All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

conestat alfa 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
enzyme inhibitors	5152	80295-38-1

Description:

Molecule	Description
Synonyms: conestat alfa ruconest recombinant human c1-inhibitor	recombinant human complement component 1 (C1) esterase inhibitor (rhC1INH), is an analogue of human C1INH and is obtained from the milk of rabbits expressing the gene encoding for human C1INH, the amino acid sequence of conestat alfa is identical to that of endogenous C1INH Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
3.50	TU	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Oct. 28, 2010	EMA	Pharming Group N.V.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hereditary angioedema	450.36	40.51	71	351	7491	63481109

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hereditary angioedema	75.07	53.12	9	22	1038	34955862

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hereditary angioedema	330.21	42.68	48	248	5287	79738805

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B06AC04	BLOOD AND BLOOD FORMING ORGANS OTHER HEMATOLOGICAL AGENTS OTHER HEMATOLOGICAL AGENTS Drugs used in hereditary angioedema

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hereditary C1 esterase inhibitor deficiency - deficient factor	indication	234619000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
5QS67N4551	UNII
C3195420	UMLSCUI
CHEMBL2108350	ChEMBL_ID
DB09228	DRUGBANK_ID
8899	INN_ID
7627	IUPHAR_LIGAND_ID
1599831	RXNORM
179528	MMSL
27751	MMSL
30530	MMSL
d07742	MMSL
013852	NDDF
429316005	SNOMEDCT_US
713468002	SNOMEDCT_US
725707007	SNOMEDCT_US
C571093	MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ruconest	HUMAN PRESCRIPTION DRUG LABEL	1	69913-350	INJECTION, POWDER, FOR SOLUTION	2100 U	INTRAVENOUS	BLA	24 sections
Ruconest	HUMAN PRESCRIPTION DRUG LABEL	1	69913-350	INJECTION, POWDER, FOR SOLUTION	2100 U	INTRAVENOUS	BLA	24 sections
Ruconest	HUMAN PRESCRIPTION DRUG LABEL	1	70383-350	INJECTION, POWDER, FOR SOLUTION	2100 U	INTRAVENOUS	BLA	24 sections
Ruconest	HUMAN PRESCRIPTION DRUG LABEL	1	71274-350	INJECTION, POWDER, FOR SOLUTION	2100 U	INTRAVENOUS	BLA	23 sections