mepolizumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
humanized origin 5061 196078-29-2

Description:

MoleculeDescription

Synonyms:

  • mepolizumab
  • nucala
  • SB 240563
  • SB-240563
Mepolizumab is an interleukin-5 antagonist (IgG1 kappa). IL-5 is the major cytokine responsible for the growth and differentiation, recruitment, activation, and survival of eosinophils. Mepolizumab binds to IL-5 with a dissociation constant of 100 pM, inhibiting the bioactivity of IL-5 by blocking its binding to the alpha chain of the IL-5 receptor complex expressed on the eosinophil cell surface.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3.60 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 2, 2015 EMA GlaxoSmithKline Trading Services
Nov. 4, 2015 FDA GLAXOSMITHKLINE LLC
March 28, 2016 PMDA GlaxoSmithKline K.K.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Wheezing 2481.60 21.70 1136 32023 94459 63361404
Sleep disorder due to a general medical condition 1661.31 21.70 493 32666 11695 63444168
Full blood count abnormal 1418.47 21.70 556 32603 31161 63424702
Obstructive airways disorder 1412.26 21.70 495 32664 20204 63435659
Therapeutic product effect incomplete 1398.05 21.70 847 32312 124209 63331654
Dyspnoea 1134.09 21.70 1543 31616 659770 62796093
Loss of personal independence in daily activities 1091.34 21.70 661 32498 96629 63359234
Cough 732.27 21.70 829 32330 291914 63163949
Productive cough 658.07 21.70 410 32749 62798 63393065
Sputum discoloured 556.68 21.70 236 32923 16111 63439752
Nasal polyps 444.40 21.70 153 33006 5886 63449977
Chest discomfort 435.54 21.70 400 32759 109569 63346294
Eosinophilia 402.69 21.70 209 32950 22547 63433316
Upper-airway cough syndrome 392.52 21.70 166 32993 11252 63444611
Exposure via skin contact 383.29 21.70 78 33081 327 63455536
Eosinophil count increased 372.75 21.70 158 33001 10770 63445093
Bronchial secretion retention 308.20 21.70 96 33063 2677 63453186
Reversible airways obstruction 279.14 21.70 81 33078 1761 63454102
Asthmatic crisis 262.71 21.70 77 33082 1736 63454127
Asthma 257.69 21.70 325 32834 127236 63328627
Pulmonary mass 248.56 21.70 152 33007 22444 63433419
Nasal congestion 244.51 21.70 231 32928 65429 63390434
Dyspnoea exertional 235.78 21.70 218 32941 60084 63395779
Rhinitis allergic 234.44 21.70 117 33042 11610 63444253
Bronchiectasis 226.11 21.70 127 33032 16015 63439848
Product complaint 221.82 21.70 116 33043 12693 63443170
Respiratory tract infection 214.70 21.70 176 32983 41307 63414556
Vital capacity decreased 209.70 21.70 64 33095 1664 63454199
Asthma-chronic obstructive pulmonary disease overlap syndrome 198.59 21.70 64 33095 1997 63453866
Sputum culture positive 191.41 21.70 63 33096 2104 63453759
Breath sounds abnormal 186.09 21.70 98 33061 10875 63444988
Eosinophil count abnormal 184.76 21.70 46 33113 542 63455321
Diarrhoea 179.55 21.70 75 33084 715291 62740572
Total lung capacity increased 175.66 21.70 60 33099 2250 63453613
Pulmonary function test abnormal 164.85 21.70 54 33105 1776 63454087
Multiple allergies 157.29 21.70 95 33064 13707 63442156
Product dose omission issue 153.85 21.70 362 32797 233951 63221912
Blood test abnormal 151.37 21.70 97 33062 15532 63440331
Wrong technique in device usage process 149.74 21.70 60 33099 3538 63452325
Pneumonia 136.17 21.70 534 32625 456233 62999630
Ear pruritus 134.08 21.70 57 33102 3908 63451955
Bronchial obstruction 133.86 21.70 44 33115 1463 63454400
