| Stem definition | Drug id | CAS RN |
|---|---|---|
| enzymes | 5082 | 130167-69-0 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
covalent attachment of PEG to enzyme produces active, stable complex; non-immunogenic; used in treatment of leukemia
|
None
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Feb. 1, 1994 | FDA | SIGMA TAU |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Febrile neutropenia | 1082.16 | 28.58 | 484 | 10378 | 117965 | 63360195 |
| Febrile bone marrow aplasia | 920.42 | 28.58 | 220 | 10642 | 7105 | 63471055 |
| Hypofibrinogenaemia | 442.03 | 28.58 | 87 | 10775 | 1083 | 63477077 |
| Hypertriglyceridaemia | 296.99 | 28.58 | 87 | 10775 | 6172 | 63471988 |
| Hyperbilirubinaemia | 190.53 | 28.58 | 72 | 10790 | 11242 | 63466918 |
| Blood culture positive | 161.19 | 28.58 | 51 | 10811 | 4684 | 63473476 |
| Neutropenia | 152.58 | 28.58 | 168 | 10694 | 174837 | 63303323 |
| Rhinovirus infection | 134.59 | 28.58 | 44 | 10818 | 4485 | 63473675 |
| Superior sagittal sinus thrombosis | 121.47 | 28.58 | 28 | 10834 | 763 | 63477397 |
| Sepsis | 121.44 | 28.58 | 140 | 10722 | 152983 | 63325177 |
| Pancreatitis | 111.27 | 28.58 | 81 | 10781 | 48974 | 63429186 |
| Human bocavirus infection | 110.16 | 28.58 | 23 | 10839 | 390 | 63477770 |
| Pyrexia | 109.46 | 28.58 | 245 | 10617 | 470233 | 63007927 |
| Bacterial infection | 108.25 | 28.58 | 57 | 10805 | 19442 | 63458718 |
| Hepatocellular injury | 108.18 | 28.58 | 64 | 10798 | 27317 | 63450843 |
| Posterior reversible encephalopathy syndrome | 99.98 | 28.58 | 52 | 10810 | 17293 | 63460867 |
| Drug ineffective | 98.05 | 28.58 | 29 | 10833 | 1044736 | 62433424 |
| Septic shock | 95.41 | 28.58 | 84 | 10778 | 66545 | 63411615 |
| Mucosal inflammation | 91.97 | 28.58 | 71 | 10791 | 46857 | 63431303 |
| Enterobacter infection | 88.46 | 28.58 | 27 | 10835 | 2200 | 63475960 |
| Venoocclusive liver disease | 85.85 | 28.58 | 32 | 10830 | 4803 | 63473357 |
| Mucormycosis | 85.73 | 28.58 | 28 | 10834 | 2843 | 63475317 |
| Pyomyositis | 83.54 | 28.58 | 18 | 10844 | 357 | 63477803 |
| Hyperglycaemia | 81.28 | 28.58 | 63 | 10799 | 41804 | 63436356 |
| Human herpesvirus 6 infection | 80.92 | 28.58 | 27 | 10835 | 2930 | 63475230 |
| Colitis | 79.28 | 28.58 | 66 | 10796 | 48462 | 63429698 |
| Lipase increased | 78.86 | 28.58 | 37 | 10825 | 9863 | 63468297 |
| Secondary immunodeficiency | 77.97 | 28.58 | 22 | 10840 | 1361 | 63476799 |
| Perineal necrosis | 76.59 | 28.58 | 14 | 10848 | 113 | 63478047 |
| Herpes simplex | 75.56 | 28.58 | 34 | 10828 | 8237 | 63469923 |
| Perineal infection | 74.07 | 28.58 | 14 | 10848 | 138 | 63478022 |
| Pneumatosis intestinalis | 73.95 | 28.58 | 24 | 10838 | 2389 | 63475771 |
| Blood fibrinogen decreased | 73.67 | 28.58 | 19 | 10843 | 834 | 63477326 |
| Gastroenteritis norovirus | 73.39 | 28.58 | 23 | 10839 | 2045 | 63476115 |
| Hypotension | 71.19 | 28.58 | 149 | 10713 | 272455 | 63205705 |
| Potentiating drug interaction | 67.13 | 28.58 | 26 | 10836 | 4330 | 63473830 |
| Bacteraemia | 61.91 | 28.58 | 38 | 10824 | 17310 | 63460850 |
| Fatigue | 61.87 | 28.58 | 38 | 10824 | 887990 | 62590170 |
| Pseudomonas test positive | 61.40 | 28.58 | 16 | 10846 | 732 | 63477428 |
| Venous thrombosis | 60.74 | 28.58 | 25 | 10837 | 4877 | 63473283 |
| Antithrombin III decreased | 60.61 | 28.58 | 13 | 10849 | 252 | 63477908 |
| Neurotoxicity | 57.55 | 28.58 | 36 | 10826 | 16954 | 63461206 |
| Thrombocytopenia | 57.33 | 28.58 | 97 | 10765 | 151060 | 63327100 |
| Antithrombin III | 54.52 | 28.58 | 11 | 10851 | 156 | 63478004 |
| Fusarium infection | 53.90 | 28.58 | 14 | 10848 | 632 | 63477528 |
| Tachycardia | 53.22 | 28.58 | 82 | 10780 | 118074 | 63360086 |
| Hypoalbuminaemia | 53.00 | 28.58 | 30 | 10832 | 11775 | 63466385 |
| Clostridium test positive | 52.52 | 28.58 | 20 | 10842 | 3181 | 63474979 |
