niraparib 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
poly-ADP-ribose polymerase inhibitors 5222 1038915-60-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • niraparib hydrochloride
  • niraparib HCl
  • MK-4827
  • niraparib
  • niraparib tosylate monohydrate
  • niraparib tosylate
  • zejula
Niraparib is an inhibitor of poly(ADP-ribose) polymerase (PARP) enzymes, PARP-1 and PARP-2, which play a role in DNA repair. In vitro studies have shown that niraparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complexes resulting in DNA damage, apoptosis and cell death. Increased niraparib-induced cytotoxicity was observed in tumor cell lines with or without deficiencies in BRCA1/2. Niraparib decreased tumor growth in mouse xenograft models of human cancer cell lines with deficiencies in BRCA1/2 and in human patient-derived xenograft tumor models with homologous recombination deficiency that had either mutated or wild type BRCA1/2.
  • Molecular weight: 320.40
  • Formula: C19H20N4O
  • CLOGP: 2.79
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 72.94
  • ALOGS: -4.33
  • ROTB: 3

  • Status: ONP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 0.70 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Nov. 16, 2017 EMA Tesaro UK Limited
March 27, 2017 FDA TESARO INC
Sept. 25, 2020 PMDA TAKEDA PHARMACEUTICAL COMPANY LIMITED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Platelet count decreased 990.46 26.91 478 12460 115644 63360440
Carbohydrate antigen 125 increased 647.47 26.91 143 12795 2673 63473411
Recurrent cancer 581.09 26.91 123 12815 1864 63474220
Disease progression 493.40 26.91 308 12630 122450 63353634
Malignant neoplasm progression 401.82 26.91 234 12704 81887 63394197
Constipation 358.48 26.91 324 12614 224619 63251465
Thrombocytopenia 346.96 26.91 269 12669 150888 63325196
Intentional underdose 243.68 26.91 60 12878 1822 63474262
Nausea 224.40 26.91 517 12421 853954 62622130
Insomnia 186.37 26.91 224 12714 215028 63261056
Blood pressure increased 178.20 26.91 191 12747 161871 63314213
Haemoglobin decreased 164.38 26.91 174 12764 145311 63330773
Red blood cell count decreased 162.72 26.91 102 12836 40543 63435541
Renal impairment 153.49 26.91 134 12804 88221 63387863
Heart rate increased 121.33 26.91 121 12817 94117 63381967
Fatigue 121.17 26.91 425 12513 887603 62588481
Ovarian cancer recurrent 119.49 26.91 30 12908 987 63475097
Myelodysplastic syndrome 118.40 26.91 61 12877 16693 63459391
Decreased activity 116.28 26.91 45 12893 6275 63469809
Anaemia 113.21 26.91 209 12729 293221 63182863
Tumour marker increased 97.60 26.91 37 12901 4878 63471206
Neutrophil count decreased 88.84 26.91 81 12857 56325 63419759
White blood cell count decreased 83.28 26.91 121 12817 138983 63337101
Product dose omission issue 80.50 26.91 159 12779 234154 63241930
Full blood count abnormal 80.27 26.91 60 12878 31657 63444427
Product dose omission in error 75.67 26.91 35 12903 7577 63468507
Dry mouth 75.41 26.91 86 12852 77777 63398307
Ovarian cancer 70.60 26.91 31 12907 5945 63470139
Acute myeloid leukaemia 65.99 26.91 42 12896 17105 63458979
Decreased appetite 63.98 26.91 151 12787 250901 63225183
Blood creatinine increased 59.33 26.91 81 12857 87763 63388321
