodeDescription
ATC L01XE39 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Protein kinase inhibitors
CHEBI has role CHEBI:35610 antineoplastic agent
FDA EPC N0000175605 Kinase Inhibitor
FDA MoA N0000020000 Receptor Tyrosine Kinase Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Acute myeloid leukemia, disease indication 91861009
Mast cell leukemia indication 110002002
Aggressive systemic mastocytosis indication 716655008 DOID:4798

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.7 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
25MG RYDAPT NOVARTIS N207997 April 28, 2017 RX CAPSULE ORAL 8222244 Oct. 29, 2022 TREATMENT OF ADULT PATIENTS WITH NEWLY DIAGNOSED ACUTE MYELOID LEUKEMIA (AML) WHO ARE FLT3 MUTATION-POSITIVE, IN COMBINATION WITH STANDARD CYTARABINE AND DAUNORUBICIN INDUCTION AND CYTARABINE CONSOLIDATION CHEMOTHERAPY
25MG RYDAPT NOVARTIS N207997 April 28, 2017 RX CAPSULE ORAL 7973031 Oct. 17, 2024 TREATMENT OF ADULT PATIENTS WITH NEWLY DIAGNOSED ACUTE MYELOID LEUKEMIA (AML) WHO ARE FLT3 MUTATION-POSITIVE, IN COMBINATION WITH STANDARD CYTARABINE AND DAUNORUBICIN INDUCTION AND CYTARABINE CONSOLIDATION CHEMOTHERAPY
25MG RYDAPT NOVARTIS N207997 April 28, 2017 RX CAPSULE ORAL 8575146 Dec. 2, 2030 TREATMENT OF ADULT PATIENTS WITH AGGRESSIVE SYSTEMIC MASTOCYTOSIS (ASM), SYSTEMIC MASTOCYTOSIS WITH ASSOCIATED HEMATOLOGICAL NEOPLASM (SM-AHN), OR MAST CELL LEUKEMIA (MCL)

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
25MG RYDAPT NOVARTIS N207997 April 28, 2017 RX CAPSULE ORAL April 28, 2022 NEW CHEMICAL ENTITY
25MG RYDAPT NOVARTIS N207997 April 28, 2017 RX CAPSULE ORAL April 28, 2024 TREATMENT OF ADULT PATIENTS WITH AGGRESSIVE SYSTEMIC MASTOCYTOSIS (ASM), SYSTEMIC MASTOCYTOSIS WITH ASSOCIATED HEMATOLOGICAL NEOPLASM (SM-AHN), OR MAST CELL LEUKEMIA (MCL)
25MG RYDAPT NOVARTIS N207997 April 28, 2017 RX CAPSULE ORAL April 28, 2024 TREATMENT OF ADULT PATIENTS WITH NEWLY DIAGNOSED ACUTE MYELOID LEUKEMIA (AML) THAT IS FLT3 MUTATION-POSITIVE AS DETECTED BY AN FDA APPROVED TEST, IN COMBINATION WITH STANDARD CYTARABINE AND DAUNORUBICIN INDUCTION AND CYTARABINE CONSOLIDATION

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Receptor-type tyrosine-protein kinase FLT3 Kinase INHIBITOR Kd 7.96 IUPHAR DRUG LABEL
Vascular endothelial growth factor receptor 3 Kinase Kd 6.17 CHEMBL
Serine/threonine-protein kinase PAK 3 Kinase Kd 6.75 CHEMBL
3-phosphoinositide-dependent protein kinase 1 Kinase Kd 6.96 CHEMBL
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Kinase Kd 6.72 CHEMBL
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Kinase Kd 6.51 CHEMBL
Ribosomal protein S6 kinase alpha-6 Kinase Kd 5.82 CHEMBL
Myosin light chain kinase family member 4 Kinase Kd 6.19 CHEMBL
Vascular endothelial growth factor receptor 2 Kinase IC50 6.60 CHEMBL
Tyrosine-protein kinase Yes Kinase Kd 6.02 CHEMBL
Serine/threonine-protein kinase 25 Kinase Kd 5.75 CHEMBL
Tyrosine-protein kinase ZAP-70 Kinase Kd 5.59 CHEMBL
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Kinase Kd 6.57 CHEMBL