| Blood bilirubin increased | 51.49 | 28.58 | 46 | 10816 | 37094 | 63441066 |
| Anaphylactic reaction | 48.23 | 28.58 | 58 | 10804 | 66042 | 63412118 |
| Pancytopenia | 47.52 | 28.58 | 70 | 10792 | 96863 | 63381297 |
| Human rhinovirus test positive | 47.17 | 28.58 | 10 | 10852 | 183 | 63477977 |
| Seizure | 46.20 | 28.58 | 82 | 10780 | 132552 | 63345608 |
| Transverse sinus thrombosis | 46.11 | 28.58 | 12 | 10850 | 546 | 63477614 |
| Bone marrow failure | 46.09 | 28.58 | 39 | 10823 | 29251 | 63448909 |
| Pulmonary haemorrhage | 45.63 | 28.58 | 23 | 10839 | 7158 | 63471002 |
| Cerebral venous thrombosis | 45.31 | 28.58 | 16 | 10846 | 2058 | 63476102 |
| Hepatic failure | 45.19 | 28.58 | 42 | 10820 | 35614 | 63442546 |
| Device related infection | 44.95 | 28.58 | 35 | 10827 | 23357 | 63454803 |
| Arthralgia | 44.50 | 28.58 | 21 | 10841 | 569689 | 62908471 |
| Alanine aminotransferase increased | 43.91 | 28.58 | 70 | 10792 | 103700 | 63374460 |
| Acute lymphocytic leukaemia recurrent | 43.90 | 28.58 | 16 | 10846 | 2253 | 63475907 |
| Respiratory distress | 43.05 | 28.58 | 40 | 10822 | 33911 | 63444249 |
| Pseudomonal sepsis | 43.02 | 28.58 | 16 | 10846 | 2385 | 63475775 |
| Blood lactic acid increased | 43 | 28.58 | 22 | 10840 | 7064 | 63471096 |
| Neuropathy peripheral | 40.52 | 28.58 | 71 | 10791 | 113596 | 63364564 |
| Clostridium difficile colitis | 40.00 | 28.58 | 31 | 10831 | 20538 | 63457622 |
| Cholestasis | 39.89 | 28.58 | 36 | 10826 | 29398 | 63448762 |
| Enteritis | 39.76 | 28.58 | 22 | 10840 | 8264 | 63469896 |
| Hyperlipidaemia | 39.16 | 28.58 | 30 | 10832 | 19541 | 63458619 |
| Neutrophil count decreased | 38.72 | 28.58 | 48 | 10814 | 56358 | 63421802 |
| Blood triglycerides increased | 38.65 | 28.58 | 25 | 10837 | 12463 | 63465697 |
| Drug intolerance | 38.60 | 28.58 | 4 | 10858 | 308657 | 63169503 |
| Pancreatitis acute | 38.35 | 28.58 | 34 | 10828 | 27132 | 63451028 |
| Escherichia test positive | 35.92 | 28.58 | 14 | 10848 | 2370 | 63475790 |
| Streptococcus test positive | 35.86 | 28.58 | 12 | 10850 | 1313 | 63476847 |
| Perirectal abscess | 35.84 | 28.58 | 11 | 10851 | 912 | 63477248 |
| Coagulopathy | 35.74 | 28.58 | 29 | 10833 | 20515 | 63457645 |
| Abdominal discomfort | 35.73 | 28.58 | 6 | 10856 | 320879 | 63157281 |
| Disseminated intravascular coagulation | 35.51 | 28.58 | 28 | 10834 | 19023 | 63459137 |
| Pain | 35.44 | 28.58 | 45 | 10817 | 740583 | 62737577 |
| Quadriparesis | 34.45 | 28.58 | 13 | 10849 | 2016 | 63476144 |
| Pruritus | 33.74 | 28.58 | 10 | 10852 | 361443 | 63116717 |
| Rhinocerebral mucormycosis | 33.64 | 28.58 | 9 | 10853 | 456 | 63477704 |
| Staphylococcal bacteraemia | 33.07 | 28.58 | 17 | 10845 | 5513 | 63472647 |
| Fall | 32.92 | 28.58 | 13 | 10849 | 392321 | 63085839 |
| Rash | 32.46 | 28.58 | 29 | 10833 | 560842 | 62917318 |
| Fungaemia | 32.32 | 28.58 | 13 | 10849 | 2390 | 63475770 |
| Staphylococcal sepsis | 32.09 | 28.58 | 19 | 10843 | 8109 | 63470051 |
| Enterovirus test positive | 31.75 | 28.58 | 7 | 10855 | 155 | 63478005 |
| Respiratory failure | 31.69 | 28.58 | 60 | 10802 | 101798 | 63376362 |
| Cerebral venous sinus thrombosis | 31.20 | 28.58 | 12 | 10850 | 1960 | 63476200 |
| Post lumbar puncture syndrome | 31.14 | 28.58 | 9 | 10853 | 607 | 63477553 |
| Weight increased | 31.05 | 28.58 | 4 | 10858 | 260788 | 63217372 |
| Hyperglycaemic hyperosmolar nonketotic syndrome | 30.97 | 28.58 | 10 | 10852 | 979 | 63477181 |
| Multiple organ dysfunction syndrome | 30.75 | 28.58 | 43 | 10819 | 56709 | 63421451 |
| Enterovirus infection | 30.72 | 28.58 | 10 | 10852 | 1004 | 63477156 |
| Ileus | 30.40 | 28.58 | 23 | 10839 | 14702 | 63463458 |
| Endophthalmitis | 30.39 | 28.58 | 14 | 10848 | 3578 | 63474582 |
| Enterocolitis | 30.06 | 28.58 | 18 | 10844 | 7840 | 63470320 |