Respiratory symptom 126.21 21.70 52 33107 3295 63452568
Bronchial wall thickening 126.07 21.70 42 33117 1457 63454406
Total lung capacity decreased 125.26 21.70 46 33113 2137 63453726
Sarcoidosis 121.87 21.70 64 33095 7058 63448805
Bronchopulmonary aspergillosis allergic 120.09 21.70 45 33114 2213 63453650
Bacterial disease carrier 118.78 21.70 39 33120 1292 63454571
Middle insomnia 116.36 21.70 76 33083 12567 63443296
Rales 116.06 21.70 76 33083 12621 63443242
Chest X-ray abnormal 113.98 21.70 53 33106 4496 63451367
Sneezing 110.73 21.70 85 33074 18133 63437730
Off label use 110.51 21.70 114 33045 674348 62781515
Acute kidney injury 109.99 21.70 7 33152 263408 63192455
Rhinitis 106.26 21.70 69 33090 11297 63444566
Nausea 103.01 21.70 181 32978 854290 62601573
Lung opacity 102.03 21.70 44 33115 3124 63452739
Bronchospasm 101.49 21.70 79 33080 17201 63438662
Cardiac murmur 97.55 21.70 72 33087 14480 63441383
Prolonged expiration 97.34 21.70 32 33127 1064 63454799
Toxicity to various agents 96.38 21.70 9 33150 247241 63208622
Chronic obstructive pulmonary disease 94.89 21.70 139 33020 62547 63393316
Sputum purulent 93.59 21.70 31 33128 1056 63454807
Vocal cord dysfunction 91.12 21.70 26 33133 531 63455332
Gastrooesophageal reflux disease 90.85 21.70 172 32987 95467 63360396
Sinus disorder 88.67 21.70 85 33074 24468 63431395
Drug interaction 87.57 21.70 9 33150 229122 63226741
Factor V Leiden mutation 87.48 21.70 21 33138 210 63455653
Rhinorrhoea 87.33 21.70 137 33022 65440 63390423
Superinfection 86.57 21.70 37 33122 2570 63453293
Accidental exposure to product 84.41 21.70 87 33072 27318 63428545
Chronic sinusitis 80.42 21.70 61 33098 12782 63443081
Heart sounds 80.17 21.70 27 33132 969 63454894
Blood immunoglobulin E increased 78.68 21.70 39 33120 3810 63452053
Hospitalisation 78.32 21.70 151 33008 84930 63370933
Kyphosis 77.63 21.70 34 33125 2506 63453357
Dehydration 77.43 21.70 3 33156 173351 63282512
Alopecia 77.24 21.70 40 33119 337496 63118367
Contraindicated product administered 77.14 21.70 11 33148 217637 63238226
Asthma exercise induced 75.99 21.70 20 33139 298 63455565
Eosinophilic granulomatosis with polyangiitis 75.73 21.70 32 33127 2160 63453703
Broncholithiasis 75.54 21.70 19 33140 234 63455629
Vomiting 75.29 21.70 110 33049 559507 62896356
Lymph node calcification 75.14 21.70 20 33139 312 63455551
Blood lactic acid increased 73.65 21.70 46 33113 7040 63448823
Laryngeal stenosis 70.41 21.70 25 33134 1053 63454810
Decreased appetite 68.26 21.70 23 33136 251029 63204834
Lower respiratory tract infection 67.48 21.70 186 32973 132121 63323742
Neutropenia 66.52 21.70 7 33152 174998 63280865
Secretion discharge 65.56 21.70 53 33106 12178 63443685
Confusional state 65.42 21.70 21 33138 236359 63219504
Mycobacterium avium complex infection 65.24 21.70 32 33127 3056 63452807
Hypotension 64.30 21.70 31 33128 272573 63183290
Swelling 63.92 21.70 32 33127 275346 63180517
Abdominal discomfort 62.34 21.70 46 33113 320839 63135024
Increased bronchial secretion 61.74 21.70 26 33133 1740 63454123
Rheumatoid arthritis 59.65 21.70 29 33130 253790 63202073
Infusion related reaction 59.32 21.70 27 33132 245494 63210369
Pulmonary function test decreased 57.83 21.70 32 33127 3915 63451948
Hypomania 55.68 21.70 37 33122 6293 63449570
Respiration abnormal 55.23 21.70 37 33122 6380 63449483
Peak expiratory flow rate decreased 54.40 21.70 18 33141 611 63455252
