Stem definition | Drug id | CAS RN |
---|---|---|
5149 | 177073-44-8 |
Molecule | Description |
---|---|
Synonyms:
|
Choriogonadotropin alfa, is an analogue of Luteinizing Hormone (LH) and binds to the LH/hCG receptor of the granulosa and theca cells of the ovary to effect these changes in the absence of an endogenous LH surge. In pregnancy, hCG, secreted by the placenta, maintains the viability of the corpus luteum to provide the continued secretion of estrogen and progesterone necessary to support the first trimester of pregnancy.
|
Dose | Unit | Route |
---|---|---|
0.25 | mg | P |
None
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 20, 2000 | FDA | EMD SERONO |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Ovarian hyperstimulation syndrome | 5188.84 | 46.59 | 732 | 3196 | 3282 | 63481812 |
Ascites | 812.87 | 46.59 | 229 | 3699 | 40499 | 63444595 |
Maternal exposure before pregnancy | 202.97 | 46.59 | 54 | 3874 | 7549 | 63477545 |
Ovarian haemorrhage | 202.81 | 46.59 | 32 | 3896 | 306 | 63484788 |
Abdominal distension | 167.34 | 46.59 | 89 | 3839 | 86526 | 63398568 |
Pelvic fluid collection | 147.08 | 46.59 | 28 | 3900 | 848 | 63484246 |
Adnexal torsion | 144.89 | 46.59 | 25 | 3903 | 429 | 63484665 |
Inappropriate schedule of product administration | 133.89 | 46.59 | 82 | 3846 | 103883 | 63381211 |
Ovarian enlargement | 129.44 | 46.59 | 23 | 3905 | 471 | 63484623 |
Haemoperitoneum | 120.39 | 46.59 | 29 | 3899 | 2712 | 63482382 |
Pleural effusion | 96.23 | 46.59 | 64 | 3864 | 93146 | 63391948 |
Abortion spontaneous | 95.23 | 46.59 | 50 | 3878 | 47145 | 63437949 |
Abdominal pain lower | 81.23 | 46.59 | 37 | 3891 | 25641 | 63459453 |
Multiple pregnancy | 76.24 | 46.59 | 11 | 3917 | 53 | 63485041 |
Effusion | 69.41 | 46.59 | 17 | 3911 | 1701 | 63483393 |
Intra-abdominal haemorrhage | 68.04 | 46.59 | 18 | 3910 | 2451 | 63482643 |
Ectopic pregnancy | 67.35 | 46.59 | 18 | 3910 | 2549 | 63482545 |
Infrequent bowel movements | 58.32 | 46.59 | 14 | 3914 | 1288 | 63483806 |
Abdominal pain | 55.80 | 46.59 | 79 | 3849 | 293377 | 63191717 |
Ovarian cyst ruptured | 54.26 | 46.59 | 13 | 3915 | 1186 | 63483908 |
Poor response to ovulation induction | 52.15 | 46.59 | 6 | 3922 | 0 | 63485094 |
Haemoconcentration | 46.64 | 46.59 | 8 | 3920 | 132 | 63484962 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Product packaging quantity issue | 237.71 | 96.29 | 35 | 527 | 894 | 34955475 |
No adverse event | 208.18 | 96.29 | 52 | 510 | 22875 | 34933494 |
Product dose omission issue | 169.40 | 96.29 | 65 | 497 | 119646 | 34836723 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Ovarian hyperstimulation syndrome | 4658.71 | 48.57 | 630 | 2871 | 2941 | 79737946 |
Ascites | 704.45 | 48.57 | 218 | 3283 | 75344 | 79665543 |
Ovarian haemorrhage | 200.51 | 48.57 | 30 | 3471 | 286 | 79740601 |
Pelvic fluid collection | 158.56 | 48.57 | 28 | 3473 | 791 | 79740096 |
Adnexal torsion | 150.42 | 48.57 | 24 | 3477 | 359 | 79740528 |
Ovarian enlargement | 144.09 | 48.57 | 23 | 3478 | 345 | 79740542 |
Abdominal distension | 138.45 | 48.57 | 78 | 3423 | 119572 | 79621315 |
Maternal exposure before pregnancy | 111.81 | 48.57 | 28 | 3473 | 4345 | 79736542 |
Haemoperitoneum | 97.18 | 48.57 | 25 | 3476 | 4318 | 79736569 |
Pleural effusion | 85.83 | 48.57 | 62 | 3439 | 145200 | 79595687 |
Multiple pregnancy | 75.09 | 48.57 | 10 | 3491 | 36 | 79740851 |
Effusion | 70.93 | 48.57 | 17 | 3484 | 2197 | 79738690 |
Abdominal pain lower | 69.77 | 48.57 | 32 | 3469 | 31750 | 79709137 |
Product packaging quantity issue | 62.60 | 48.57 | 14 | 3487 | 1335 | 79739552 |
Ovarian cyst ruptured | 61.50 | 48.57 | 13 | 3488 | 953 | 79739934 |
Abdominal pain | 56.47 | 48.57 | 77 | 3424 | 389492 | 79351395 |
No adverse event | 53.31 | 48.57 | 28 | 3473 | 37164 | 79703723 |
Intra-abdominal haemorrhage | 50.04 | 48.57 | 15 | 3486 | 4525 | 79736362 |
None
Source | Code | Description |
---|---|---|
ATC | G03GA08 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM GONADOTROPINS AND OTHER OVULATION STIMULANTS Gonadotropins |
FDA CS | M0009540 | Gonadotropins |
FDA EPC | N0000175838 | Gonadotropin |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Ulcerative colitis | indication | 64766004 | DOID:8577 |
None
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Lutropin-choriogonadotropic hormone receptor | GPCR | AGONIST | CHEMBL | CHEMBL |
ID | Source |
---|---|
6413W06WR3 | UNII |
4021245 | VANDF |
C0937609 | UMLSCUI |
CHEMBL1201464 | ChEMBL_ID |
D03478 | KEGG_DRUG |
DB00097 | DRUGBANK_ID |
7473 | INN_ID |
C412828 | MESH_SUPPLEMENTAL_RECORD_UI |
283550 | RXNORM |
15777 | MMSL |
38355 | MMSL |
009029 | NDDF |
129494006 | SNOMEDCT_US |
391878002 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Ovidrel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44087-1150 | INJECTION, SOLUTION | 250 ug | SUBCUTANEOUS | BLA | 23 sections |