carprofen indications/contra

Stem definition	Drug id	CAS RN
anti-inflammatory agents, ibuprofen derivatives	518	53716-49-7

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

Ro 205720
Ro-205720
rimadyl
carprofen
carprodyl

anti-inflammatory drug (NSAID) of the propionic acid class with selective inhibition of COX-2 versus COX-1

Molecular weight: 273.72
Formula: C15H12ClNO2
CLOGP: 3.98
LIPINSKI: 0
HAC: 3
HDO: 2
TPSA: 53.09
ALOGS: -4.86
ROTB: 2

Drug dosage:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 31, 1987	FDA	ROCHE

FDA Adverse Event Reporting System

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	21.60	0	4	3	31110	3354742

Pharmacologic Action:

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Source	Code	Description
MeSH PA	D000700	Analgesics
MeSH PA	D018712	Analgesics, Non-Narcotic
CHEBI has role	CHEBI:47868	photosensitizing agent
CHEBI has role	CHEBI:35475	non-steroidal anti-inflammatory drug
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D017319	Photosensitizing Agents
MeSH PA	D011838	Radiation-Sensitizing Agents
MeSH PA	D018689	Sensory System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.53	acidic
pKa2	11.59	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Prostaglandin G/H synthase 2	Enzyme	P35354	PGH2_HUMAN	INHIBITOR	IC50	7		CHEMBL	CHEMBL
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN		IC50	4.88		CHEMBL
Fatty-acid amide hydrolase 1	Enzyme		FAAH1_RAT		IC50	4.10		CHEMBL
Prostaglandin G/H synthase 1	Enzyme		PGH1_SHEEP		IC50	4.89		CHEMBL

External reference:

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ID	Source
C1702507	UMLSCUI
7141	IUPHAR_LIGAND_ID
D03410	KEGG_DRUG
DB00821	DRUGBANK_ID
2581	PUBCHEM_CID
20343	RXNORM
4025237	VANDF
424611009	SNOMEDCT_US
N0000179071	NDFRT
N0000171769	NDFRT
125710006	SNOMEDCT_US
005102	NDDF
CHEMBL1316	ChEMBL_ID
CHEBI:364453	CHEBI
C007005	MESH_SUPPLEMENTAL_RECORD_UI
FFL0D546HO	UNII
3980	INN_ID
0LA	PDB_CHEM_ID

Pharmaceutical products:

None