| Pseudomonal bacteraemia | 29.72 | 28.58 | 11 | 10851 | 1617 | 63476543 |
| Escherichia bacteraemia | 29.35 | 28.58 | 14 | 10848 | 3869 | 63474291 |
| Pancreatitis necrotising | 29.18 | 28.58 | 11 | 10851 | 1701 | 63476459 |
| Cystitis bacterial | 29.13 | 28.58 | 7 | 10855 | 229 | 63477931 |
| Breakthrough pain | 28.70 | 28.58 | 10 | 10852 | 1236 | 63476924 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Febrile neutropenia | 951.98 | 22.62 | 627 | 13756 | 136222 | 34806326 |
| Hypofibrinogenaemia | 577.91 | 22.62 | 135 | 14248 | 1551 | 34940997 |
| Hypertriglyceridaemia | 426.51 | 22.62 | 152 | 14231 | 8296 | 34934252 |
| Febrile bone marrow aplasia | 423.15 | 22.62 | 150 | 14233 | 8059 | 34934489 |
| Hyperbilirubinaemia | 303.52 | 22.62 | 145 | 14238 | 16698 | 34925850 |
| Mucosal inflammation | 165.94 | 22.62 | 133 | 14250 | 38489 | 34904059 |
| Pancreatitis | 152.51 | 22.62 | 127 | 14256 | 38764 | 34903784 |
| Venoocclusive liver disease | 132.58 | 22.62 | 65 | 14318 | 7901 | 34934647 |
| Neutropenia | 122.77 | 22.62 | 226 | 14157 | 156552 | 34785996 |
| Anaphylactic reaction | 117.40 | 22.62 | 101 | 14282 | 32200 | 34910348 |
| Death | 116.13 | 22.62 | 14 | 14369 | 398035 | 34544513 |
| Vomiting | 95.03 | 22.62 | 269 | 14114 | 247352 | 34695196 |
| Blood fibrinogen decreased | 88.94 | 22.62 | 29 | 14354 | 1201 | 34941347 |
| Abdominal pain | 86.81 | 22.62 | 201 | 14182 | 163417 | 34779131 |
| Coagulopathy | 84.59 | 22.62 | 68 | 14315 | 19721 | 34922827 |
| Hepatotoxicity | 75.64 | 22.62 | 66 | 14317 | 21419 | 34921129 |
| Pancreatitis acute | 74.98 | 22.62 | 74 | 14309 | 28067 | 34914481 |
| Cerebral venous sinus thrombosis | 74.72 | 22.62 | 21 | 14362 | 520 | 34942028 |
| Posterior reversible encephalopathy syndrome | 74.31 | 22.62 | 48 | 14335 | 9906 | 34932642 |
| Gallbladder oedema | 70.49 | 22.62 | 17 | 14366 | 225 | 34942323 |
| Blood bilirubin increased | 69.16 | 22.62 | 82 | 14301 | 38214 | 34904334 |
| Lentigo | 67.06 | 22.62 | 19 | 14364 | 485 | 34942063 |
| Hepatic steatosis | 63.81 | 22.62 | 56 | 14327 | 18306 | 34924242 |
| Hepatocellular injury | 62.14 | 22.62 | 60 | 14323 | 22151 | 34920397 |
| Cerebral thrombosis | 61.91 | 22.62 | 21 | 14362 | 984 | 34941564 |
| Sepsis | 61.82 | 22.62 | 179 | 14204 | 166382 | 34776166 |
| Leukoencephalopathy | 60.15 | 22.62 | 31 | 14352 | 4184 | 34938364 |
| Colitis | 58.75 | 22.62 | 75 | 14308 | 37675 | 34904873 |
| Potentiating drug interaction | 58.05 | 22.62 | 32 | 14351 | 4945 | 34937603 |
| Cholestasis | 55.90 | 22.62 | 62 | 14321 | 26886 | 34915662 |
| Tachycardia | 54.92 | 22.62 | 113 | 14270 | 84659 | 34857889 |
| Hyperglycaemia | 54.57 | 22.62 | 74 | 14309 | 39406 | 34903142 |
| Superior sagittal sinus thrombosis | 53.62 | 22.62 | 14 | 14369 | 260 | 34942288 |
| Ascites | 52.19 | 22.62 | 79 | 14304 | 46492 | 34896056 |
| Alanine aminotransferase increased | 51.50 | 22.62 | 107 | 14276 | 80708 | 34861840 |
| Cerebral venous thrombosis | 51.38 | 22.62 | 17 | 14366 | 737 | 34941811 |
| Septic shock | 49.19 | 22.62 | 98 | 14285 | 71736 | 34870812 |
| Bone marrow failure | 48.50 | 22.62 | 60 | 14323 | 29193 | 34913355 |
| Blood culture positive | 48.34 | 22.62 | 28 | 14355 | 4755 | 34937793 |
| Myelosuppression | 48.24 | 22.62 | 49 | 14334 | 19216 | 34923332 |
| Bacteraemia | 47.29 | 22.62 | 49 | 14334 | 19668 | 34922880 |
| Antithrombin III decreased | 46.29 | 22.62 | 13 | 14370 | 321 | 34942227 |
| Drug ineffective | 45.42 | 22.62 | 74 | 14309 | 456677 | 34485871 |
| Pyrexia | 45.41 | 22.62 | 262 | 14121 | 332751 | 34609797 |
| Fungal infection | 44.48 | 22.62 | 43 | 14340 | 15892 | 34926656 |
| Oesophageal stenosis | 44.13 | 22.62 | 19 | 14364 | 1711 | 34940837 |
| Hepatomegaly | 42.88 | 22.62 | 35 | 14348 | 10361 | 34932187 |
| Acute lymphocytic leukaemia recurrent | 42.32 | 22.62 | 22 | 14361 | 3022 | 34939526 |
