carisoprodol indications/contra

Stem definitionDrug idCAS RN
509 78-44-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carisoprodol
  • carisoprodate
  • isomeprobamate
  • isopropyl meprobamate
A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1202)
  • Molecular weight: 260.33
  • Formula: C12H24N2O4
  • CLOGP: 2.34
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 90.65
  • ALOGS: -2.52
  • ROTB: 9

Drug dosage:

DoseUnitRoute
1.40 g O

Approvals:

DateAgencyCompanyOrphan
April 9, 1959 FDA MEDA PHARMS

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 4466.71 65.18 930 1608 30184 3353137
Respiratory arrest 1852.86 65.18 386 2152 10982 3372339
Toxicity to various agents 1659.93 65.18 463 2075 46591 3336730
Cardiac arrest 1556.07 65.18 394 2144 26925 3356396
Cardio-respiratory arrest 1054.34 65.18 259 2279 15181 3368140
Drug abuse 970.76 65.18 251 2287 18079 3365242
Overdose 787.47 65.18 244 2294 33734 3349587
Poisoning 618.14 65.18 137 2401 4975 3378346
Intentional product misuse 457.50 65.18 129 2409 12572 3370749
Intentional overdose 395.30 65.18 120 2418 15105 3368216
Accidental overdose 386.23 65.18 100 2438 7018 3376303
Death 306.59 65.18 196 2342 152128 3231193
Coma 210.03 65.18 71 2467 12481 3370840
Unresponsive to stimuli 206.71 65.18 63 2475 7945 3375376
Drug hypersensitivity 174.25 65.18 83 2455 35597 3347724
Exposure via ingestion 152.54 65.18 35 2503 1458 3381863
Somnolence 130.41 65.18 66 2472 32138 3351183
Drug dependence 123.85 65.18 37 2501 4339 3378982
Drug abuser 122.42 65.18 33 2505 2670 3380651
Road traffic accident 103.27 65.18 36 2502 6890 3376431
Accidental death 98.57 65.18 21 2517 617 3382704
Depressed level of consciousness 95.80 65.18 39 2499 11426 3371895
Blood pH decreased 86.67 65.18 20 2518 852 3382469
Poisoning deliberate 83.34 65.18 20 2518 1011 3382310
Substance abuse 80.46 65.18 20 2518 1172 3382149
Drug screen positive 80.10 65.18 22 2516 1906 3381415
Pneumonia aspiration 76.38 65.18 29 2509 7059 3376262
Respiratory rate decreased 75.49 65.18 18 2520 885 3382436
Lethargy 72.44 65.18 34 2504 13981 3369340
Suicide attempt 71.45 65.18 35 2503 15812 3367509

Pharmacologic Action:

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SourceCodeDescription
ATC M03BA02 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Carbamic acid esters
ATC M03BA52 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Carbamic acid esters
ATC M03BA72 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Carbamic acid esters
FDA PE N0000175730 Centrally-mediated Muscle Relaxation
CHEBI has role CHEBI:51371 muscle relaxant
MeSH PA D002491 Central Nervous System Agents
MeSH PA D009125 Muscle Relaxants, Central
MeSH PA D009465 Neuromuscular Agents
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Backache indication 161891005
Spasticity indication 221360009
Muscle Spasm with Pain indication
Dependent drug abuse contraindication 6525002
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Lowered convulsive threshold contraindication 19260006
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Alcohol intoxication contraindication 25702006
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Acute nephropathy contraindication 58574008
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Sedation contraindication 72641008
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Epilepsy contraindication 84757009 DOID:1826
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:2527
Hemophilia contraindication 90935002
Anemia due to enzyme deficiency contraindication 111577008
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
von Willebrand disorder contraindication 128105004 DOID:12531
Acute intermittent porphyria contraindication 234422006 DOID:3890
Disease of liver contraindication 235856003 DOID:409
Benign prostatic hyperplasia contraindication 266569009 DOID:2883
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Primary adrenocortical insufficiency contraindication 373662000 DOID:13774
Operation on gastrointestinal tract contraindication 386621005
Pseudomembranous enterocolitis contraindication 397683000 DOID:0060185
Breastfeeding (mother) contraindication 413712001
Central nervous system depression contraindication 418072004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Poor metabolizer due to cytochrome p450 CYP2C19 variant contraindication 424500005
Dysfunction of sphincter of Oddi contraindication 430887001
Acute erosive gastritis contraindication 444926003
Acute exacerbation of asthma contraindication 708038006