Jaundice cholestatic 53.09 21.70 38 33121 7286 63448577
Social problem 53.09 21.70 19 33140 819 63455044
Sinus operation 52.26 21.70 26 33133 2560 63453303
Influenza 51.65 21.70 149 33010 108573 63347290
Pemphigus 51.39 21.70 16 33143 183710 63272153
Respiratory tract inflammation 51.10 21.70 17 33142 587 63455276
Sleep apnoea syndrome 50.57 21.70 69 33090 29064 63426799
Rash 49.19 21.70 141 33018 560730 62895133
Disease progression 49.07 21.70 4 33155 122754 63333109
Maternal exposure during pregnancy 48.94 21.70 27 33132 220035 63235828
Platelet count increased 48.80 21.70 53 33106 17658 63438205
Impaired quality of life 48.41 21.70 47 33112 13736 63442127
Scoliosis 48.36 21.70 37 33122 7851 63448012
Neurosensory hypoacusis 48.02 21.70 13 33146 217 63455646
Venous pressure jugular increased 47.86 21.70 16 33143 561 63455302
Lung disorder 47.20 21.70 102 33057 62159 63393704
Sputum retention 47.19 21.70 16 33143 586 63455277
Hyponatraemia 46.58 21.70 3 33156 111897 63343966
Nasopharyngitis 46.39 21.70 258 32901 253999 63201864
Joint swelling 46.36 21.70 62 33097 327604 63128259
Lung neoplasm malignant 45.99 21.70 54 33105 19579 63436284
Vasculitis 45.88 21.70 52 33107 18157 63437706
Glossodynia 45.87 21.70 18 33141 178858 63277005
Platelet count decreased 45.82 21.70 4 33155 116118 63339745
Sputum culture 45.76 21.70 13 33146 261 63455602
Mite allergy 45.75 21.70 16 33143 644 63455219
Lacrimation increased 45.46 21.70 55 33104 20576 63435287
Respiratory gas exchange disorder 45.15 21.70 14 33145 384 63455479
Arthropathy 45.13 21.70 34 33125 234758 63221105
White blood cell count decreased 44.92 21.70 9 33150 139095 63316768
Eye pruritus 44.82 21.70 52 33107 18619 63437244
Haemoglobin decreased 43.79 21.70 11 33148 145474 63310389
Depressive symptom 43.57 21.70 27 33132 4075 63451788
Pneumothorax spontaneous 42.10 21.70 16 33143 818 63455045
Emphysema 41.64 21.70 39 33120 10899 63444964
Hypercapnia 41.26 21.70 29 33130 5402 63450461
Abdominal pain 41.03 21.70 56 33103 293400 63162463
Schizophrenia 40.83 21.70 37 33122 9915 63445948
Dysphonia 40.76 21.70 82 33077 47532 63408331
Death 40.75 21.70 84 33075 374297 63081566
Upper respiratory tract infection 40.47 21.70 114 33045 81933 63373930
CFTR gene mutation 40.30 21.70 10 33149 116 63455747
Blood insulin abnormal 39.61 21.70 8 33151 32 63455831
Hand deformity 39.33 21.70 17 33142 159440 63296423
Throat clearing 39.29 21.70 21 33138 2398 63453465
Urinary tract infection 38.54 21.70 49 33110 264635 63191228
Rib fracture 38.44 21.70 53 33106 22544 63433319
Arthralgia 37.95 21.70 161 32998 569549 62886314
Stomatitis 37.17 21.70 13 33146 138712 63317151
Blister 36.84 21.70 11 33148 129803 63326060
Illness 36.75 21.70 80 33079 48979 63406884
Sinonasal obstruction 36.75 21.70 11 33148 267 63455596
Discomfort 36.53 21.70 21 33138 167353 63288510
Forced expiratory volume decreased 36.52 21.70 26 33133 4942 63450921
Oligoarthritis 36.37 21.70 13 33146 558 63455305
Systemic lupus erythematosus 35.55 21.70 34 33125 208884 63246979
Lipohypertrophy 34.44 21.70 13 33146 652 63455211
Inappropriate schedule of product administration 33.60 21.70 125 33034 103840 63352023
Appetite disorder 33.59 21.70 29 33130 7292 63448571
Synovitis 33.49 21.70 29 33130 186889 63268974
Nocturnal dyspnoea 32.98 21.70 15 33144 1209 63454654
Hypokalaemia 32.92 21.70 7 33152 103797 63352066
Blood glucose increased 32.73 21.70 3 33156 83753 63372110