| Gastrointestinal wall thickening | 40.02 | 22.62 | 17 | 14366 | 1481 | 34941067 |
| Lipase increased | 39.47 | 22.62 | 32 | 14351 | 9384 | 34933164 |
| Escherichia infection | 38.81 | 22.62 | 30 | 14353 | 8215 | 34934333 |
| Neurotoxicity | 38.31 | 22.62 | 42 | 14341 | 17968 | 34924580 |
| Product dose omission issue | 37.93 | 22.62 | 3 | 14380 | 119708 | 34822840 |
| Pseudomonas test positive | 37.59 | 22.62 | 15 | 14368 | 1114 | 34941434 |
| Steatohepatitis | 37.42 | 22.62 | 11 | 14372 | 321 | 34942227 |
| Fatigue | 35.90 | 22.62 | 61 | 14322 | 370592 | 34571956 |
| Mucormycosis | 35.59 | 22.62 | 25 | 14358 | 5917 | 34936631 |
| Periorbital infection | 35.50 | 22.62 | 9 | 14374 | 148 | 34942400 |
| Escherichia bacteraemia | 35.28 | 22.62 | 20 | 14363 | 3260 | 34939288 |
| Intussusception | 33.99 | 22.62 | 12 | 14371 | 634 | 34941914 |
| Antithrombin III deficiency | 33.52 | 22.62 | 8 | 14375 | 101 | 34942447 |
| Thrombocytopenia | 33.45 | 22.62 | 140 | 14243 | 156107 | 34786441 |
| Atypical haemolytic uraemic syndrome | 33.28 | 22.62 | 10 | 14373 | 315 | 34942233 |
| Respiratory distress | 32.40 | 22.62 | 55 | 14328 | 35610 | 34906938 |
| Aspergillus infection | 32.20 | 22.62 | 32 | 14351 | 12222 | 34930326 |
| Escherichia sepsis | 31.02 | 22.62 | 21 | 14362 | 4683 | 34937865 |
| Candida infection | 30.43 | 22.62 | 37 | 14346 | 17678 | 34924870 |
| Parainfluenzae virus infection | 29.75 | 22.62 | 17 | 14366 | 2813 | 34939735 |
| Dyspnoea | 29.62 | 22.62 | 70 | 14313 | 376712 | 34565836 |
| Hypoalbuminaemia | 28.73 | 22.62 | 30 | 14353 | 12144 | 34930404 |
| Vascular access complication | 28.54 | 22.62 | 9 | 14374 | 334 | 34942214 |
| Mixed anxiety and depressive disorder | 28.40 | 22.62 | 7 | 14376 | 102 | 34942446 |
| Neutropenic colitis | 28.09 | 22.62 | 17 | 14366 | 3127 | 34939421 |
| Mucosal infection | 27.56 | 22.62 | 8 | 14375 | 223 | 34942325 |
| Osteonecrosis | 27.05 | 22.62 | 32 | 14351 | 14858 | 34927690 |
| Depression | 26.79 | 22.62 | 4 | 14379 | 97094 | 34845454 |
| Condition aggravated | 26.57 | 22.62 | 24 | 14359 | 192172 | 34750376 |
| Cytomegalovirus hepatitis | 25.89 | 22.62 | 9 | 14374 | 454 | 34942094 |
| Gamma-glutamyltransferase increased | 25.13 | 22.62 | 44 | 14339 | 29187 | 34913361 |
| Insomnia | 25.02 | 22.62 | 6 | 14377 | 103901 | 34838647 |
| Pancytopenia | 25.00 | 22.62 | 91 | 14292 | 95066 | 34847482 |
| Overdose | 24.56 | 22.62 | 4 | 14379 | 91055 | 34851493 |
| Prothrombin level abnormal | 24.43 | 22.62 | 6 | 14377 | 86 | 34942462 |
| Stomatitis | 24.41 | 22.62 | 54 | 14329 | 42460 | 34900088 |
| Multiple lentigines syndrome | 24.12 | 22.62 | 5 | 14378 | 31 | 34942517 |
| Clostridium difficile colitis | 24.05 | 22.62 | 31 | 14352 | 15699 | 34926849 |
| Hypersensitivity | 23.92 | 22.62 | 67 | 14316 | 60968 | 34881580 |
| Haemophagocytic lymphohistiocytosis | 23.76 | 22.62 | 28 | 14355 | 12945 | 34929603 |
| Acral lentiginous melanoma | 23.73 | 22.62 | 5 | 14378 | 34 | 34942514 |
| Lewis-Sumner syndrome | 23.73 | 22.62 | 5 | 14378 | 34 | 34942514 |
| Enterocolitis infectious | 22.85 | 22.62 | 12 | 14371 | 1683 | 34940865 |
| Meningitis bacterial | 22.74 | 22.62 | 11 | 14372 | 1296 | 34941252 |
| Optic nerve disorder | 22.62 | 22.62 | 9 | 14374 | 663 | 34941885 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Febrile neutropenia | 1763.92 | 23.07 | 1003 | 22951 | 229996 | 79490438 |
| Febrile bone marrow aplasia | 655.33 | 23.07 | 216 | 23738 | 12804 | 79707630 |
| Hypertriglyceridaemia | 595.89 | 23.07 | 200 | 23754 | 12540 | 79707894 |
| Hypofibrinogenaemia | 527.04 | 23.07 | 122 | 23832 | 1880 | 79718554 |
| Hyperbilirubinaemia | 306.86 | 23.07 | 149 | 23805 | 24369 | 79696065 |
| Secondary immunodeficiency | 300.69 | 23.07 | 86 | 23868 | 3148 | 79717286 |