Intestinal obstruction 49.85 26.91 45 12893 30854 63445230
Haematocrit decreased 49.61 26.91 50 12888 39290 63436794
Neuropathy peripheral 47.52 26.91 84 12854 113583 63362501
Drug monitoring procedure not performed 47.41 26.91 13 12925 605 63475479
Full blood count decreased 46.17 26.91 40 12898 25984 63450100
Platelet count abnormal 41.52 26.91 18 12920 3346 63472738
Drug hypersensitivity 41.02 26.91 7 12931 310680 63165404
Emotional distress 40.36 26.91 41 12897 32508 63443576
Swelling 36.80 26.91 6 12932 275372 63200712
Photosensitivity reaction 34.91 26.91 27 12911 14967 63461117
Metastases to peritoneum 34.75 26.91 16 12922 3426 63472658
Lymphangioleiomyomatosis 34.61 26.91 8 12930 184 63475900
Computerised tomogram abnormal 34.53 26.91 14 12924 2203 63473881
Arthropathy 33.99 26.91 4 12934 234788 63241296
Hypertension 33.67 26.91 129 12809 279174 63196910
Adverse drug reaction 33.41 26.91 59 12879 79655 63396429
Blood test abnormal 31.80 26.91 26 12912 15603 63460481
Joint swelling 31.01 26.91 14 12924 327652 63148432
Eastern Cooperative Oncology Group performance status worsened 30.65 26.91 11 12927 1243 63474841
Treatment failure 29.80 26.91 3 12935 199040 63277044
Blood magnesium decreased 29.07 26.91 23 12915 13175 63462909
Ileus 28.92 26.91 24 12914 14701 63461383
Myelosuppression 27.83 26.91 29 12909 23674 63452410
Headache 27.82 26.91 222 12716 633019 62843065
Hypersensitivity 26.92 26.91 13 12925 292672 63183412

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Platelet count decreased 592.58 25.44 336 9107 194328 79540617
Recurrent cancer 516.21 25.44 107 9336 2586 79732359
Carbohydrate antigen 125 increased 484.63 25.44 98 9345 2086 79732859
Disease progression 384.15 25.44 250 9193 184112 79550833
Thrombocytopenia 257.42 25.44 228 9215 265031 79469914
Constipation 227.42 25.44 219 9224 282831 79452114
Intentional underdose 204.70 25.44 49 9394 2305 79732640
Nausea 177.42 25.44 364 9079 956832 78778113
Blood pressure increased 113.13 25.44 132 9311 211228 79523717
Insomnia 106.79 25.44 138 9305 245032 79489913
Ovarian cancer recurrent 98.90 25.44 20 9423 424 79734521
Anaemia 97.17 25.44 182 9261 444833 79290112
Renal impairment 93.61 25.44 104 9339 157679 79577266
Myelodysplastic syndrome 93.43 25.44 53 9390 30248 79704697
Haemoglobin decreased 91.98 25.44 122 9321 221997 79512948
Malignant neoplasm progression 90.05 25.44 95 9348 135895 79599050
Red blood cell count decreased 88.63 25.44 65 9378 57448 79677497
Ovarian cancer 87.20 25.44 28 9415 3906 79731039
Fatigue 83.69 25.44 270 9173 929457 78805488
Decreased activity 79.05 25.44 32 9411 8662 79726283
Neutrophil count decreased 71.91 25.44 71 9372 93888 79641057
Product dose omission in error 65.13 25.44 27 9416 7761 79727184
Acute myeloid leukaemia 64.26 25.44 42 9401 30843 79704102
White blood cell count decreased 58.13 25.44 90 9353 188198 79546747
Heart rate increased 55.66 25.44 70 9373 120654 79614291
Decreased appetite 53.29 25.44 122 9321 342296 79392649
Product dose omission issue 52.30 25.44 100 9343 247437 79487508
Tumour marker increased 50.42 25.44 19 9424 4253 79730692
Full blood count abnormal 49.73 25.44 40 9403 40434 79694511
Blood creatinine increased 43.53 25.44 71 9372 154986 79579959
