cefathiamidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, cefalosporanic acid derivatives 5168 33075-00-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cefathiamidine
first generation of cephalosporin antibacterial used for the treatment of respiratory, liver, five senses, urinary tract infections, endocarditis and sepsis
  • Molecular weight: 472.58
  • Formula: C19H28N4O6S2
  • CLOGP: 1.98
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 3
  • TPSA: 137.40
  • ALOGS: -3.61
  • ROTB: 10

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GRK3,GSK3B,ITK,JAK1,JAK2,JAK3,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 57
kinase-selectivity-class AXL,BRAF,CDK9,EPHB4,GRK2,MAP2K6,MAPK7,STK33,TEK 9
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None China Food and Drug Administration (CFDA)

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.39 acidic
pKa2 7.54 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
8M7CAS5T8L UNII
C0054996 UMLSCUI
15942748 PUBCHEM_CID
C018866 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None