carfenazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
516 2622-30-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carphenazine
  • carfenazine
  • carphenazin
  • proketazine
  • carphenazine maleate
  • proketazine maleate
  • Molecular weight: 425.59
  • Formula: C24H31N3O2S
  • CLOGP: 3.44
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 47.02
  • ALOGS: -4.06
  • ROTB: 8

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA WYETH AYERST

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:37930 phenothiazine antipsychotic drugs
CHEBI has role CHEBI:48561 dopaminergic antagonists
CHEBI has role CHEBI:50919 antiemetico

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Chronic schizophrenia indication 83746006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.21 Basic
pKa2 4.21 Basic
pKa3 1.58 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR ANTAGONIST DRUGBANK CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST CHEMBL CHEMBL

External reference:

IDSource
D02644 KEGG_DRUG
C0771221 UMLSCUI
CHEBI:51235 CHEBI
CHEMBL1201328 ChEMBL_ID
CHEMBL2358147 ChEMBL_ID
DB01038 DRUGBANK_ID
7140 IUPHAR_LIGAND_ID
2975-34-0 SECONDARY_CAS_RN
18104 PUBCHEM_CID
123579002 SNOMEDCT_US
782144003 SNOMEDCT_US
1179 INN_ID
CLY16Y8Z7E UNII
001486 NDDF
004593 NDDF

Pharmaceutical products:

None