Dry mouth 38.91 25.44 50 9393 87969 79646976
Intestinal obstruction 35.68 25.44 34 9409 42986 79691959
Neuropathy peripheral 34.74 25.44 61 9382 141244 79593701
Headache 33.94 25.44 160 9283 653612 79081333
Vomiting 33.15 25.44 161 9282 665667 79069278
Metastases to peritoneum 32.69 25.44 14 9429 4358 79730587
Full blood count decreased 31.87 25.44 26 9417 26793 79708152
Hypertension 28.47 25.44 95 9348 330897 79404048
Emotional distress 28.33 25.44 29 9414 39940 79695005
Lymphangioleiomyomatosis 28.10 25.44 6 9437 167 79734778
Haematocrit decreased 27.35 25.44 35 9408 61277 79673668
Computerised tomogram abnormal 25.75 25.44 11 9432 3402 79731543
Drug monitoring procedure not performed 25.74 25.44 8 9435 1003 79733942

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01XK02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Poly (ADP-ribose) polymerase (PARP) inhibitors
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D000067856 Poly(ADP-ribose) Polymerase Inhibitors
FDA MoA N0000191622 Poly(ADP-Ribose) Polymerase Inhibitors
FDA EPC N0000191623 Poly(ADP-Ribose) Polymerase Inhibitor
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:62913 PARP
CHEBI has role CHEBI:68495 Type I cell-death inducers
CHEBI has role CHEBI:132992 radiosensitizing agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Carcinoma in situ of fallopian tube indication 92591008
Malignant epithelial tumor of ovary indication 254849005
Malignant tumor of ovary indication 363443007 DOID:2394
Malignant tumor of peritoneum indication 363492001
Hormone refractory prostate cancer indication 427492003




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.95 acidic
pKa2 9.77 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 100MG BASE ZEJULA GLAXOSMITHKLINE N208447 March 27, 2017 RX CAPSULE ORAL 8071579 Aug. 12, 2027 A METHOD OF TREATMENT OF ADVANCED OVARIAN, FALLOPIAN TUBE, OR PRIMARY PERITONEAL CANCER ASSOCIATED WITH HOMOLOGOUS RECOMBINATION DEFICIENCY (HRD) POSITIVE STATUS
EQ 100MG BASE ZEJULA GLAXOSMITHKLINE N208447 March 27, 2017 RX CAPSULE ORAL 8143241 Aug. 12, 2027 A METHOD OF TREATMENT OF ADVANCED OVARIAN, FALLOPIAN TUBE, OR PRIMARY PERITONEAL CANCER ASSOCIATED WITH HOMOLOGOUS RECOMBINATION DEFICIENCY (HRD) POSITIVE STATUS
EQ 100MG BASE ZEJULA GLAXOSMITHKLINE N214876 April 26, 2023 RX TABLET ORAL 8071579 Aug. 12, 2027 A METHOD OF TREATMENT OF ADVANCED OVARIAN, FALLOPIAN TUBE, OR PRIMARY PERITONEAL CANCER ASSOCIATED WITH HOMOLOGOUS RECOMBINATION DEFICIENCY (HRD) POSITIVE STATUS
EQ 100MG BASE ZEJULA GLAXOSMITHKLINE N214876 April 26, 2023 RX TABLET ORAL 8143241 Aug. 12, 2027 A METHOD OF TREATMENT OF ADVANCED OVARIAN, FALLOPIAN TUBE, OR PRIMARY PERITONEAL CANCER ASSOCIATED WITH HOMOLOGOUS RECOMBINATION DEFICIENCY (HRD) POSITIVE STATUS
EQ 200MG BASE ZEJULA GLAXOSMITHKLINE N214876 April 26, 2023 RX TABLET ORAL 8071579 Aug. 12, 2027 A METHOD OF TREATMENT OF ADVANCED OVARIAN, FALLOPIAN TUBE, OR PRIMARY PERITONEAL CANCER ASSOCIATED WITH HOMOLOGOUS RECOMBINATION DEFICIENCY (HRD) POSITIVE STATUS
EQ 200MG BASE ZEJULA GLAXOSMITHKLINE N214876 April 26, 2023 RX TABLET ORAL 8143241 Aug. 12, 2027 A METHOD OF TREATMENT OF ADVANCED OVARIAN, FALLOPIAN TUBE, OR PRIMARY PERITONEAL CANCER ASSOCIATED WITH HOMOLOGOUS RECOMBINATION DEFICIENCY (HRD) POSITIVE STATUS
