eldecalcitol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 5169 104121-92-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • eldecalcitol
  • ED-71
an analog of vitamin D for the treatment of osteoporosis
  • Molecular weight: 490.73
  • Formula: C30H50O5
  • CLOGP: 6.09
  • LIPINSKI: 1
  • HAC: 5
  • HDO: 4
  • TPSA: 90.15
  • ALOGS: -4.67
  • ROTB: 10

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Jan. 21, 2011 PMDA Chugai Pharmaceutical Co., Ltd

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Renal impairment 276.17 21.94 141 6570 105280 90516456
Osteonecrosis of jaw 272.11 21.94 104 6607 38999 90582737
Hypercalcaemia 220.12 21.94 86 6625 34154 90587582
Interstitial lung disease 156.91 21.94 87 6624 76318 90545418
Cerebral infarction 126.98 21.94 54 6657 26542 90595194
Femoral neck fracture 123.51 21.94 41 6670 10192 90611544
Fall 121.53 21.94 163 6548 481647 90140089
Spinal compression fracture 114.96 21.94 43 6668 15135 90606601
Milk-alkali syndrome 109.09 21.94 24 6687 1249 90620487
Osteomyelitis 86.77 21.94 42 6669 27804 90593932
Cardiac failure 84.99 21.94 68 6643 109428 90512308
Hepatic function abnormal 84.92 21.94 49 6662 46239 90575497
Femur fracture 82.46 21.94 48 6663 46034 90575702
Hypocalcaemia 80.80 21.94 46 6665 42322 90579414
Fatigue 66.75 21.94 5 6706 1154018 89467718
Atypical femur fracture 62.87 21.94 22 6689 6399 90615337
Pneumonia bacterial 61.12 21.94 26 6685 12764 90608972
Drug ineffective 55.51 21.94 17 6694 1384281 89237455
Aortic dissection 51.62 21.94 15 6696 2402 90619334
Altered state of consciousness 51.56 21.94 31 6680 31501 90590235
Compression fracture 49.18 21.94 20 6691 8769 90612967
Decreased appetite 44.82 21.94 91 6620 376449 90245287
Acute phase reaction 44.16 21.94 9 6702 323 90621413
Platelet count decreased 43.27 21.94 52 6659 136917 90484819
Pyelonephritis 42.94 21.94 24 6687 21292 90600444
Calculus urinary 42.84 21.94 12 6699 1686 90620050
Blood pressure decreased 42.70 21.94 39 6672 74856 90546880
Haemorrhage subcutaneous 42.54 21.94 14 6697 3382 90618354
Fracture 39.48 21.94 23 6688 22053 90599683
Hypophosphataemia 39.14 21.94 20 6691 14834 90606902
Herpes zoster 38.52 21.94 41 6670 94603 90527133
Anaemia 38.15 21.94 82 6629 352720 90269016
Disseminated intravascular coagulation 37.36 21.94 22 6689 21516 90600220
Pneumocystis jirovecii pneumonia 37.29 21.94 22 6689 21594 90600142
Pancytopenia 35.29 21.94 44 6667 120219 90501517
Drug eruption 34.03 21.94 25 6686 35382 90586354
Hypokalaemia 33.81 21.94 45 6666 131071 90490665
Erythema multiforme 33.75 21.94 17 6694 12229 90609507
Upper respiratory tract inflammation 33.41 21.94 11 6700 2661 90619075
Oesophageal carcinoma recurrent 33.12 21.94 5 6706 28 90621708
Thoracic vertebral fracture 32.50 21.94 13 6698 5461 90616275
Hypercalcaemic nephropathy 31.27 21.94 4 6707 4 90621732
Physical deconditioning 31.19 21.94 10 6701 2225 90619511
Periodontitis 29.47 21.94 11 6700 3842 90617894
Lumbar vertebral fracture 28.63 21.94 13 6698 7445 90614291
Cardiac failure acute 28.38 21.94 15 6696 11914 90609822
Gastric ulcer 27.79 21.94 20 6691 27428 90594308
Heat illness 27.52 21.94 6 6705 299 90621437
Hypomagnesaemia 27.35 21.94 22 6689 35566 90586170
Joint swelling 26.80 21.94 3 6708 503297 90118439
Pemphigoid 26.26 21.94 13 6698 9013 90612723
Pain 25.36 21.94 22 6689 996319 89625417
Subarachnoid haemorrhage 25.19 21.94 16 6695 17888 90603848
Pyrexia 25.14 21.94 106 6605 660379 89961357
Enterocolitis 24.42 21.94 13 6698 10477 90611259
Rhabdomyolysis 24.09 21.94 24 6687 51232 90570504
Blood creatine phosphokinase increased 23.98 21.94 20 6691 34003 90587733
Nephrocalcinosis 23.48 21.94 7 6704 1225 90620511
Dental caries 23.41 21.94 13 6698 11384 90610352
Iron deficiency anaemia 23.40 21.94 17 6694 23645 90598091
Hypochloraemia 21.95 21.94 8 6703 2614 90619122

