carindacillin indications/contra

Stem definitionDrug idCAS RN
antibiotics, 6-aminopenicillanic acid derivatives 508 35531-88-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carindacillin
  • carbenicillin indanyl
  • carbenicillin indanyl ester
  • cardinacillin
  • indanyl carbenicillin
  • carbenicillin indanyl sodium
  • carindacillin sodium
  • CP-15464-2
acid stable indanyl ester of carbenicillin for oral use; same side-effects as carbenicillin; minor descriptor (75-86); on line & INDEX MEDICUS search CARBENICILLIN/AA (75-86); RN given refers to (mono-Na salt(2S-(2alpha,5alpha,6beta))-isomer)
  • Molecular weight: 494.56
  • Formula: C26H26N2O6S
  • CLOGP: 4.18
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 2
  • TPSA: 113.01
  • ALOGS: -5
  • ROTB: 7

Drug dosage:

DoseUnitRoute
4 g O

Approvals:

DateAgencyCompanyOrphan
Oct. 26, 1972 FDA PFIZER

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature baby 19.99 0 3 3 7250 3378603

Pharmacologic Action:

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SourceCodeDescription
ATC J01CA05 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
BETA-LACTAM ANTIBACTERIALS, PENICILLINS
Penicillins with extended spectrum
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Bacterial urinary infection indication 312124009

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.79 acidic
pKa2 10.77 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Bacterial penicillin-binding protein Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

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IDSource
4018408 VUID
N0000146734 NUI
C0142817 UMLSCUI
D01283 KEGG_DRUG
4OUL81K2RT UNII
26605-69-6 SECONDARY_CAS_RN
3405 INN_ID
93184 PUBCHEM_CID
CHEMBL1596 ChEMBL_ID
CHEMBL1200991 ChEMBL_ID
C100244 MESH_SUPPLEMENTAL_RECORD_UI
DB00578 DRUGBANK_ID
CHEBI:52015 CHEBI

Pharmaceutical products:

None