EQ 300MG BASE ZEJULA GLAXOSMITHKLINE N214876 April 26, 2023 RX TABLET ORAL 8071579 Aug. 12, 2027 A METHOD OF TREATMENT OF ADVANCED OVARIAN, FALLOPIAN TUBE, OR PRIMARY PERITONEAL CANCER ASSOCIATED WITH HOMOLOGOUS RECOMBINATION DEFICIENCY (HRD) POSITIVE STATUS
EQ 300MG BASE ZEJULA GLAXOSMITHKLINE N214876 April 26, 2023 RX TABLET ORAL 8143241 Aug. 12, 2027 A METHOD OF TREATMENT OF ADVANCED OVARIAN, FALLOPIAN TUBE, OR PRIMARY PERITONEAL CANCER ASSOCIATED WITH HOMOLOGOUS RECOMBINATION DEFICIENCY (HRD) POSITIVE STATUS
EQ 100MG BASE ZEJULA GLAXOSMITHKLINE N208447 March 27, 2017 RX CAPSULE ORAL 8859562 Aug. 4, 2031 A METHOD OF TREATMENT OF ADVANCED OVARIAN, FALLOPIAN TUBE, OR PRIMARY PERITONEAL CANCER ASSOCIATED WITH HOMOLOGOUS RECOMBINATION DEFICIENCY (HRD) POSITIVE STATUS
EQ 100MG BASE ZEJULA GLAXOSMITHKLINE N214876 April 26, 2023 RX TABLET ORAL 8859562 Aug. 4, 2031 A METHOD OF TREATMENT OF ADVANCED OVARIAN, FALLOPIAN TUBE, OR PRIMARY PERITONEAL CANCER ASSOCIATED WITH HOMOLOGOUS RECOMBINATION DEFICIENCY (HRD) POSITIVE STATUS
EQ 200MG BASE ZEJULA GLAXOSMITHKLINE N214876 April 26, 2023 RX TABLET ORAL 8859562 Aug. 4, 2031 A METHOD OF TREATMENT OF ADVANCED OVARIAN, FALLOPIAN TUBE, OR PRIMARY PERITONEAL CANCER ASSOCIATED WITH HOMOLOGOUS RECOMBINATION DEFICIENCY (HRD) POSITIVE STATUS
EQ 300MG BASE ZEJULA GLAXOSMITHKLINE N214876 April 26, 2023 RX TABLET ORAL 8859562 Aug. 4, 2031 A METHOD OF TREATMENT OF ADVANCED OVARIAN, FALLOPIAN TUBE, OR PRIMARY PERITONEAL CANCER ASSOCIATED WITH HOMOLOGOUS RECOMBINATION DEFICIENCY (HRD) POSITIVE STATUS
EQ 100MG BASE ZEJULA GLAXOSMITHKLINE N208447 March 27, 2017 RX CAPSULE ORAL 11673877 March 27, 2038 A METHOD OF TREATMENT OF OVARIAN CANCER OR FALLOPIAN TUBE CANCER
EQ 100MG BASE ZEJULA GLAXOSMITHKLINE N208447 March 27, 2017 RX CAPSULE ORAL 11673877 March 27, 2038 A METHOD OF TREATMENT OF RECURRENT OVARIAN CANCER OR FALLOPIAN TUBE CANCER ASSOCIATED WITH DELETERIOUS OR SUSPECTED DELETERIOUS GERMLINE BRCA-MUTATION
EQ 100MG BASE ZEJULA GLAXOSMITHKLINE N214876 April 26, 2023 RX TABLET ORAL 11673877 March 27, 2038 A METHOD OF TREATMENT OF OVARIAN CANCER OR FALLOPIAN TUBE CANCER
EQ 100MG BASE ZEJULA GLAXOSMITHKLINE N214876 April 26, 2023 RX TABLET ORAL 11673877 March 27, 2038 A METHOD OF TREATMENT OF RECURRENT OVARIAN CANCER OR FALLOPIAN TUBE CANCER ASSOCIATED WITH DELETERIOUS OR SUSPECTED DELETERIOUS GERMLINE BRCA-MUTATION
EQ 200MG BASE ZEJULA GLAXOSMITHKLINE N214876 April 26, 2023 RX TABLET ORAL 11673877 March 27, 2038 A METHOD OF TREATMENT OF OVARIAN CANCER OR FALLOPIAN TUBE CANCER
EQ 200MG BASE ZEJULA GLAXOSMITHKLINE N214876 April 26, 2023 RX TABLET ORAL 11673877 March 27, 2038 A METHOD OF TREATMENT OF RECURRENT OVARIAN CANCER OR FALLOPIAN TUBE CANCER ASSOCIATED WITH DELETERIOUS OR SUSPECTED DELETERIOUS GERMLINE BRCA-MUTATION
EQ 300MG BASE ZEJULA GLAXOSMITHKLINE N214876 April 26, 2023 RX TABLET ORAL 11673877 March 27, 2038 A METHOD OF TREATMENT OF OVARIAN CANCER OR FALLOPIAN TUBE CANCER
EQ 300MG BASE ZEJULA GLAXOSMITHKLINE N214876 April 26, 2023 RX TABLET ORAL 11673877 March 27, 2038 A METHOD OF TREATMENT OF RECURRENT OVARIAN CANCER OR FALLOPIAN TUBE CANCER ASSOCIATED WITH DELETERIOUS OR SUSPECTED DELETERIOUS GERMLINE BRCA-MUTATION