cAMP-dependent protein kinase catalytic subunit beta Kinase Kd 6.62 CHEMBL
cAMP-dependent protein kinase catalytic subunit PRKX Unclassified Kd 6.02 CHEMBL
Protein-tyrosine kinase 2-beta Kinase Kd 6.18 CHEMBL
Dual specificity protein kinase CLK1 Kinase Kd 6.46 CHEMBL
Tyrosine-protein kinase CSK Kinase Kd 5.06 CHEMBL
Tyrosine-protein kinase receptor Tie-1 Kinase Kd 5.85 CHEMBL
Angiopoietin-1 receptor Kinase Kd 5.72 CHEMBL
TRAF2 and NCK-interacting protein kinase Kinase Kd 5.80 CHEMBL
Activated CDC42 kinase 1 Kinase Kd 6.92 CHEMBL
High affinity nerve growth factor receptor Kinase Kd 6.42 CHEMBL
BDNF/NT-3 growth factors receptor Kinase Kd 6.51 CHEMBL
NT-3 growth factor receptor Kinase Kd 5.77 CHEMBL
Dual specificity protein kinase TTK Kinase Kd 6.46 CHEMBL
Casein kinase II subunit alpha Kinase Kd 6.60 CHEMBL
Death-associated protein kinase 2 Kinase Kd 6.05 CHEMBL
Serine/threonine-protein kinase 17B Kinase Kd 5.33 CHEMBL
Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Kd 6.48 CHEMBL
Glycogen synthase kinase-3 alpha Kinase Kd 5.60 CHEMBL
Glycogen synthase kinase-3 beta Kinase Kd 5.75 CHEMBL
Inhibitor of nuclear factor kappa-B kinase subunit epsilon Kinase Kd 6.80 CHEMBL
Non-receptor tyrosine-protein kinase TYK2 Kinase Kd 6.60 CHEMBL
Mitogen-activated protein kinase 8 Kinase Kd 5.36 CHEMBL
Serine/threonine-protein kinase STK11 Kinase Kd 6.46 CHEMBL
MAP/microtubule affinity-regulating kinase 3 Kinase Kd 7.68 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 3 Kinase Kd 5.28 CHEMBL
Maternal embryonic leucine zipper kinase Kinase Kd 6.55 CHEMBL
AP2-associated protein kinase 1 Kinase Kd 7.32 CHEMBL
Serine/threonine-protein kinase 4 Kinase Kd 7.77 CHEMBL
Eukaryotic translation initiation factor 2-alpha kinase 4 Kinase Kd 7.41 CHEMBL
Tyrosine-protein kinase HCK Kinase Kd 6.14 CHEMBL
Tyrosine-protein kinase ABL1 Kinase Kd 6.10 CHEMBL
Interleukin-1 receptor-associated kinase 3 Kinase Kd 6.75 CHEMBL
Tyrosine-protein kinase JAK2 Kinase Kd 7.03 CHEMBL
Tyrosine-protein kinase JAK3 Kinase Kd 7.92 CHEMBL
Mitogen-activated protein kinase 10 Kinase Kd 5.44 CHEMBL
Mast/stem cell growth factor receptor Kit Kinase Kd 8.11 CHEMBL
Serine/threonine-protein kinase RIO1 Kinase Kd 5.92 CHEMBL
Serine/threonine-protein kinase RIO3 Kinase Kd 6.38 CHEMBL
Serine/threonine-protein kinase SIK2 Kinase Kd 6.25 CHEMBL
SRSF protein kinase 1 Kinase Kd 7.38 CHEMBL
SRSF protein kinase 2 Kinase Kd 6.48 CHEMBL
Non-receptor tyrosine-protein kinase TNK1 Kinase Kd 7.08 CHEMBL
Testis-specific serine/threonine-protein kinase 1 Kinase Kd 5.32 CHEMBL
Tyrosine-protein kinase Fyn Kinase Kd 5.68 CHEMBL
Cyclin-G-associated kinase Kinase Kd 6.42 CHEMBL
ALK tyrosine kinase receptor Kinase Kd 6.57 CHEMBL
5'-AMP-activated protein kinase catalytic subunit alpha-1 Kinase Kd 6.75 CHEMBL
5'-AMP-activated protein kinase catalytic subunit alpha-2 Kinase Kd 6.34 CHEMBL
Epithelial discoidin domain-containing receptor 1 Kinase Kd 5.14 CHEMBL
Myotonin-protein kinase Kinase Kd 5.42 CHEMBL
RAC-alpha serine/threonine-protein kinase Kinase Kd 6.02 CHEMBL
RAC-beta serine/threonine-protein kinase Kinase Kd 6.11 CHEMBL