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 56.10 24.94 34 1390 78428 42541483
Hypercalcaemia 33.88 24.94 15 1409 18043 42601868
Renal impairment 30.66 24.94 27 1397 110201 42509710
Hypocalcaemia 29.32 24.94 16 1408 30157 42589754
Cerebral infarction 26.12 24.94 15 1409 31154 42588757

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Osteonecrosis of jaw 258.28 19.11 107 8337 47910 110532945
Renal impairment 236.21 19.11 158 8286 188287 110392568
Hypercalcaemia 220.99 19.11 95 8349 46562 110534293
Interstitial lung disease 184.55 19.11 121 8323 139213 110441642
Femoral neck fracture 129.23 19.11 45 8399 12522 110568333
Cerebral infarction 123.90 19.11 66 8378 51772 110529083
Spinal compression fracture 116.02 19.11 46 8398 18346 110562509
Fall 101.58 19.11 172 8272 603310 109977545
Milk-alkali syndrome 97.50 19.11 24 8420 1981 110578874
Hypocalcaemia 94.37 19.11 60 8384 65306 110515549
Hepatic function abnormal 84.09 19.11 63 8381 89232 110491623
Cardiac failure 82.77 19.11 86 8358 187540 110393315
Osteomyelitis 80.18 19.11 44 8400 36556 110544299
Femur fracture 80.01 19.11 47 8397 44422 110536433
Fatigue 63.26 19.11 9 8435 1215949 109364906
Atypical femur fracture 62.89 19.11 22 8422 6197 110574658
Drug ineffective 61.48 19.11 20 8424 1520520 109060335
Pneumonia bacterial 58.70 19.11 32 8412 26229 110554626
Decreased appetite 50.76 19.11 112 8332 475734 110105121
Compression fracture 47.50 19.11 20 8424 9279 110571576
Platelet count decreased 47.22 19.11 72 8372 230371 110350484
Upper respiratory tract inflammation 46.27 19.11 16 8428 4355 110576500
Herpes zoster 44.75 19.11 48 8396 108331 110472524
Pyelonephritis 43.61 19.11 26 8418 25224 110555631
Altered state of consciousness 42.04 19.11 35 8409 57591 110523264
Fracture 41.45 19.11 25 8419 24763 110556092
Aortic dissection 40.66 19.11 15 8429 4918 110575937
Acute phase reaction 40.59 19.11 9 8435 470 110580385
Drug eruption 39.99 19.11 33 8411 53626 110527229
Calculus urinary 39.11 19.11 13 8431 3139 110577716
Disseminated intravascular coagulation 38.55 19.11 29 8415 41257 110539598
Hypokalaemia 37.35 19.11 57 8387 182391 110398464
Blood pressure decreased 35.74 19.11 44 8400 115047 110465808
Haemorrhage subcutaneous 35.43 19.11 14 8430 5525 110575330
Anaemia 34.73 19.11 106 8338 546980 110033875
Liver disorder 32.79 19.11 47 8397 142196 110438659
Periodontitis 32.74 19.11 13 8431 5195 110575660
Pneumocystis jirovecii pneumonia 31.26 19.11 26 8418 42709 110538146
Hypercalcaemic nephropathy 31.15 19.11 4 8440 4 110580851
Hypophosphataemia 30.29 19.11 23 8421 33159 110547696
Thoracic vertebral fracture 29.66 19.11 13 8431 6642 110574213
