All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

eldecalcitol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
Vitamin D analogues/derivatives	5169	104121-92-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: eldecalcitol ED-71	an analog of vitamin D for the treatment of osteoporosis Molecular weight: 490.73 Formula: C30H50O5 CLOGP: 6.09 LIPINSKI: 1 HAC: 5 HDO: 4 TPSA: 90.15 ALOGS: -4.67 ROTB: 10

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2B,CDK5,EIF2AK3,GRK2,ITK,PDK1,PDK2,PDK4,PRKDC	9
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
Jan. 21, 2011	PMDA	Chugai Pharmaceutical Co., Ltd

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Renal impairment	276.17	21.94	141	6570	105280	90516456
Osteonecrosis of jaw	272.11	21.94	104	6607	38999	90582737
Hypercalcaemia	220.12	21.94	86	6625	34154	90587582
Interstitial lung disease	156.91	21.94	87	6624	76318	90545418
Cerebral infarction	126.98	21.94	54	6657	26542	90595194
Femoral neck fracture	123.51	21.94	41	6670	10192	90611544
Fall	121.53	21.94	163	6548	481647	90140089
Spinal compression fracture	114.96	21.94	43	6668	15135	90606601
Milk-alkali syndrome	109.09	21.94	24	6687	1249	90620487
Osteomyelitis	86.77	21.94	42	6669	27804	90593932
Cardiac failure	84.99	21.94	68	6643	109428	90512308
Hepatic function abnormal	84.92	21.94	49	6662	46239	90575497
Femur fracture	82.46	21.94	48	6663	46034	90575702
Hypocalcaemia	80.80	21.94	46	6665	42322	90579414
Fatigue	66.75	21.94	5	6706	1154018	89467718
Atypical femur fracture	62.87	21.94	22	6689	6399	90615337
Pneumonia bacterial	61.12	21.94	26	6685	12764	90608972
Drug ineffective	55.51	21.94	17	6694	1384281	89237455
Aortic dissection	51.62	21.94	15	6696	2402	90619334
Altered state of consciousness	51.56	21.94	31	6680	31501	90590235
Compression fracture	49.18	21.94	20	6691	8769	90612967
Decreased appetite	44.82	21.94	91	6620	376449	90245287
Acute phase reaction	44.16	21.94	9	6702	323	90621413
Platelet count decreased	43.27	21.94	52	6659	136917	90484819
Pyelonephritis	42.94	21.94	24	6687	21292	90600444
Calculus urinary	42.84	21.94	12	6699	1686	90620050
Blood pressure decreased	42.70	21.94	39	6672	74856	90546880
Haemorrhage subcutaneous	42.54	21.94	14	6697	3382	90618354
Fracture	39.48	21.94	23	6688	22053	90599683
Hypophosphataemia	39.14	21.94	20	6691	14834	90606902
Herpes zoster	38.52	21.94	41	6670	94603	90527133
Anaemia	38.15	21.94	82	6629	352720	90269016
Disseminated intravascular coagulation	37.36	21.94	22	6689	21516	90600220
Pneumocystis jirovecii pneumonia	37.29	21.94	22	6689	21594	90600142
Pancytopenia	35.29	21.94	44	6667	120219	90501517
Drug eruption	34.03	21.94	25	6686	35382	90586354
Hypokalaemia	33.81	21.94	45	6666	131071	90490665
Erythema multiforme	33.75	21.94	17	6694	12229	90609507
Upper respiratory tract inflammation	33.41	21.94	11	6700	2661	90619075
Oesophageal carcinoma recurrent	33.12	21.94	5	6706	28	90621708
Thoracic vertebral fracture	32.50	21.94	13	6698	5461	90616275
Hypercalcaemic nephropathy	31.27	21.94	4	6707	4	90621732
Physical deconditioning	31.19	21.94	10	6701	2225	90619511
Periodontitis	29.47	21.94	11	6700	3842	90617894
Lumbar vertebral fracture	28.63	21.94	13	6698	7445	90614291
Cardiac failure acute	28.38	21.94	15	6696	11914	90609822
Gastric ulcer	27.79	21.94	20	6691	27428	90594308
Heat illness	27.52	21.94	6	6705	299	90621437
Hypomagnesaemia	27.35	21.94	22	6689	35566	90586170
Joint swelling	26.80	21.94	3	6708	503297	90118439
Pemphigoid	26.26	21.94	13	6698	9013	90612723
Pain	25.36	21.94	22	6689	996319	89625417
Subarachnoid haemorrhage	25.19	21.94	16	6695	17888	90603848
Pyrexia	25.14	21.94	106	6605	660379	89961357
Enterocolitis	24.42	21.94	13	6698	10477	90611259
Rhabdomyolysis	24.09	21.94	24	6687	51232	90570504
Blood creatine phosphokinase increased	23.98	21.94	20	6691	34003	90587733
Nephrocalcinosis	23.48	21.94	7	6704	1225	90620511
Dental caries	23.41	21.94	13	6698	11384	90610352
Iron deficiency anaemia	23.40	21.94	17	6694	23645	90598091
Hypochloraemia	21.95	21.94	8	6703	2614	90619122

