All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

carperitide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
natriuretic peptides	515	89213-87-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: carperitide human atrial natriuretic peptide atriopeptin carperitide (recombinant)	Molecular weight: 3080.48 Formula: C127H203N45O39S3 CLOGP: LIPINSKI: 3 HAC: 84 HDO: 53 TPSA: 1403.38 ALOGS: -4.44 ROTB: 70

Drug dosage:

None

ADMET properties:

Property	Value	Reference
Vd (Volume of distribution)	0.20 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	25.40 mL/min/kg	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	0.22 hours	Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure	84.92	47.38	28	404	109468	90518547
Hepatic function abnormal	57.41	47.38	17	415	46271	90581744

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure chronic	50.47	35.15	14	621	9587	42611113
Cardiac failure	40.38	35.15	23	612	106833	42513867

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure	103.36	41.39	47	1155	187579	110400518
Renal impairment	78.54	41.39	39	1163	188406	110399691
Cardiac failure chronic	63.67	41.39	17	1185	13794	110574303
Hypernatraemia	59.37	41.39	17	1185	17816	110570281
Hepatic function abnormal	50.98	41.39	23	1179	89272	110498825

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.23	acidic
pKa2	3.93	acidic
pKa3	9.86	acidic
pKa4	12.0	acidic
pKa5	12.06	acidic
pKa6	12.45	acidic
pKa7	12.66	acidic
pKa8	12.66	acidic
pKa9	12.81	acidic
pKa10	13.02	acidic
pKa11	13.03	acidic
pKa12	13.04	acidic
pKa13	13.28	acidic
pKa14	13.37	acidic
pKa15	13.59	acidic
pKa16	13.62	acidic
pKa17	13.62	acidic
pKa18	13.8	acidic
pKa19	13.82	acidic
pKa20	13.89	acidic
pKa21	13.96	acidic
pKa22	11.2	Basic
pKa23	11.0	Basic
pKa24	10.83	Basic
pKa25	10.67	Basic
pKa26	10.5	Basic
pKa27	7.66	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Atrial natriuretic peptide receptor 1	Enzyme	P16066	ANPRA_HUMAN		EC50	10		CHEMBL
Atrial natriuretic peptide receptor 1	Enzyme		ANPRA_RAT		EC50	9		CHEMBL

External reference:

ID	Source
D03328	KEGG_DRUG
C0102586	UMLSCUI
CHEMBL2104386	ChEMBL_ID
C472955	MESH_SUPPLEMENTAL_RECORD_UI
6699	INN_ID
GZ8FA500J0	UNII
16129708	PUBCHEM_CID
DB15591	DRUGBANK_ID
30326004	SNOMEDCT_US
CHEBI:135914	CHEBI

Pharmaceutical products:

None