Intentional product use issue 32.56 21.70 13 33146 127879 63327984
Fatigue 32.20 21.70 303 32856 887725 62568138
Nonspecific reaction 31.99 21.70 18 33141 2274 63453589
Somnolence 31.68 21.70 28 33131 178657 63277206
Haemoptysis 31.48 21.70 55 33104 28671 63427192
Tracheomalacia 31.26 21.70 9 33150 190 63455673
Blood calcium increased 31.19 21.70 31 33128 9319 63446544
Aspirin-exacerbated respiratory disease 30.70 21.70 13 33146 882 63454981
Crystal arthropathy 30.61 21.70 10 33149 326 63455537
Dust allergy 30.20 21.70 12 33147 692 63455171
Seizure 29.87 21.70 16 33143 132618 63323245
Sepsis 29.63 21.70 22 33137 153101 63302762
Aspiration 29.07 21.70 32 33127 10819 63445044
Rectal prolapse 28.84 21.70 16 33143 1967 63453896
Eye paraesthesia 28.58 21.70 8 33151 152 63455711
Forced expiratory volume abnormal 28.39 21.70 7 33152 79 63455784
Oedema 28.20 21.70 8 33151 97614 63358249
Angioplasty 28.14 21.70 14 33145 1378 63454485
Deep vein thrombosis 27.94 21.70 5 33154 83795 63372068
Treatment failure 27.78 21.70 38 33121 199005 63256858
Osteoporosis 27.62 21.70 79 33080 57259 63398604
Memory impairment 27.53 21.70 10 33149 104248 63351615
Constipation 27.50 21.70 47 33112 224896 63230967
Skin fragility 27.03 21.70 11 33148 675 63455188
Peripheral swelling 26.98 21.70 62 33097 265880 63189983
Pain 26.68 21.70 253 32906 740375 62715488
Sputum abnormal 26.28 21.70 11 33148 725 63455138
Atelectasis 26.01 21.70 43 33116 21440 63434423
FEV1/FVC ratio decreased 25.85 21.70 7 33152 117 63455746
Breast neoplasm 24.87 21.70 13 33146 1419 63454444
Treatment noncompliance 24.76 21.70 58 33101 37267 63418596
Blood pressure increased 24.72 21.70 157 33002 161905 63293958
Oropharyngeal pain 24.44 21.70 106 33053 94381 63361482
Seasonal allergy 24.12 21.70 41 33118 20909 63434954
Crepitations 23.81 21.70 25 33134 8015 63447848
Airway remodelling 23.63 21.70 6 33153 77 63455786
Cholelithiasis 23.61 21.70 63 33096 43862 63412001
Respiratory tract congestion 23.37 21.70 37 33122 17795 63438068
Irritable bowel syndrome 23.35 21.70 7 33152 82405 63373458
Anaemia 23.34 21.70 77 33082 293353 63162510
Adrenal insufficiency 23.24 21.70 37 33122 17878 63437985
Lung hyperinflation 23.19 21.70 12 33147 1283 63454580
Flail chest 23.14 21.70 6 33153 84 63455779
Therapeutic product effect decreased 23.03 21.70 41 33118 193146 63262717
Adenocarcinoma 22.99 21.70 16 33143 2934 63452929
Pericarditis 22.86 21.70 21 33138 131558 63324305
Coronavirus test positive 22.86 21.70 10 33149 735 63455128
Cardiac failure 22.79 21.70 9 33150 89133 63366730
Gastrointestinal disorder 22.74 21.70 21 33138 131218 63324645
Helicobacter infection 22.70 21.70 10 33149 92775 63363088
Lung perforation 22.64 21.70 6 33153 92 63455771
Linear IgA disease 21.91 21.70 12 33147 1439 63454424
Allergic sinusitis 21.84 21.70 11 33148 1111 63454752
Suicide attempt 21.75 21.70 3 33156 60915 63394948
Pruritus 21.71 21.70 106 33053 361347 63094516

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Wheezing 1663.19 37.22 660 16667 40742 34898862
Therapeutic product effect incomplete 1421.09 37.22 625 16702 49916 34889688
Sleep disorder due to a general medical condition 1227.11 37.22 320 17007 4901 34934703
Full blood count abnormal 919.58 37.22 346 16981 18322 34921282
Loss of personal independence in daily activities 894.07 37.22 399 16928 32780 34906824
Obstructive airways disorder 813.40 37.22 301 17026 15193 34924411
