technetium Tc 99m mebrofenin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diagnostic aids; (phenylcarbamoyl)methyl iminodiacetic acid derivatives	5119	221296-35-1

Description:

Molecule	Description
Synonyms: technetium Tc 99m mebrofenin choletec 99mTc mebrofenin technetium Tc-99m mebrofenin	A radioconjugate composed of the iminodiacetic acid derivative mebrofenin bound to an isotope of the synthetic element technetium (Tc). Upon administration and rapid clearance from the circulation, technetium Tc 99m mebrofenin is secreted into the hepatobiliary system, emitting gamma rays that are detectable with planar scintigraphy or single photon emission computer tomography (SPECT). Mebrofenin has no pharmacological effect at the recommended dosage for diagnostic imagining. Molecular weight: 869.33 Formula: C30H34Br2N4O10Tc CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 163.40 ALOGS: ROTB: None

Molecule

Description

Synonyms:

technetium Tc 99m mebrofenin
choletec
99mTc mebrofenin
technetium Tc-99m mebrofenin

A radioconjugate composed of the iminodiacetic acid derivative mebrofenin bound to an isotope of the synthetic element technetium (Tc). Upon administration and rapid clearance from the circulation, technetium Tc 99m mebrofenin is secreted into the hepatobiliary system, emitting gamma rays that are detectable with planar scintigraphy or single photon emission computer tomography (SPECT). Mebrofenin has no pharmacological effect at the recommended dosage for diagnostic imagining.

Molecular weight: 869.33
Formula: C30H34Br2N4O10Tc
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 163.40
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Jan. 21, 1987	FDA	BRACCO

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple use of single-use product	185.42	112.59	21	38	1471	63487492

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple use of single-use product	262.44	90.74	28	62	896	79743402
Therapeutic product effect decreased	123.00	90.74	29	61	163834	79580464

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
FDA MoA	N0000000205	Radiopharmaceutical Activity
MeSH PA	D064907	Diagnostic Uses of Chemicals
MeSH PA	D007202	Indicators and Reagents
MeSH PA	D019275	Radiopharmaceuticals
FDA EPC	N0000177914	Radioactive Diagnostic Agent

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
F2NQ468L52	UNII
D06037	KEGG_DRUG
C0075962	UMLSCUI
CHEMBL1200421	ChEMBL_ID
11431716	PUBCHEM_CID
DB09137	DRUGBANK_ID
C034837	MESH_SUPPLEMENTAL_RECORD_UI
192666	MMSL
4832001	SNOMEDCT_US

Pharmaceutical products:

None