Stem definition | Drug id | CAS RN |
---|---|---|
anti-inflammatory agents, ibuprofen derivatives | 518 | 53716-49-7 |
None
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 31, 1987 | FDA | ROCHE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 21.60 | 0 | 4 | 3 | 31110 | 3354742 |
Source | Code | Description |
---|---|---|
MeSH PA | D000700 | Analgesics |
MeSH PA | D018712 | Analgesics, Non-Narcotic |
CHEBI has role | CHEBI:47868 | photosensitizing agent |
CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory drug |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
MeSH PA | D018501 | Antirheumatic Agents |
MeSH PA | D003879 | Dermatologic Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D017319 | Photosensitizing Agents |
MeSH PA | D011838 | Radiation-Sensitizing Agents |
MeSH PA | D018689 | Sensory System Agents |
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.53 | acidic |
pKa2 | 11.59 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 2 | Enzyme | INHIBITOR | IC50 | 7 | CHEMBL | CHEMBL | |||
Prostaglandin G/H synthase 1 | Enzyme | IC50 | 4.88 | CHEMBL | |||||
Fatty-acid amide hydrolase 1 | Enzyme | IC50 | 4.10 | CHEMBL | |||||
Prostaglandin G/H synthase 1 | Enzyme | IC50 | 4.89 | CHEMBL |
ID | Source |
---|---|
C1702507 | UMLSCUI |
7141 | IUPHAR_LIGAND_ID |
D03410 | KEGG_DRUG |
DB00821 | DRUGBANK_ID |
2581 | PUBCHEM_CID |
20343 | RXNORM |
4025237 | VANDF |
424611009 | SNOMEDCT_US |
N0000179071 | NDFRT |
N0000171769 | NDFRT |
125710006 | SNOMEDCT_US |
005102 | NDDF |
CHEMBL1316 | ChEMBL_ID |
CHEBI:364453 | CHEBI |
C007005 | MESH_SUPPLEMENTAL_RECORD_UI |
FFL0D546HO | UNII |
3980 | INN_ID |
0LA | PDB_CHEM_ID |
None