Dyspnoea 597.86 37.22 824 16503 375958 34563646
Productive cough 511.48 37.22 285 17042 37528 34902076
Cough 405.91 37.22 432 16895 149708 34789896
Asthma 294.29 37.22 210 17117 42446 34897158
Eosinophil count increased 278.86 37.22 118 17209 8454 34931150
Chest discomfort 271.50 37.22 221 17106 54309 34885295
Nasal polyps 238.15 37.22 76 17251 2427 34937177
Sputum discoloured 222.78 37.22 98 17229 7714 34931890
Chronic sinusitis 179.58 37.22 60 17267 2219 34937385
Nasal congestion 171.58 37.22 119 17208 22938 34916666
Lower respiratory tract infection 167.42 37.22 133 17194 31504 34908100
Bronchiectasis 166.19 37.22 86 17241 9715 34929889
Exposure via skin contact 160.90 37.22 29 17298 55 34939549
Breath sounds abnormal 157.26 37.22 74 17253 6807 34932797
Bronchopulmonary aspergillosis allergic 157.14 37.22 44 17283 885 34938719
Respiratory disorder 154.16 37.22 104 17223 19160 34920444
Vital capacity decreased 147.01 37.22 35 17292 357 34939247
Dyspnoea exertional 140.72 37.22 138 17189 43141 34896463
Diarrhoea 138.32 37.22 16 17311 389896 34549708
Bronchial obstruction 137.14 37.22 45 17282 1571 34938033
Blood immunoglobulin E increased 131.63 37.22 49 17278 2497 34937107
Product dose omission issue 131.02 37.22 222 17105 119489 34820115
Acute kidney injury 123.27 37.22 7 17320 304981 34634623
Chronic obstructive pulmonary disease 123.12 37.22 136 17191 48782 34890822
Eosinophilic granulomatosis with polyangiitis 112.91 37.22 41 17286 1946 34937658
Blood test abnormal 111.97 37.22 59 17268 6912 34932692
Asthma-chronic obstructive pulmonary disease overlap syndrome 109.86 37.22 36 17291 1251 34938353
Mycobacterial infection 109.37 37.22 42 17285 2332 34937272
Rhinorrhoea 108.91 37.22 95 17232 25573 34914031
Forced expiratory volume decreased 103.81 37.22 44 17283 3159 34936445
Obesity 101.75 37.22 69 17258 12809 34926795
Obstruction 100.42 37.22 41 17286 2678 34936926
Hospitalisation 98.69 37.22 131 17196 56771 34882833
Pulmonary function test abnormal 98.59 37.22 40 17287 2570 34937034
Asthmatic crisis 90.42 37.22 25 17302 479 34939125
Bronchial hyperreactivity 88.74 37.22 33 17294 1676 34937928
Bronchiolitis 87.80 37.22 39 17288 3137 34936467
Sinusitis 87.14 37.22 105 17222 41297 34898307
Eosinophil count abnormal 87.10 37.22 22 17305 292 34939312
Nausea 83.87 37.22 32 17295 339876 34599728
Upper-airway cough syndrome 83.56 37.22 39 17288 3519 34936085
Eye disorder 82.37 37.22 54 17273 9474 34930130
Reversible airways obstruction 81.97 37.22 23 17304 466 34939138
Multiple allergies 77.04 37.22 35 17292 2968 34936636
Pulmonary function test decreased 76.76 37.22 41 17286 4934 34934670
Eosinophilia 76.70 37.22 79 17248 26143 34913461
Product complaint 75.63 37.22 43 17284 5847 34933757
Respiratory symptom 72.92 37.22 29 17298 1768 34937836
Off label use 72.76 37.22 61 17266 419463 34520141
Lung disorder 69.76 37.22 86 17241 34610 34904994
Parathyroid gland enlargement 69.30 37.22 16 17311 141 34939463
Restrictive pulmonary disease 68.99 37.22 25 17302 1179 34938425
Upper respiratory fungal infection 67.76 37.22 16 17311 157 34939447
Influenza 64.95 37.22 100 17227 49566 34890038
Rhinitis 64.95 37.22 40 17287 6298 34933306
Sepsis 63.71 37.22 5 17322 166556 34773048
Secretion discharge 62.38 37.22 38 17289 5867 34933737
Rhinitis perennial 62.27 37.22 17 17310 310 34939294
Neutropenia 62 37.22 4 17323 156774 34782830
Sinus congestion 61.61 37.22 37 17290 5568 34934036