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Interstitial lung disease	56.10	24.94	34	1390	78428	42541483
Hypercalcaemia	33.88	24.94	15	1409	18043	42601868
Renal impairment	30.66	24.94	27	1397	110201	42509710
Hypocalcaemia	29.32	24.94	16	1408	30157	42589754
Cerebral infarction	26.12	24.94	15	1409	31154	42588757

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Osteonecrosis of jaw	258.28	19.11	107	8337	47910	110532945
Renal impairment	236.21	19.11	158	8286	188287	110392568
Hypercalcaemia	220.99	19.11	95	8349	46562	110534293
Interstitial lung disease	184.55	19.11	121	8323	139213	110441642
Femoral neck fracture	129.23	19.11	45	8399	12522	110568333
Cerebral infarction	123.90	19.11	66	8378	51772	110529083
Spinal compression fracture	116.02	19.11	46	8398	18346	110562509
Fall	101.58	19.11	172	8272	603310	109977545
Milk-alkali syndrome	97.50	19.11	24	8420	1981	110578874
Hypocalcaemia	94.37	19.11	60	8384	65306	110515549
Hepatic function abnormal	84.09	19.11	63	8381	89232	110491623
Cardiac failure	82.77	19.11	86	8358	187540	110393315
Osteomyelitis	80.18	19.11	44	8400	36556	110544299
Femur fracture	80.01	19.11	47	8397	44422	110536433
Fatigue	63.26	19.11	9	8435	1215949	109364906
Atypical femur fracture	62.89	19.11	22	8422	6197	110574658
Drug ineffective	61.48	19.11	20	8424	1520520	109060335
Pneumonia bacterial	58.70	19.11	32	8412	26229	110554626
Decreased appetite	50.76	19.11	112	8332	475734	110105121
Compression fracture	47.50	19.11	20	8424	9279	110571576
Platelet count decreased	47.22	19.11	72	8372	230371	110350484
Upper respiratory tract inflammation	46.27	19.11	16	8428	4355	110576500
Herpes zoster	44.75	19.11	48	8396	108331	110472524
Pyelonephritis	43.61	19.11	26	8418	25224	110555631
Altered state of consciousness	42.04	19.11	35	8409	57591	110523264
Fracture	41.45	19.11	25	8419	24763	110556092
Aortic dissection	40.66	19.11	15	8429	4918	110575937
Acute phase reaction	40.59	19.11	9	8435	470	110580385
Drug eruption	39.99	19.11	33	8411	53626	110527229
Calculus urinary	39.11	19.11	13	8431	3139	110577716
Disseminated intravascular coagulation	38.55	19.11	29	8415	41257	110539598
Hypokalaemia	37.35	19.11	57	8387	182391	110398464
Blood pressure decreased	35.74	19.11	44	8400	115047	110465808
Haemorrhage subcutaneous	35.43	19.11	14	8430	5525	110575330
Anaemia	34.73	19.11	106	8338	546980	110033875
Liver disorder	32.79	19.11	47	8397	142196	110438659
Periodontitis	32.74	19.11	13	8431	5195	110575660
Pneumocystis jirovecii pneumonia	31.26	19.11	26	8418	42709	110538146
Hypercalcaemic nephropathy	31.15	19.11	4	8440	4	110580851
Hypophosphataemia	30.29	19.11	23	8421	33159	110547696
Thoracic vertebral fracture	29.66	19.11	13	8431	6642	110574213