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
DB00395 DRUGBANK_ID
4018454 VUID
N0000146778 NUI
C0007248 UMLSCUI
7610 IUPHAR_LIGAND_ID
D00768 KEGG_DRUG
21925K482H UNII
902 INN_ID
2576 PUBCHEM_CID
4018454 VANDF
N0000146778 NDFRT
N0000006668 NDFRT
001672 NDDF
747 MMSL
2101 RXNORM
25076002 SNOMEDCT_US
387133006 SNOMEDCT_US
4359 MMSL
d00960 MMSL
CHEMBL1233 ChEMBL_ID
CHEBI:3419 CHEBI
D002328 MESH_DESCRIPTOR_UI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Soma HUMAN PRESCRIPTION DRUG LABEL 1 0037-2001 TABLET 350 mg ORAL NDA 17 sections
Soma HUMAN PRESCRIPTION DRUG LABEL 1 0037-2250 TABLET 250 mg ORAL NDA 17 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 0143-1176 TABLET 350 mg ORAL ANDA 17 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 0143-9749 TABLET 350 mg ORAL ANDA 18 sections
Carisoprodol and Aspirin HUMAN PRESCRIPTION DRUG LABEL 2 0185-0724 TABLET 200 mg ORAL ANDA 12 sections
Carisoprodol, Aspirin and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 3 0185-0749 TABLET 200 mg ORAL ANDA 14 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 0591-5513 TABLET 350 mg ORAL ANDA 17 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 0603-2582 TABLET 350 mg ORAL ANDA 17 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 10544-033 TABLET 350 mg ORAL ANDA 17 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 10544-088 TABLET 350 mg ORAL ANDA 18 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 10544-132 TABLET 350 mg ORAL ANDA 18 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 12634-437 TABLET 350 mg ORAL ANDA 17 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 16590-039 TABLET 350 mg ORAL ANDA 18 sections
SOMA HUMAN PRESCRIPTION DRUG LABEL 1 16590-755 TABLET 250 mg ORAL NDA 18 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 16714-510 TABLET 350 mg ORAL ANDA 18 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL WITH HIGHLIGHTS 1 21695-021 TABLET 350 mg ORAL ANDA 18 sections
Carisoprodol and Aspirin HUMAN PRESCRIPTION DRUG LABEL 2 21695-570 TABLET 200 mg ORAL ANDA 12 sections
Soma HUMAN PRESCRIPTION DRUG LABEL 1 21695-606 TABLET 250 mg ORAL NDA 18 sections
Carisoprodol and Aspirin HUMAN PRESCRIPTION DRUG LABEL 2 23155-145 TABLET 200 mg ORAL ANDA 12 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 29033-207 TABLET 250 mg ORAL ANDA 17 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 33261-387 TABLET 350 mg ORAL ANDA 18 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 33358-064 TABLET 350 mg ORAL ANDA 18 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 35356-721 TABLET 350 mg ORAL ANDA 18 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 35356-805 TABLET 350 mg ORAL ANDA 19 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 42543-434 TABLET 250 mg ORAL ANDA 17 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 42543-700 TABLET 350 mg ORAL ANDA 17 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 42549-503 TABLET 350 mg ORAL ANDA 18 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 43063-302 TABLET 350 mg ORAL ANDA 17 sections
Carisoprodol HUMAN PRESCRIPTION DRUG LABEL 1 43063-824 TABLET 350 mg ORAL ANDA 18 sections
CARISOPRODOL HUMAN PRESCRIPTION DRUG LABEL 1 43353-102 TABLET 350 mg ORAL ANDA 18 sections