Lung diffusion disorder 59.69 37.22 14 17313 133 34939471
Pulmonary mass 59.58 37.22 50 17277 12762 34926842
Nasal disorder 57.58 37.22 25 17302 1903 34937701
Forced expiratory volume 56.47 37.22 13 17314 113 34939491
Anaemia 55.76 37.22 23 17304 233312 34706292
Foetal malformation 55.29 37.22 13 17314 125 34939479
Polyp 54.28 37.22 30 17297 3862 34935742
Snoring 52.82 37.22 28 17299 3318 34936286
Ocular discomfort 52.00 37.22 24 17303 2110 34937494
Lung diffusion test decreased 51.51 37.22 17 17310 604 34939000
Inspiratory capacity abnormal 50.61 37.22 12 17315 120 34939484
Pneumonitis 49.69 37.22 72 17255 33806 34905798
Hypotension 49.57 37.22 24 17303 221625 34717979
Lymphadenopathy 48.48 37.22 65 17262 28398 34911206
Airway remodelling 48.20 37.22 13 17314 226 34939378
Oesophageal polyp 46.96 37.22 10 17317 58 34939546
Sputum purulent 46.92 37.22 15 17312 481 34939123
Wrong technique in device usage process 46.44 37.22 20 17307 1492 34938112
Lung hyperinflation 45.34 37.22 17 17310 883 34938721
Mycobacterium test positive 45.07 37.22 14 17313 408 34939196
Eosinophilic bronchitis 44.31 37.22 12 17315 212 34939392
Adjustment disorder 43.97 37.22 18 17309 1183 34938421
Upper respiratory tract infection 42.41 37.22 66 17261 32993 34906611
Dehydration 41.98 37.22 7 17320 129962 34809642
Seasonal allergy 41.69 37.22 31 17296 6644 34932960
Bronchial disorder 41.27 37.22 18 17309 1385 34938219
Fungal disease carrier 40.96 37.22 12 17315 285 34939319
Inguinal hernia repair 40.11 37.22 12 17315 307 34939297
Nephrectomy 39.94 37.22 15 17312 783 34938821
Gastrooesophageal reflux disease 39.60 37.22 69 17258 37855 34901749
Middle insomnia 38.97 37.22 30 17297 6772 34932832
Accidental exposure to product 38.19 37.22 39 17288 12763 34926841
Vomiting 38.09 37.22 40 17287 247581 34692023

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Wheezing 3240.96 24.39 1459 40725 115205 79586999
Sleep disorder due to a general medical condition 2041.16 24.39 601 41583 13676 79688528
Full blood count abnormal 1806.57 24.39 711 41473 39763 79662441
Obstructive airways disorder 1783.21 24.39 658 41526 30801 79671403
Therapeutic product effect incomplete 1702.57 24.39 1010 41174 140635 79561569
Loss of personal independence in daily activities 1383.79 24.39 789 41395 101791 79600413
Dyspnoea 1240.11 24.39 1858 40326 855167 78847037
Productive cough 1054.45 24.39 628 41556 87703 79614501
Cough 1028.29 24.39 1109 41075 365680 79336524
Sputum discoloured 713.83 24.39 307 41877 21436 79680768
Chest discomfort 662.81 24.39 563 41621 137481 79564723
Nasal polyps 581.22 24.39 197 41987 7130 79695074
Eosinophil count increased 549.86 24.39 238 41946 16867 79685337
Upper-airway cough syndrome 450.22 24.39 185 41999 11508 79690696
Eosinophilia 393.86 24.39 264 41920 45081 79657123
Nasal congestion 360.29 24.39 309 41875 76243 79625961
Bronchiectasis 357.90 24.39 193 41991 22193 79680011
Dyspnoea exertional 337.54 24.39 315 41869 86758 79615446
Breath sounds abnormal 328.05 24.39 163 42021 15821 79686383
Asthma 325.89 24.39 379 41805 134716 79567488
Bronchial secretion retention 308.46 24.39 106 42078 3998 79698206
Vital capacity decreased 301.57 24.39 86 42098 1730 79700474
Reversible airways obstruction 290.53 24.39 87 42097 2089 79700115
Asthma-chronic obstructive pulmonary disease overlap syndrome 288.80 24.39 95 42089 3126 79699078
Asthmatic crisis 266.95 24.39 80 42104 1926 79700278
