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cytisine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 5217 | 485-35-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
RN given refers to (R)-isomer; structure
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT2,AXL,BRAF,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,HASPIN,IRAK1,IRAK4,ITK,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK7,MAPKAPK2,MARK4,NTRK1,NTRK2,PDK1,PDK2,PDK4,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,ULK1 | 42 | |||
| kinase-selectivity-class | AKT1,AKT2,AKT3,AXL,CAMK2B,CAMK2D,CHUK,CLK2,EIF2AK3,GAK,HASPIN,IRAK1,IRAK4,MAP3K14,MAP3K7,MAP4K3,PAK4,PDK1,PRKG1,SIK2,STK33,SYK | 22 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | Health Canada |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:38231 | phytotoxin |
| CHEBI has role | CHEBI:47958 | nicotinic acetylcholine receptor agonist |
| CHEBI has role | CHEBI:76924 | plant metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Smoking cessation assistance | indication | 384742004 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.18 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Neuronal acetylcholine receptor subunit alpha-7 | Ion channel | Ki | 5.85 | CHEMBL | |||||
| Acetylcholine receptor subunit delta | Ion channel | EC50 | 4 | CHEMBL | |||||
| Neuronal acetylcholine receptor subunit alpha-4 | Ion channel | Ki | 9.47 | CHEMBL | |||||
| Neuronal acetylcholine receptor subunit alpha-7 | Ion channel | Ki | 9.05 | CHEMBL | |||||
| Acetylcholine receptor subunit alpha | Ion channel | IC50 | 5.45 | CHEMBL | |||||
| Nicotinic acetylcholine receptor alpha 5 subunit | Ion channel | Ki | 5.91 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| C0056913 | UMLSCUI |
| C5E | PDB_CHEM_ID |
| CHEMBL497939 | ChEMBL_ID |
| 10235 | PUBCHEM_CID |
| DB09028 | DRUGBANK_ID |
| D07770 | KEGG_DRUG |
| C004712 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5347 | IUPHAR_LIGAND_ID |
| 76283008 | SNOMEDCT_US |
| CHEBI:4055 | CHEBI |
| 11015 | INN_ID |
| 1723152 | RXNORM |
| 1ZI8CA9FWW | UNII |
| 53S5U404NU | UNII |
| P2U1EM4JMV | UNII |
Pharmaceutical products:
None