Lumbar vertebral fracture	28.70	19.11	14	8430	9117	110571738
Oesophageal carcinoma recurrent	28.55	19.11	5	8439	75	110580780
Erythema multiforme	27.07	19.11	18	8426	21079	110559776
Pneumonia aspiration	26.75	19.11	32	8412	81201	110499654
Gastric ulcer	26.60	19.11	23	8421	39804	110541051
Enterocolitis	26.35	19.11	17	8427	18932	110561923
Heat illness	26.32	19.11	7	8437	785	110580070
Toxicity to various agents	26.25	19.11	3	8441	480552	110100303
Marasmus	25.15	19.11	8	8436	1683	110579172
Lymphocyte count decreased	24.76	19.11	26	8418	57217	110523638
Iron deficiency anaemia	24.75	19.11	20	8424	31539	110549316
Joint swelling	23.60	19.11	3	8441	442842	110138013
Dehydration	23.45	19.11	60	8384	279451	110301404
Ulna fracture	23.12	19.11	7	8437	1251	110579604
Confusional state	23.08	19.11	4	8440	468676	110112179
Physical deconditioning	22.83	19.11	9	8435	3528	110577327
Hyperuricaemia	22.61	19.11	14	8430	14517	110566338
Radius fracture	21.76	19.11	9	8435	3991	110576864
Dental caries	21.65	19.11	13	8431	12760	110568095
Pyrexia	21.30	19.11	129	8315	898136	109682719
Concomitant disease aggravated	21.09	19.11	14	8430	16350	110564505
Ureterolithiasis	20.93	19.11	9	8435	4393	110576462
Shunt occlusion	20.90	19.11	7	8437	1730	110579125
Nephrocalcinosis	20.60	19.11	7	8437	1807	110579048
Dementia	20.56	19.11	18	8426	31655	110549200
Cardiac failure acute	20.47	19.11	16	8428	24062	110556793
Organising pneumonia	20.35	19.11	13	8431	14230	110566625
Pain	20.24	19.11	26	8418	954929	109625926
White blood cell count decreased	20.03	19.11	50	8394	229340	110351515
Pancytopenia	19.69	19.11	47	8397	209566	110371289
Neutrophil count decreased	19.59	19.11	34	8410	120907	110459948
Lung neoplasm malignant	19.54	19.11	18	8426	33824	110547031
Subarachnoid haemorrhage	19.53	19.11	17	8427	29685	110551170
Hypochloraemia	19.21	19.11	8	8436	3610	110577245

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D050071	Bone Density Conservation Agents
CHEBI has role	CHEBI:25212	metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Osteoporosis	indication	64859006	DOID:11476

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.2	acidic
pKa2	13.89	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Vitamin D3 receptor	Nuclear hormone receptor	P11473	VDR_HUMAN	AGONIST				UNKNOWN	KEGG DRUG
Vitamin D3 receptor	Transcription factor		VDR_RAT	AGONIST	Kd	8		IUPHAR

External reference:

ID	Source
I2JP8UE90H	UNII
D07578	KEGG_DRUG
C2828245	UMLSCUI
CHEBI:73927	CHEBI
ED9	PDB_CHEM_ID
CHEMBL4297608	ChEMBL_ID
6918141	PUBCHEM_CID
DB05295	DRUGBANK_ID
8867	INN_ID
C547512	MESH_SUPPLEMENTAL_RECORD_UI
2783	IUPHAR_LIGAND_ID
I2JP8UE90H	INXIGHT DRUGS

Pharmaceutical products:

None