carprofen indications/contra

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 518 53716-49-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • Ro 205720
  • Ro-205720
  • rimadyl
  • carprofen
  • carprodyl
anti-inflammatory drug (NSAID) of the propionic acid class with selective inhibition of COX-2 versus COX-1
  • Molecular weight: 273.72
  • Formula: C15H12ClNO2
  • CLOGP: 3.98
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 53.09
  • ALOGS: -4.86
  • ROTB: 2

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 31, 1987 FDA ROCHE

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 21.60 0 4 3 31110 3354742

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
CHEBI has role CHEBI:47868 photosensitizing agent
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D017319 Photosensitizing Agents
MeSH PA D011838 Radiation-Sensitizing Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.53 acidic
pKa2 11.59 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 7 CHEMBL CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 4.88 CHEMBL
Fatty-acid amide hydrolase 1 Enzyme IC50 4.10 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 4.89 CHEMBL

External reference:

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IDSource
C1702507 UMLSCUI
7141 IUPHAR_LIGAND_ID
D03410 KEGG_DRUG
DB00821 DRUGBANK_ID
2581 PUBCHEM_CID
20343 RXNORM
4025237 VANDF
424611009 SNOMEDCT_US
N0000179071 NDFRT
N0000171769 NDFRT
125710006 SNOMEDCT_US
005102 NDDF
CHEMBL1316 ChEMBL_ID
CHEBI:364453 CHEBI
C007005 MESH_SUPPLEMENTAL_RECORD_UI
FFL0D546HO UNII
3980 INN_ID
0LA PDB_CHEM_ID

Pharmaceutical products:

None