| Bacterial infection | 261.57 | 23.07 | 145 | 23809 | 31135 | 79689299 |
| Neutropenia | 243.10 | 23.07 | 361 | 23593 | 287349 | 79433085 |
| Pancreatitis | 242.26 | 23.07 | 185 | 23769 | 68390 | 79652044 |
| Mucosal inflammation | 234.82 | 23.07 | 189 | 23765 | 75391 | 79645043 |
| Mycobacterium chelonae infection | 182.93 | 23.07 | 55 | 23899 | 2401 | 79718033 |
| Pseudomonal sepsis | 182.48 | 23.07 | 69 | 23885 | 6105 | 79714329 |
| Blood culture positive | 181.78 | 23.07 | 75 | 23879 | 8354 | 79712080 |
| Rhinovirus infection | 165.55 | 23.07 | 69 | 23885 | 7884 | 79712550 |
| Human bocavirus infection | 162.52 | 23.07 | 39 | 23915 | 706 | 79719728 |
| Posterior reversible encephalopathy syndrome | 161.97 | 23.07 | 100 | 23854 | 26181 | 79694253 |
| Superior sagittal sinus thrombosis | 153.57 | 23.07 | 40 | 23914 | 1023 | 79719411 |
| Clostridium difficile colitis | 150.26 | 23.07 | 103 | 23851 | 32180 | 79688254 |
| Sepsis | 144.33 | 23.07 | 276 | 23678 | 269152 | 79451282 |
| Parainfluenzae virus infection | 141.25 | 23.07 | 56 | 23898 | 5626 | 79714808 |
| Venoocclusive liver disease | 133.72 | 23.07 | 67 | 23887 | 11704 | 79708730 |
| Pyrexia | 130.48 | 23.07 | 473 | 23481 | 678236 | 79042198 |
| Colitis | 126.66 | 23.07 | 132 | 23822 | 73175 | 79647259 |
| Blood fibrinogen decreased | 124.79 | 23.07 | 39 | 23915 | 1940 | 79718494 |
| Anaphylactic reaction | 118.93 | 23.07 | 136 | 23818 | 83607 | 79636827 |
| Thymus hypoplasia | 118.58 | 23.07 | 32 | 23922 | 941 | 79719493 |
| Septic shock | 116.42 | 23.07 | 163 | 23791 | 122638 | 79597796 |
| Pancreatitis acute | 111.20 | 23.07 | 103 | 23851 | 49501 | 79670933 |
| Enterobacter infection | 110.05 | 23.07 | 44 | 23910 | 4518 | 79715916 |
| Hyperglycaemia | 109.76 | 23.07 | 120 | 23834 | 70215 | 79650219 |
| Drug ineffective | 109.18 | 23.07 | 99 | 23855 | 1080814 | 78639620 |
| Mucormycosis | 107.51 | 23.07 | 52 | 23902 | 8417 | 79712017 |
| Coagulopathy | 107.42 | 23.07 | 88 | 23866 | 35918 | 79684516 |
| Lymphoid tissue hypoplasia | 105.93 | 23.07 | 29 | 23925 | 901 | 79719533 |
| Cystitis bacterial | 103.94 | 23.07 | 27 | 23927 | 683 | 79719751 |
| Viral infection | 103.61 | 23.07 | 93 | 23861 | 42923 | 79677511 |
| Norovirus test positive | 100.92 | 23.07 | 26 | 23928 | 636 | 79719798 |
| Aspergillus infection | 100.84 | 23.07 | 66 | 23888 | 19095 | 79701339 |
| Human herpesvirus 6 infection | 99.82 | 23.07 | 43 | 23911 | 5327 | 79715107 |
| Lipase increased | 99.78 | 23.07 | 62 | 23892 | 16404 | 79704030 |
| Pneumatosis intestinalis | 95.73 | 23.07 | 44 | 23910 | 6353 | 79714081 |
| Bacteraemia | 93.28 | 23.07 | 78 | 23876 | 32746 | 79687688 |
| Blood bilirubin increased | 93.07 | 23.07 | 107 | 23847 | 66125 | 79654309 |
| Pseudomonas test positive | 90.20 | 23.07 | 30 | 23924 | 1822 | 79718612 |
| Bone marrow failure | 90.01 | 23.07 | 93 | 23861 | 51014 | 79669420 |
| Hepatotoxicity | 89.63 | 23.07 | 93 | 23861 | 51259 | 79669175 |
| Cerebral venous sinus thrombosis | 87.75 | 23.07 | 31 | 23923 | 2260 | 79718174 |
| Fungal infection | 84.62 | 23.07 | 82 | 23872 | 41666 | 79678768 |
| Fatigue | 83.64 | 23.07 | 94 | 23860 | 929633 | 78790801 |
| Antithrombin III decreased | 82.91 | 23.07 | 21 | 23933 | 479 | 79719955 |
| Tachycardia | 81.71 | 23.07 | 171 | 23783 | 177597 | 79542837 |
| Thrombocytopenia | 81.49 | 23.07 | 218 | 23736 | 265041 | 79455393 |
| Abscess bacterial | 81.22 | 23.07 | 23 | 23931 | 811 | 79719623 |
| Acute lymphocytic leukaemia recurrent | 78.63 | 23.07 | 35 | 23919 | 4689 | 79715745 |
| Intracardiac thrombus | 78.56 | 23.07 | 34 | 23920 | 4259 | 79716175 |
| Neurotoxicity | 73.79 | 23.07 | 68 | 23886 | 32450 | 79687984 |
| Pancytopenia | 73.34 | 23.07 | 157 | 23797 | 165588 | 79554846 |
| Lentigo | 73.09 | 23.07 | 19 | 23935 | 482 | 79719952 |