Serine/threonine-protein kinase LATS1 Kinase Kd 5.96 CHEMBL
Serine/threonine-protein kinase LATS2 Kinase Kd 5.66 CHEMBL
Tyrosine-protein kinase Lck Kinase Kd 6.55 CHEMBL
Serine/threonine-protein kinase 10 Kinase Kd 6.23 CHEMBL
Leukocyte tyrosine kinase receptor Kinase Kd 5.52 CHEMBL
Tyrosine-protein kinase Lyn Kinase Kd 5.38 CHEMBL
Serine/threonine-protein kinase 17A Kinase Kd 5.72 CHEMBL
Epidermal growth factor receptor Kinase Kd 8.06 CHEMBL
NUAK family SNF1-like kinase 1 Kinase Kd 7.39 CHEMBL
Aurora kinase A Kinase IC50 7.10 CHEMBL
Platelet-derived growth factor receptor alpha Kinase Kd 6.75 CHEMBL
Platelet-derived growth factor receptor beta Kinase Kd 6.96 CHEMBL
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Kinase Kd 6.05 CHEMBL
Serine/threonine-protein kinase pim-1 Kinase Kd 6.25 CHEMBL
Serine/threonine-protein kinase pim-3 Kinase Kd 6.25 CHEMBL
cAMP-dependent protein kinase catalytic subunit alpha Kinase Kd 6.14 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 1 Kinase Kd 5.68 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 3 Kinase Kd 6.92 CHEMBL
Aurora kinase B Kinase Kd 7.21 CHEMBL
Tyrosine-protein kinase receptor UFO Kinase Kd 6.21 CHEMBL
BMP-2-inducible protein kinase Kinase Kd 6.66 CHEMBL
Tyrosine-protein kinase Blk Kinase Kd 6.30 CHEMBL
Serine/threonine-protein kinase BRSK1 Kinase Kd 5.92 CHEMBL
Calcium/calmodulin-dependent protein kinase type 1D Kinase Kd 6.17 CHEMBL
Calcium/calmodulin-dependent protein kinase type 1G Kinase Kd 5.75 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 4 Kinase Kd 6.19 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 5 Kinase Kd 5.96 CHEMBL
Serine/threonine-protein kinase MARK1 Kinase Kd 6.77 CHEMBL
Serine/threonine-protein kinase MARK2 Kinase Kd 7 CHEMBL
MAP/microtubule affinity-regulating kinase 4 Kinase Kd 6.43 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 4 Kinase Kd 5.32 CHEMBL
Tyrosine-protein kinase Mer Kinase Kd 5.54 CHEMBL
Hepatocyte growth factor receptor Kinase Kd 6.25 CHEMBL
Calcium/calmodulin-dependent protein kinase type II subunit alpha Kinase Kd 7.70 CHEMBL
Calcium/calmodulin-dependent protein kinase type II subunit beta Kinase Kd 6.68 CHEMBL
Calcium/calmodulin-dependent protein kinase type II subunit delta Kinase Kd 7.44 CHEMBL
Calcium/calmodulin-dependent protein kinase type II subunit gamma Kinase Kd 6.85 CHEMBL
Calcium/calmodulin-dependent protein kinase kinase 1 Kinase Kd 6.89 CHEMBL
Calcium/calmodulin-dependent protein kinase kinase 2 Kinase Kd 7.14 CHEMBL
Cyclin-dependent kinase 19 Kinase Kd 5.14 CHEMBL
MAP kinase-interacting serine/threonine-protein kinase 2 Kinase Kd 6.02 CHEMBL
Mitogen-activated protein kinase kinase kinase 9 Kinase Kd 7.82 CHEMBL
Mitogen-activated protein kinase kinase kinase 10 Kinase Kd 6.10 CHEMBL
Mitogen-activated protein kinase kinase kinase 11 Kinase Kd 7.77 CHEMBL
Serine/threonine-protein kinase 3 Kinase Kd 7.40 CHEMBL
Myosin light chain kinase, smooth muscle Kinase Kd 6.66 CHEMBL
Serine/threonine-protein kinase Chk1 Kinase Kd 5.89 CHEMBL
