carprofen Indications/Contra | FAERs | Orange Book | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| anti-inflammatory agents, ibuprofen derivatives | 518 | 53716-49-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
anti-inflammatory drug (NSAID) of the propionic acid class with selective inhibition of COX-2 versus COX-1
|
Drug dosage:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 31, 1987 | FDA | ROCHE |
FDA Adverse Event Reporting System
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Completed suicide | 21.60 | 0 | 4 | 3 | 31110 | 3354742 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D018712 | Analgesics, Non-Narcotic |
| CHEBI has role | CHEBI:47868 | photosensitizing agent |
| CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory drug |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
| MeSH PA | D018501 | Antirheumatic Agents |
| MeSH PA | D003879 | Dermatologic Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D017319 | Photosensitizing Agents |
| MeSH PA | D011838 | Radiation-Sensitizing Agents |
| MeSH PA | D018689 | Sensory System Agents |
Drug Use (View source of the data)
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.53 | acidic |
| pKa2 | 11.59 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 2 | Enzyme | INHIBITOR | IC50 | 7 | CHEMBL | CHEMBL | |||
| Prostaglandin G/H synthase 1 | Enzyme | IC50 | 4.88 | CHEMBL | |||||
| Fatty-acid amide hydrolase 1 | Enzyme | IC50 | 4.10 | CHEMBL | |||||
| Prostaglandin G/H synthase 1 | Enzyme | IC50 | 4.89 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| C1702507 | UMLSCUI |
| 7141 | IUPHAR_LIGAND_ID |
| D03410 | KEGG_DRUG |
| DB00821 | DRUGBANK_ID |
| 2581 | PUBCHEM_CID |
| 20343 | RXNORM |
| 4025237 | VANDF |
| 424611009 | SNOMEDCT_US |
| N0000179071 | NDFRT |
| N0000171769 | NDFRT |
| 125710006 | SNOMEDCT_US |
| 005102 | NDDF |
| CHEMBL1316 | ChEMBL_ID |
| CHEBI:364453 | CHEBI |
| C007005 | MESH_SUPPLEMENTAL_RECORD_UI |
| FFL0D546HO | UNII |
| 3980 | INN_ID |
| 0LA | PDB_CHEM_ID |
Pharmaceutical products:
None