| Myelosuppression | 72.16 | 23.07 | 74 | 23880 | 40222 | 79680212 |
| Cholestasis | 71.21 | 23.07 | 83 | 23871 | 52026 | 79668408 |
| Hepatocellular injury | 70.43 | 23.07 | 79 | 23875 | 47514 | 79672920 |
| Bronchopulmonary aspergillosis | 69.68 | 23.07 | 56 | 23898 | 22238 | 79698196 |
| Perineal necrosis | 67.86 | 23.07 | 14 | 23940 | 121 | 79720313 |
| Leukoencephalopathy | 66.90 | 23.07 | 37 | 23917 | 7892 | 79712542 |
| Alanine aminotransferase increased | 66.26 | 23.07 | 149 | 23805 | 162421 | 79558013 |
| Pyomyositis | 64.33 | 23.07 | 18 | 23936 | 607 | 79719827 |
| Hypoalbuminaemia | 63.40 | 23.07 | 52 | 23902 | 21245 | 79699189 |
| Device related infection | 63.26 | 23.07 | 64 | 23890 | 34230 | 79686204 |
| Abdominal pain | 61.83 | 23.07 | 256 | 23698 | 389313 | 79331121 |
| Drug intolerance | 60.63 | 23.07 | 5 | 23949 | 264114 | 79456320 |
| Hepatomegaly | 60.24 | 23.07 | 48 | 23906 | 18826 | 79701608 |
| Fall | 60.21 | 23.07 | 36 | 23918 | 487593 | 79232841 |
| Viraemia | 60.06 | 23.07 | 25 | 23929 | 2844 | 79717590 |
| Hypotension | 59.72 | 23.07 | 276 | 23678 | 440041 | 79280393 |
| Clostridium test positive | 59.68 | 23.07 | 32 | 23922 | 6422 | 79714012 |
| Enteritis | 59.63 | 23.07 | 43 | 23911 | 14540 | 79705894 |
| Oesophageal candidiasis | 59.13 | 23.07 | 36 | 23918 | 9182 | 79711252 |
| Condition aggravated | 59.12 | 23.07 | 39 | 23915 | 501085 | 79219349 |
| Seizure | 57.74 | 23.07 | 155 | 23799 | 188679 | 79531755 |
| Vomiting | 57.60 | 23.07 | 369 | 23585 | 665459 | 79054975 |
| Neutrophil count decreased | 56.11 | 23.07 | 101 | 23853 | 93858 | 79626576 |
| Ascites | 55.40 | 23.07 | 89 | 23865 | 75473 | 79644961 |
| Cerebral venous thrombosis | 54.32 | 23.07 | 23 | 23931 | 2730 | 79717704 |
| Cytomegalovirus chorioretinitis | 52.96 | 23.07 | 28 | 23926 | 5462 | 79714972 |
| Potentiating drug interaction | 52.90 | 23.07 | 33 | 23921 | 8786 | 79711648 |
| Coronavirus infection | 52.56 | 23.07 | 31 | 23923 | 7466 | 79712968 |
| Diffuse alveolar damage | 51.46 | 23.07 | 24 | 23930 | 3580 | 79716854 |
| Pain | 51.16 | 23.07 | 83 | 23871 | 703719 | 79016715 |
| Arthralgia | 51.06 | 23.07 | 58 | 23896 | 571745 | 79148689 |
| Nasopharyngitis | 50.32 | 23.07 | 8 | 23946 | 253873 | 79466561 |
| Human rhinovirus test positive | 49.95 | 23.07 | 14 | 23940 | 475 | 79719959 |
| Hepatic steatosis | 49.71 | 23.07 | 59 | 23895 | 37679 | 79682755 |
| Blood lactic acid increased | 48.53 | 23.07 | 36 | 23918 | 12708 | 79707726 |
| Escherichia bacteraemia | 48.29 | 23.07 | 28 | 23926 | 6534 | 79713900 |
| Atrial fibrillation | 47.55 | 23.07 | 3 | 23951 | 197883 | 79522551 |
| Candida infection | 47.48 | 23.07 | 58 | 23896 | 38156 | 79682278 |
| Malaise | 46.72 | 23.07 | 47 | 23907 | 489822 | 79230612 |
| Neutropenic colitis | 46.42 | 23.07 | 26 | 23928 | 5681 | 79714753 |
| Disseminated aspergillosis | 46.16 | 23.07 | 16 | 23938 | 1102 | 79719332 |
| Cytomegalovirus viraemia | 46.12 | 23.07 | 35 | 23919 | 12786 | 79707648 |
| Death | 45.82 | 23.07 | 62 | 23892 | 566452 | 79153982 |
| Staphylococcal bacteraemia | 45.38 | 23.07 | 34 | 23920 | 12184 | 79708250 |
| Fusarium infection | 45.33 | 23.07 | 18 | 23936 | 1814 | 79718620 |
| Mucosal infection | 44.67 | 23.07 | 13 | 23941 | 506 | 79719928 |
| Peripheral swelling | 44.30 | 23.07 | 13 | 23941 | 269604 | 79450830 |
| Enterovirus infection | 44.27 | 23.07 | 18 | 23936 | 1929 | 79718505 |
| Oesophageal stenosis | 44.26 | 23.07 | 23 | 23931 | 4331 | 79716103 |
| Cerebral thrombosis | 43.99 | 23.07 | 19 | 23935 | 2368 | 79718066 |
| Dyspnoea | 43.97 | 23.07 | 123 | 23831 | 856902 | 78863532 |
| Aplasia | 43.75 | 23.07 | 28 | 23926 | 7792 | 79712642 |
| Overdose | 43.65 | 23.07 | 3 | 23951 | 184203 | 79536231 |
| Perineal infection | 43.03 | 23.07 | 14 | 23940 | 793 | 79719641 |