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 100MG BASE ZEJULA GLAXOSMITHKLINE N208447 March 27, 2017 RX CAPSULE ORAL April 29, 2023 MAINTENANCE TREATMENT OF ADULT PATIENTS WITH ADVANCED EPITHELIAL OVARIAN, FALLOPIAN TUBE, OR PRIMARY PERITONEAL CANCER WHO ARE IN A COMPLETE OR PARTIAL RESPONSE TO FIRST-LINE PLATINUM-BASED CHEMOTHERAPY
EQ 100MG BASE ZEJULA GLAXOSMITHKLINE N208447 March 27, 2017 RX CAPSULE ORAL March 27, 2024 INDICATED FOR MAINTENANCE TREATMENT OF ADULT PATIENTS WITH RECURRENT EPITHELIAL OVARIAN, FALLOPIAN TUBE, OR PRIMARY PERITONEAL CANCER WHO ARE IN A COMPLETE OR PARTIAL RESPONSE TO PLATINUM-BASED CHEMOTHERAPY
EQ 100MG BASE ZEJULA GLAXOSMITHKLINE N208447 March 27, 2017 RX CAPSULE ORAL Oct. 23, 2026 TX OF ADULTS W/ ADV OVARIAN, FALLOPIAN TUBE, OR PRIMARY PERITONEAL CANCER TREATED W/ >=3 PRIOR CHEMO REGIMENS & CANCER ASSOCIATED W/ HRD+ STATUS DEFINED BY A DELETERIOUS OR SUSPECTED DELETERIOUS BRCA MUTATION
EQ 100MG BASE ZEJULA GLAXOSMITHKLINE N208447 March 27, 2017 RX CAPSULE ORAL April 29, 2027 INDICATED FOR THE MAINTENANCE TREATMENT OF ADULT PATIENTS WITH ADVANCED EPITHELIAL OVARIAN CANCER WHO ARE IN A COMPLETE OR PARTIAL RESPONSE TO FIRST-LINE PLATINUM-BASED CHEMOTHERAPY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Poly [ADP-ribose] polymerase 2 Enzyme INHIBITOR IC50 8.68 IUPHAR DRUG LABEL
Poly [ADP-ribose] polymerase 1 Enzyme INHIBITOR IC50 8.42 IUPHAR DRUG LABEL
Poly [ADP-ribose] polymerase 3 Enzyme IC50 5.89 CHEMBL
Poly [ADP-ribose] polymerase 4 Enzyme IC50 6.48 CHEMBL
Poly [ADP-ribose] polymerase 10 Enzyme IC50 5.72 CHEMBL
Tankyrase-2 Enzyme IC50 5.29 CHEMBL
Poly [ADP-ribose] polymerase 14 Enzyme IC50 5.76 CHEMBL
Poly [ADP-ribose] polymerase 15 Enzyme IC50 4.54 CHEMBL
Poly [ADP-ribose] polymerase 12 Enzyme IC50 7.10 CHEMBL
Tankyrase-1 Enzyme IC50 6.24 CHEMBL

External reference:

IDSource
HMC2H89N35 UNII
1038915-64-8 SECONDARY_CAS_RN
1613220-15-7 SECONDARY_CAS_RN
4036640 VANDF
C2744440 UMLSCUI
CHEBI:176844 CHEBI
3JD PDB_CHEM_ID
CHEMBL1094636 ChEMBL_ID
24958200 PUBCHEM_CID
DB11793 DRUGBANK_ID
D10140 KEGG_DRUG
CHEMBL3989922 ChEMBL_ID
9526 INN_ID
8275 IUPHAR_LIGAND_ID
254987 MMSL
32539 MMSL
d08539 MMSL
017145 NDDF
017146 NDDF
1193870006 SNOMEDCT_US
391000220105 SNOMEDCT_US
733733005 SNOMEDCT_US
763561009 SNOMEDCT_US
1918231 RXNORM
C545685 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ZEJULA HUMAN PRESCRIPTION DRUG LABEL 1 0173-0909 TABLET, FILM COATED 100 mg ORAL NDA 27 sections
ZEJULA HUMAN PRESCRIPTION DRUG LABEL 1 0173-0912 TABLET, FILM COATED 200 mg ORAL NDA 27 sections
ZEJULA HUMAN PRESCRIPTION DRUG LABEL 1 0173-0915 TABLET, FILM COATED 300 mg ORAL NDA 27 sections
AKEEGA HUMAN PRESCRIPTION DRUG LABEL 2 57894-050 TABLET, FILM COATED 50 mg ORAL NDA 32 sections
AKEEGA HUMAN PRESCRIPTION DRUG LABEL 2 57894-100 TABLET, FILM COATED 100 mg ORAL NDA 32 sections
ZEJULA HUMAN PRESCRIPTION DRUG LABEL 1 69656-103 CAPSULE 100 mg ORAL NDA 30 sections
ZEJULA HUMAN PRESCRIPTION DRUG LABEL 1 69656-103 CAPSULE 100 mg ORAL NDA 30 sections
ZEJULA HUMAN PRESCRIPTION DRUG LABEL 1 69656-103 CAPSULE 100 mg ORAL NDA 30 sections
ZEJULA HUMAN PRESCRIPTION DRUG LABEL 1 69656-103 CAPSULE 100 mg ORAL NDA 30 sections