carubicin indications/contra

Stem definitionDrug idCAS RN
antineoplastics, daunorubicin derivatives 510 50935-04-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carminomycin
  • Carminomycin I
  • Carminomicin I
  • carminomicin
  • carubicin
  • carubicin hydrochloride
  • carubicin HCl
A very toxic anthracycline-type antineoplastic related to DAUNORUBICIN, obtained from Actinomadura carminata.
  • Molecular weight: 513.50
  • Formula: C26H27NO10
  • CLOGP: 0.74
  • LIPINSKI: 3
  • HAC: 11
  • HDO: 6
  • TPSA: 196.84
  • ALOGS: -2.59
  • ROTB: 3

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D000903 Antibiotics, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors
MeSH PA D059003 Topoisomerase Inhibitors
CHEBI has role CHEBI:35610 antineoplastic agent

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.89 acidic
pKa2 10.98 acidic
pKa3 11.29 acidic
pKa4 11.9 acidic
pKa5 8.6 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
DNA topoisomerase 2-alpha Enzyme WOMBAT-PK

External reference:

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IDSource
D03414 KEGG_DRUG
4V3R166MB3 UNII
52794-97-5 SECONDARY_CAS_RN
N0000168463 NDFRT
443831 PUBCHEM_CID
CHEMBL474260 ChEMBL_ID
D002360 MESH_DESCRIPTOR_UI
4552 INN_ID
CHEMBL2104443 ChEMBL_ID
CHEMBL2110620 ChEMBL_ID
CHEBI:31359 CHEBI

Pharmaceutical products:

None