| Gastroenteritis norovirus | 42.24 | 23.07 | 20 | 23934 | 3086 | 79717348 |
| Urinary tract infection | 41.99 | 23.07 | 15 | 23939 | 274497 | 79445937 |
| Respiratory distress | 41.78 | 23.07 | 68 | 23886 | 58271 | 79662163 |
| Hyperammonaemia | 41.49 | 23.07 | 31 | 23923 | 11062 | 79709372 |
| Venous thrombosis | 41.11 | 23.07 | 26 | 23928 | 7090 | 79713344 |
| Hepatic failure | 39.37 | 23.07 | 68 | 23886 | 61144 | 79659290 |
| Pneumonia fungal | 39.00 | 23.07 | 30 | 23924 | 11180 | 79709254 |
| Bacillus test positive | 38.96 | 23.07 | 9 | 23945 | 137 | 79720297 |
| Escherichia test positive | 38.81 | 23.07 | 19 | 23935 | 3156 | 79717278 |
| Tachypnoea | 38.76 | 23.07 | 48 | 23906 | 32015 | 79688419 |
| Myocardial infarction | 38.35 | 23.07 | 5 | 23949 | 184124 | 79536310 |
| Enterocolitis | 38.18 | 23.07 | 33 | 23921 | 14479 | 79705955 |
| Intussusception | 37.94 | 23.07 | 14 | 23940 | 1156 | 79719278 |
| Therapeutic product effect decreased | 37.87 | 23.07 | 3 | 23951 | 163860 | 79556574 |
| Abdominal discomfort | 37.84 | 23.07 | 14 | 23940 | 250713 | 79469721 |
| Escherichia infection | 37.65 | 23.07 | 36 | 23918 | 17981 | 79702453 |
| Transverse sinus thrombosis | 37.35 | 23.07 | 12 | 23942 | 653 | 79719781 |
| Multiple organ dysfunction syndrome | 37.02 | 23.07 | 99 | 23855 | 120147 | 79600287 |
| Osteonecrosis | 36.71 | 23.07 | 46 | 23908 | 31049 | 79689385 |
| Platelet count decreased | 36.55 | 23.07 | 135 | 23819 | 194529 | 79525905 |
| Insomnia | 36.48 | 23.07 | 14 | 23940 | 245156 | 79475278 |
| Enterococcus test positive | 36.34 | 23.07 | 16 | 23938 | 2088 | 79718346 |
| Muscle spasms | 35.78 | 23.07 | 5 | 23949 | 174725 | 79545709 |
| Dizziness | 35.53 | 23.07 | 65 | 23889 | 526376 | 79194058 |
| Streptococcus test positive | 35.39 | 23.07 | 16 | 23938 | 2222 | 79718212 |
| Haemophagocytic lymphohistiocytosis | 35.33 | 23.07 | 38 | 23916 | 21799 | 79698635 |
| Pancreatitis necrotising | 35.08 | 23.07 | 19 | 23935 | 3889 | 79716545 |
| Fungaemia | 34.87 | 23.07 | 20 | 23934 | 4571 | 79715863 |
| Enterocolitis infectious | 34.56 | 23.07 | 17 | 23937 | 2852 | 79717582 |
| Brain oedema | 34.10 | 23.07 | 40 | 23914 | 25223 | 79695211 |
| Pulmonary haemorrhage | 33.81 | 23.07 | 31 | 23923 | 14686 | 79705748 |
| Pleural effusion | 32.70 | 23.07 | 107 | 23847 | 145155 | 79575279 |
| Hypophagia | 32.64 | 23.07 | 53 | 23901 | 45314 | 79675120 |
| Herpes simplex | 32.64 | 23.07 | 28 | 23926 | 12159 | 79708275 |
| Neuropathy peripheral | 32.63 | 23.07 | 105 | 23849 | 141200 | 79579234 |
| Escherichia sepsis | 32.32 | 23.07 | 24 | 23930 | 8484 | 79711950 |
| Drug interaction | 31.98 | 23.07 | 47 | 23907 | 415136 | 79305298 |
| Renal replacement therapy | 31.94 | 23.07 | 8 | 23946 | 174 | 79720260 |
| Hyperglycaemic hyperosmolar nonketotic syndrome | 31.84 | 23.07 | 15 | 23939 | 2288 | 79718146 |
| Disseminated intravascular coagulation | 31.59 | 23.07 | 46 | 23908 | 35796 | 79684638 |
| Depression | 31.23 | 23.07 | 13 | 23941 | 216777 | 79503657 |
| Pruritus | 31.05 | 23.07 | 44 | 23910 | 394604 | 79325830 |
| Systemic candida | 30.25 | 23.07 | 21 | 23933 | 6685 | 79713749 |
| Oral herpes | 29.86 | 23.07 | 39 | 23915 | 27415 | 79693019 |
| Antithrombin III deficiency | 29.69 | 23.07 | 7 | 23947 | 117 | 79720317 |
| Intentional product use issue | 29.66 | 23.07 | 5 | 23949 | 152107 | 79568327 |
| Tumour lysis syndrome | 29.19 | 23.07 | 36 | 23918 | 23903 | 79696531 |
| Gamma-glutamyltransferase increased | 29.14 | 23.07 | 56 | 23898 | 54624 | 79665810 |
| Steatohepatitis | 29.02 | 23.07 | 11 | 23943 | 979 | 79719455 |
| Hypoxia | 28.80 | 23.07 | 82 | 23872 | 103161 | 79617273 |
| Rhinocerebral mucormycosis | 28.31 | 23.07 | 11 | 23943 | 1047 | 79719387 |
| Respiratory failure | 27.92 | 23.07 | 118 | 23836 | 180793 | 79539641 |
| Stomatococcal infection | 27.85 | 23.07 | 8 | 23946 | 297 | 79720137 |