Dual specificity protein kinase CLK2 Kinase Kd 6.07 CHEMBL
Dual specificity protein kinase CLK4 Kinase Kd 6.39 CHEMBL
Macrophage colony-stimulating factor 1 receptor Kinase IC50 6.85 CHEMBL
Death-associated protein kinase 1 Kinase Kd 5.33 CHEMBL
Death-associated protein kinase 3 Kinase Kd 5.75 CHEMBL
Serine/threonine-protein kinase PAK 1 Kinase Kd 5.70 CHEMBL
Serine/threonine-protein kinase PAK 2 Kinase Kd 5.68 CHEMBL
Tyrosine-protein kinase FRK Kinase Kd 5.62 CHEMBL
Aurora kinase C Kinase Kd 6.77 CHEMBL
Serine/threonine-protein kinase BRSK2 Kinase Kd 6.19 CHEMBL
Calcium/calmodulin-dependent protein kinase type 1 Kinase Kd 5.70 CHEMBL
STE20-like serine/threonine-protein kinase Kinase Kd 6.66 CHEMBL
NUAK family SNF1-like kinase 2 Kinase Kd 7.20 CHEMBL
Serine/threonine-protein kinase SIK1 Kinase Kd 6.80 CHEMBL
Proto-oncogene tyrosine-protein kinase Src Kinase Kd 5.92 CHEMBL
Serine/threonine-protein kinase 16 Kinase Kd 6.55 CHEMBL
Tyrosine-protein kinase SYK Kinase Kd 7.06 CHEMBL
Serine/threonine-protein kinase N1 Kinase Kd 8.03 CHEMBL
Serine/threonine-protein kinase N2 Kinase Kd 7.82 CHEMBL
Serine/threonine-protein kinase PLK4 Kinase Kd 7.18 CHEMBL
Protein kinase C delta type Kinase Kd 6.50 CHEMBL
Protein kinase C epsilon type Kinase Kd 6.27 CHEMBL
Protein kinase C eta type Kinase Kd 6.54 CHEMBL
Protein kinase C theta type Kinase Kd 6.04 CHEMBL
Tyrosine-protein kinase Fer Kinase Kd 5.92 CHEMBL
Serine/threonine-protein kinase D2 Kinase Kd 5.20 CHEMBL
Serine/threonine-protein kinase D3 Kinase Kd 5.50 CHEMBL
cGMP-dependent protein kinase 1 Kinase Kd 6.60 CHEMBL
cGMP-dependent protein kinase 2 Kinase Kd 7.13 CHEMBL
Interferon-induced, double-stranded RNA-activated protein kinase Kinase Kd 5.16 CHEMBL
Proto-oncogene tyrosine-protein kinase receptor Ret Kinase Kd 7.70 CHEMBL
Fibroblast growth factor receptor 1 Kinase Kd 5.80 CHEMBL
Fibroblast growth factor receptor 2 Kinase Kd 5.62 CHEMBL
Fibroblast growth factor receptor 3 Kinase Kd 5.77 CHEMBL
Tyrosine-protein kinase Fgr Kinase Kd 6.14 CHEMBL
Vascular endothelial growth factor receptor 1 Kinase Kd 6.35 CHEMBL
Proto-oncogene tyrosine-protein kinase ROS Kinase Kd 6.37 CHEMBL
Ribosomal protein S6 kinase alpha-1 Kinase Kd 6.59 CHEMBL
Ribosomal protein S6 kinase alpha-2 Kinase Kd 6.62 CHEMBL
Homeodomain-interacting protein kinase 2 Kinase Kd 5.51 CHEMBL
Ribosomal protein S6 kinase alpha-3 Kinase Kd 6.13 CHEMBL
Ribosomal protein S6 kinase alpha-4 Kinase Kd 6.59 CHEMBL
Ribosomal protein S6 kinase alpha-5 Kinase Kd 6.62 CHEMBL
Dual specificity tyrosine-phosphorylation-regulated kinase 1A Kinase Kd 7 CHEMBL
Ephrin type-B receptor 6 Kinase Kd 5.51 CHEMBL
Receptor tyrosine-protein kinase erbB-4 Kinase Kd 5.51 CHEMBL
Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase Kd 5.64 CHEMBL
Rhodopsin kinase Kinase Kd 7.07 CHEMBL
G protein-coupled receptor kinase 4 Kinase Kd 6.96 CHEMBL
G protein-coupled receptor kinase 7 Kinase Kd 7.32 CHEMBL
Homeodomain-interacting protein kinase 3 Kinase Kd 5.64 CHEMBL
Homeodomain-interacting protein kinase 4 Kinase Kd 6.02 CHEMBL