Lumbar vertebral fracture 28.70 19.11 14 8430 9117 110571738
Oesophageal carcinoma recurrent 28.55 19.11 5 8439 75 110580780
Erythema multiforme 27.07 19.11 18 8426 21079 110559776
Pneumonia aspiration 26.75 19.11 32 8412 81201 110499654
Gastric ulcer 26.60 19.11 23 8421 39804 110541051
Enterocolitis 26.35 19.11 17 8427 18932 110561923
Heat illness 26.32 19.11 7 8437 785 110580070
Toxicity to various agents 26.25 19.11 3 8441 480552 110100303
Marasmus 25.15 19.11 8 8436 1683 110579172
Lymphocyte count decreased 24.76 19.11 26 8418 57217 110523638
Iron deficiency anaemia 24.75 19.11 20 8424 31539 110549316
Joint swelling 23.60 19.11 3 8441 442842 110138013
Dehydration 23.45 19.11 60 8384 279451 110301404
Ulna fracture 23.12 19.11 7 8437 1251 110579604
Confusional state 23.08 19.11 4 8440 468676 110112179
Physical deconditioning 22.83 19.11 9 8435 3528 110577327
Hyperuricaemia 22.61 19.11 14 8430 14517 110566338
Radius fracture 21.76 19.11 9 8435 3991 110576864
Dental caries 21.65 19.11 13 8431 12760 110568095
Pyrexia 21.30 19.11 129 8315 898136 109682719
Concomitant disease aggravated 21.09 19.11 14 8430 16350 110564505
Ureterolithiasis 20.93 19.11 9 8435 4393 110576462
Shunt occlusion 20.90 19.11 7 8437 1730 110579125
Nephrocalcinosis 20.60 19.11 7 8437 1807 110579048
Dementia 20.56 19.11 18 8426 31655 110549200
Cardiac failure acute 20.47 19.11 16 8428 24062 110556793
Organising pneumonia 20.35 19.11 13 8431 14230 110566625
Pain 20.24 19.11 26 8418 954929 109625926
White blood cell count decreased 20.03 19.11 50 8394 229340 110351515
Pancytopenia 19.69 19.11 47 8397 209566 110371289
Neutrophil count decreased 19.59 19.11 34 8410 120907 110459948
Lung neoplasm malignant 19.54 19.11 18 8426 33824 110547031
Subarachnoid haemorrhage 19.53 19.11 17 8427 29685 110551170
Hypochloraemia 19.21 19.11 8 8436 3610 110577245

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D050071 Bone Density Conservation Agents
CHEBI has role CHEBI:25212 metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Osteoporosis indication 64859006 DOID:11476




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.2 acidic
pKa2 13.89 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Vitamin D3 receptor Nuclear hormone receptor AGONIST UNKNOWN KEGG DRUG
Vitamin D3 receptor Transcription factor AGONIST Kd 8 IUPHAR

External reference:

IDSource
I2JP8UE90H UNII
D07578 KEGG_DRUG
C2828245 UMLSCUI
CHEBI:73927 CHEBI
ED9 PDB_CHEM_ID
CHEMBL4297608 ChEMBL_ID
6918141 PUBCHEM_CID
DB05295 DRUGBANK_ID
8867 INN_ID
C547512 MESH_SUPPLEMENTAL_RECORD_UI
2783 IUPHAR_LIGAND_ID
I2JP8UE90H INXIGHT DRUGS

Pharmaceutical products:

None