| Musculoskeletal stiffness | 27.73 | 23.07 | 9 | 23945 | 174999 | 79545435 |
| Apnoea | 27.57 | 23.07 | 25 | 23929 | 11679 | 79708755 |
| Perirectal abscess | 27.32 | 23.07 | 13 | 23941 | 2028 | 79718406 |
| Soft tissue infection | 26.96 | 23.07 | 16 | 23938 | 3896 | 79716538 |
| Respiratory syncytial virus test positive | 26.79 | 23.07 | 8 | 23946 | 341 | 79720093 |
| Pulse absent | 26.63 | 23.07 | 23 | 23931 | 10080 | 79710354 |
| Vascular access complication | 26.50 | 23.07 | 13 | 23941 | 2169 | 79718265 |
| Peripheral motor neuropathy | 26.47 | 23.07 | 15 | 23939 | 3352 | 79717082 |
| Antithrombin III | 26.25 | 23.07 | 6 | 23948 | 87 | 79720347 |
| Stomatitis | 26.06 | 23.07 | 100 | 23854 | 146657 | 79573777 |
| Hypogonadism | 26.00 | 23.07 | 12 | 23942 | 1748 | 79718686 |
| Weight increased | 25.96 | 23.07 | 27 | 23927 | 277359 | 79443075 |
| Anorectal cellulitis | 25.93 | 23.07 | 6 | 23948 | 92 | 79720342 |
| Intracranial hypotension | 25.40 | 23.07 | 8 | 23946 | 408 | 79720026 |
| Cholangitis infective | 25.32 | 23.07 | 9 | 23945 | 668 | 79719766 |
| Atypical haemolytic uraemic syndrome | 25.05 | 23.07 | 10 | 23944 | 1022 | 79719412 |
| Diarrhoea | 24.81 | 23.07 | 159 | 23795 | 880330 | 78840104 |
| Mental status changes | 24.64 | 23.07 | 59 | 23895 | 66900 | 79653534 |
| Lewis-Sumner syndrome | 24.58 | 23.07 | 5 | 23949 | 40 | 79720394 |
| Wound | 24.56 | 23.07 | 3 | 23951 | 116176 | 79604258 |
| Cellulitis | 24.23 | 23.07 | 80 | 23874 | 108980 | 79611454 |
| Coronavirus test positive | 24.18 | 23.07 | 10 | 23944 | 1119 | 79719315 |
| Cytomegalovirus hepatitis | 24.03 | 23.07 | 9 | 23945 | 775 | 79719659 |
| Pulmonary mucormycosis | 23.88 | 23.07 | 10 | 23944 | 1155 | 79719279 |
| Product use issue | 23.80 | 23.07 | 17 | 23937 | 209805 | 79510629 |
| Acral lentiginous melanoma | 23.67 | 23.07 | 5 | 23949 | 49 | 79720385 |
| Unresponsive to stimuli | 23.67 | 23.07 | 52 | 23902 | 55736 | 79664698 |
| Interstitial lung disease | 23.58 | 23.07 | 3 | 23951 | 112597 | 79607837 |
| Leukaemic infiltration | 23.48 | 23.07 | 6 | 23948 | 142 | 79720292 |
| Enterovirus test positive | 23.45 | 23.07 | 7 | 23947 | 298 | 79720136 |
| Rash | 23.39 | 23.07 | 92 | 23862 | 578266 | 79142168 |
| Quadriparesis | 23.30 | 23.07 | 14 | 23940 | 3487 | 79716947 |
None
| Source | Code | Description |
|---|---|---|
| ATC | L01XX24 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Other antineoplastic agents |
| FDA CS | M0001815 | Asparaginase |
| MeSH PA | D000970 | Antineoplastic Agents |
| FDA EPC | N0000175669 | Asparagine-specific Enzyme |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Acute lymphoid leukemia | indication | 91857003 | DOID:9952 |
None
None
None
None
None
None
| ID | Source |
|---|---|
| 7D96IR0PPM | UNII |
| D05387 | KEGG_DRUG |
| 4020867 | VANDF |
| C0071568 | UMLSCUI |
| CHEMBL2108546 | ChEMBL_ID |
| 436058 | PUBCHEM_CID |
| DB00059 | DRUGBANK_ID |
| 6665 | INN_ID |
| C042705 | MESH_SUPPLEMENTAL_RECORD_UI |
| 224911 | RXNORM |
| 11316 | MMSL |
| 5239 | MMSL |
| d04247 | MMSL |
| 004476 | NDDF |
| 108814000 | SNOMEDCT_US |
| 416337002 | SNOMEDCT_US |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| LYOPHILIZED PEGASPARGASE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 72694-313 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 750 [iU] | INTRAVENOUS | EXPORT ONLY | 1 sections |
| ONCASPAR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 72694-954 | INJECTION, SOLUTION | 750 [iU] | INTRAVENOUS | BLA | 31 sections |
| ONCASPAR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 72694-954 | INJECTION, SOLUTION | 750 [iU] | INTRAVENOUS | BLA | 31 sections |
| ONCASPAR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 72694-954 | INJECTION, SOLUTION | 750 [iU] | INTRAVENOUS | BLA | 31 sections |