efmoroctocog alfa 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
blood coagulation factors 5178 1270012-79-7

Description:

MoleculeDescription

Synonyms:

  • eloctate
  • efmoroctocog alfa
  • elocta
  • efraloctocog alfa
  • BIIB031
consists of factor VIII fused to the Fc domain of IgG1; for treatment of hemophilia A
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Nov. 19, 2015 EMA Swedish Orphan Biovitrum AB

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Haemorrhage 1080.41 75.60 256 821 51114 34904740
Factor VIII inhibition 234.73 75.60 33 1044 293 34955561
Traumatic haemorrhage 227.36 75.60 36 1041 755 34955099
Haemarthrosis 200.35 75.60 40 1037 3219 34952635
Spontaneous haemorrhage 195.02 75.60 28 1049 292 34955562
Limb injury 126.11 75.60 35 1042 11654 34944200
Joint injury 124.87 75.60 33 1044 9140 34946714
Muscle haemorrhage 88.76 75.60 21 1056 3697 34952157

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Haemorrhage 992.37 83.91 221 693 90897 79652577
Traumatic haemorrhage 228.72 83.91 34 880 1299 79742175
Factor VIII inhibition 185.88 83.91 24 890 314 79743160
Haemarthrosis 184.99 83.91 35 879 5777 79737697
Spontaneous haemorrhage 164.70 83.91 24 890 793 79742681
Limb injury 123.70 83.91 34 880 29494 79713980
Joint injury 112.59 83.91 32 882 31303 79712171
Muscle haemorrhage 98.44 83.91 21 893 6279 79737195

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hereditary factor VIII deficiency disease indication 28293008 DOID:12134




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
7PCM518YLR UNII
C3834170 UMLSCUI
CHEMBL4297945 ChEMBL_ID
D10539 KEGG_DRUG
DB11607 DRUGBANK_ID
9680 INN_ID
C587014 MESH_SUPPLEMENTAL_RECORD_UI
1543089 RXNORM
30674 MMSL
015552 NDDF
718943005 SNOMEDCT_US
781174009 SNOMEDCT_US

Pharmaceutical products:

None