Hormonally up-regulated neu tumor-associated kinase Kinase Kd 6.62 CHEMBL
Inhibitor of nuclear factor kappa-B kinase subunit alpha Kinase Kd 5.42 CHEMBL
Tyrosine-protein kinase JAK1 Kinase Kd 6.17 CHEMBL
Mitogen-activated protein kinase kinase kinase 13 Kinase Kd 5.55 CHEMBL
Mitogen-activated protein kinase kinase kinase 2 Kinase Kd 6.85 CHEMBL
Mitogen-activated protein kinase kinase kinase 3 Kinase Kd 6.68 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 2 Kinase Kd 5.60 CHEMBL
Misshapen-like kinase 1 Kinase Kd 6.77 CHEMBL
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta Kinase Kd 5.85 CHEMBL
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma Kinase Kd 6.24 CHEMBL
Protein kinase C alpha type Kinase Kd 6.14 CHEMBL
U4/U6 small nuclear ribonucleoprotein Prp4 Unclassified Kd 7.26 CHEMBL
Serine/threonine-protein kinase SIK3 Kinase Kd 7.01 CHEMBL
Serine/threonine-protein kinase RIO2 Kinase Kd 7.01 CHEMBL
Rho-associated protein kinase 1 Kinase Kd 5.11 CHEMBL
Rho-associated protein kinase 2 Kinase Kd 5.64 CHEMBL
SRSF protein kinase 3 Kinase Kd 7.10 CHEMBL
Mitogen-activated protein kinase kinase kinase 7 Kinase Kd 6.89 CHEMBL
Serine/threonine-protein kinase TBK1 Kinase Kd 8.03 CHEMBL
Tankyrase-2 Enzyme Kd 6.92 CHEMBL
Serine/threonine-protein kinase ULK3 Kinase Kd 5.89 CHEMBL
Mitogen-activated protein kinase kinase kinase 19 Kinase Kd 7.82 CHEMBL
Serine/threonine-protein kinase 32A Kinase Kd 5.62 CHEMBL
Inhibitor of nuclear factor kappa-B kinase subunit beta Kinase Kd 5.20 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 6 Kinase Kd 5.19 CHEMBL
Ribosomal protein S6 kinase beta-1 Kinase Kd 5.89 CHEMBL
Wee1-like protein kinase Kinase Kd 5.34 CHEMBL
Serine/threonine-protein kinase PRP4 homolog Kinase Kd 7.26 CHEMBL
Dual specificity protein kinase CLK3 Kinase Kd 5.44 CHEMBL
RAC-gamma serine/threonine-protein kinase Kinase Kd 5.36 CHEMBL
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Kinase Kd 5.96 CHEMBL
Serine/threonine-protein kinase pim-2 Kinase Kd 5.51 CHEMBL
Serine/threonine-protein kinase Sgk3 Kinase Kd 5.85 CHEMBL
Serine/threonine-protein kinase ICK Kinase Kd 5.23 CHEMBL
Microtubule-associated serine/threonine-protein kinase 1 Kinase Kd 6.72 CHEMBL
Serine/threonine-protein kinase 33 Kinase Kd 6.72 CHEMBL
Mitogen-activated protein kinase 9 Kinase Kd 5.30 CHEMBL
Myosin light chain kinase 3 Kinase Kd 5.64 CHEMBL
Leucine-rich repeat serine/threonine-protein kinase 2 Kinase Kd 6.75 CHEMBL
Dual serine/threonine and tyrosine protein kinase Kinase Kd 5.33 CHEMBL
Tubulin alpha-1A chain Structural Kd 5.51 CHEMBL
Calcium-dependent protein kinase 1 Kinase Kd 6.02 CHEMBL

External reference:

IDSource
763613005 SNOMEDCT_US
763614004 SNOMEDCT_US
1919083 RXNORM
32671 MMSL
d08575 MMSL
017198 NDDF
4036652 VANDF
9829523 PUBCHEM_CID
CHEBI:63452 CHEBI
CHEMBL608533 ChEMBL_ID
D05029 KEGG_DRUG
ID912S5VON UNII
7677 INN_ID
DB06595 DRUGBANK_ID
5702 IUPHAR_LIGAND_ID
C059539 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
RYDAPT HUMAN PRESCRIPTION DRUG LABEL 1 0078-0698 CAPSULE, LIQUID FILLED 25 mg ORAL NDA 16 sections