ferumoxytol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
5204 722492-56-0

Description:

MoleculeDescription

Synonyms:

  • ferumoxytol
  • rienso
  • ferumoxytol non-stoichiometric magnetite
  • feraheme
Ferumoxytol consists of a superparamagnetic iron oxide that is coated with a carbohydrate shell, which helps to isolate the bioactive iron from plasma components until the iron-carbohydrate complex enters the reticuloendothelial system macrophages of the liver, spleen and bone marrow. The iron is released from the iron-carbohydrate complex within vesicles in the macrophages. Iron then either enters the intracellular storage iron pool (e.g., ferritin) or is transferred to plasma transferrin for transport to erythroid precursor cells for incorporation into hemoglobin.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 15, 2012 EMA Takeda Pharma A/S
June 30, 2009 FDA AMAG PHARMS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Flushing 242.79 53.59 95 2314 74992 63411621
Dyspnoea 202.87 53.59 179 2230 661134 62825479
Anaphylactic reaction 169.86 53.59 71 2338 66029 63420584
Unresponsive to stimuli 161.18 53.59 57 2352 33759 63452854
Infusion related reaction 127.12 53.59 91 2318 245430 63241183
Chest discomfort 104.77 53.59 60 2349 109909 63376704
Back pain 86.86 53.59 75 2334 264070 63222543
Hypersensitivity 72.58 53.59 71 2338 292614 63193999
Hypotension 69.20 53.59 67 2342 272537 63214076
Pulse absent 67.43 53.59 19 2390 5355 63481258
Hyperhidrosis 57.87 53.59 41 2368 107795 63378818
Chest pain 56.45 53.59 54 2355 215905 63270708

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Unresponsive to stimuli 145.82 52.62 50 1263 27519 34928099
Anaphylactic reaction 115.92 52.62 44 1269 32257 34923361
Flushing 97.96 52.62 39 1274 32381 34923237
Hypotension 88.85 52.62 70 1243 221579 34734039
Dyspnoea 79.84 52.62 83 1230 376699 34578919
Infusion related reaction 61.99 52.62 33 1280 53024 34902594
Back pain 58.50 52.62 43 1270 121746 34833872

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Flushing 312.05 48.26 125 3467 88143 79652653
Unresponsive to stimuli 261.14 48.26 97 3495 55691 79685105
Anaphylactic reaction 236.14 48.26 101 3491 83642 79657154
Dyspnoea 235.47 48.26 236 3356 856789 78884007
Infusion related reaction 178.49 48.26 117 3475 230120 79510676
Hypotension 139.81 48.26 132 3460 440185 79300611
Back pain 134.14 48.26 110 3482 304070 79436726
Chest discomfort 128.78 48.26 79 3513 137965 79602831
Pulse absent 104.69 48.26 32 3560 10071 79730725
Hyperhidrosis 98.01 48.26 69 3523 151423 79589373
Chest pain 82.35 48.26 81 3511 282223 79458573
Hypersensitivity 77.87 48.26 76 3516 262163 79478633
Oxygen saturation decreased 65.86 48.26 51 3541 128996 79611800
Dizziness 55.73 48.26 91 3501 526350 79214446
Nausea 55.42 48.26 128 3464 957068 78783728

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA CS M0011718 Iron
FDA EPC N0000177913 Parenteral Iron Replacement
MeSH PA D006397 Hematinics
MeSH PA D006401 Hematologic Agents
MeSH PA D057947 Parenteral Nutrition Solutions
MeSH PA D019999 Pharmaceutical Solutions

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Iron deficiency anemia indication 87522002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4028919 VANDF
C0060274 UMLSCUI
CHEBI:46726 CHEBI
CHEMBL1201867 ChEMBL_ID
DB06215 DRUGBANK_ID
D04177 KEGG_DRUG
D052203 MESH_DESCRIPTOR_UI
166183 MMSL
348766 MMSL
d07459 MMSL
013180 NDDF
442951001 SNOMEDCT_US
442952008 SNOMEDCT_US
49868115 PUBCHEM_CID
473387 RXNORM
CLH5FT6412 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ferumoxytol HUMAN PRESCRIPTION DRUG LABEL 1 0781-3154 INJECTION 510 mg INTRAVENOUS ANDA 27 sections
Ferumoxytol HUMAN PRESCRIPTION DRUG LABEL 1 0781-3154 INJECTION 510 mg INTRAVENOUS ANDA 27 sections
Ferumoxytol HUMAN PRESCRIPTION DRUG LABEL 1 0781-3154 INJECTION 510 mg INTRAVENOUS ANDA 27 sections
Feraheme HUMAN PRESCRIPTION DRUG LABEL 1 59338-775 INJECTION 510 mg INTRAVENOUS NDA 28 sections
Feraheme HUMAN PRESCRIPTION DRUG LABEL 1 59338-775 INJECTION 510 mg INTRAVENOUS NDA 28 sections
Feraheme HUMAN PRESCRIPTION DRUG LABEL 1 59338-775 INJECTION 510 mg INTRAVENOUS NDA 28 sections