Rhinitis allergic 248.45 24.39 124 42060 12145 79690059
Diarrhoea 248.39 24.39 79 42105 880410 78821794
Pulmonary function test abnormal 242.92 24.39 89 42095 4055 79698149
Blood test abnormal 242.77 24.39 138 42046 17572 79684632
Bronchopulmonary aspergillosis allergic 241.53 24.39 82 42102 2979 79699225
Acute kidney injury 229.19 24.39 11 42173 519393 79182811
Multiple allergies 227.53 24.39 111 42073 10349 79691855
Pulmonary mass 225.88 24.39 158 42026 28876 79673328
Toxicity to various agents 203.48 24.39 4 42180 421536 79280668
Chronic obstructive pulmonary disease 201.40 24.39 237 41947 85182 79617022
Bronchial obstruction 198.36 24.39 69 42115 2699 79699505
Rhinorrhoea 194.34 24.39 220 41964 75854 79626350
Exposure via skin contact 194.11 24.39 43 42141 286 79701918
Chronic sinusitis 193.48 24.39 107 42077 12919 79689285
Drug interaction 185.66 24.39 8 42176 415175 79287029
Lower respiratory tract infection 179.48 24.39 277 41907 128943 79573261
Respiratory symptom 178.28 24.39 74 42110 4717 79697487
Total lung capacity increased 167.44 24.39 58 42126 2240 79699964
Blood immunoglobulin E increased 166.85 24.39 75 42109 5807 79696397
Respiratory tract infection 165.58 24.39 164 42020 48525 79653679
Product dose omission issue 164.10 24.39 387 41797 247150 79455054
Off label use 157.94 24.39 149 42035 907066 78795138
Eosinophil count abnormal 149.52 24.39 41 42143 710 79701494
Ear pruritus 144.53 24.39 61 42123 4054 79698150
Middle insomnia 140.49 24.39 94 42090 15975 79686229
Nausea 137.33 24.39 184 42000 957012 78745192
Sputum culture positive 135.98 24.39 57 42127 3724 79698480
Eosinophilic granulomatosis with polyangiitis 127.70 24.39 54 42130 3606 79698598
Sneezing 125.53 24.39 95 42089 19588 79682616
Gastrooesophageal reflux disease 122.23 24.39 207 41977 104039 79598165
Prolonged expiration 116.00 24.39 38 42146 1233 79700971
Lung opacity 115.81 24.39 56 42128 5118 79697086
Neutropenia 115.21 24.39 10 42174 287700 79414504
Bacterial disease carrier 112.56 24.39 39 42145 1507 79700697
Pneumonia 112.39 24.39 663 41521 659583 79042621
Influenza 110.05 24.39 224 41960 129382 79572822
Chest X-ray abnormal 109.56 24.39 62 42122 7821 79694383
Secretion discharge 105.88 24.39 77 42107 14945 79687259
Hypotension 104.85 24.39 51 42133 440266 79261938
Bronchospasm 104.11 24.39 94 42090 24765 79677439
Rales 102.76 24.39 85 42099 19916 79682288
Bronchial wall thickening 102.36 24.39 42 42142 2599 79699605
Total lung capacity decreased 101.81 24.39 43 42141 2862 79699342
Sarcoidosis 101.09 24.39 60 42124 8275 79693929
Dehydration 101.09 24.39 8 42176 248179 79454025
Obstruction 100.48 24.39 49 42135 4561 79697643
Sinus disorder 100.15 24.39 88 42096 22376 79679828
Mycobacterial infection 98.43 24.39 45 42139 3623 79698581
Respiratory disorder 98.34 24.39 120 42064 44736 79657468
Pulmonary function test decreased 97.94 24.39 57 42127 7580 79694624
Rhinitis 97.83 24.39 73 42111 14734 79687470
Death 97.20 24.39 94 42090 566420 79135784
Forced expiratory volume decreased 96.73 24.39 57 42127 7757 79694447
Vomiting 94.24 24.39 129 42055 665699 79036505
Cardiac murmur 91.36 24.39 72 42112 15752 79686452
Upper respiratory tract infection 90.07 24.39 168 42016 91000 79611204
Vasculitis 84.29 24.39 84 42100 25018 79677186
Lung disorder 84.05 24.39 152 42032 80405 79621799
Vocal cord dysfunction 83.88 24.39 25 42159 590 79701614
Bronchiolitis 83.81 24.39 42 42142 4146 79698058
Sepsis 81.49 24.39 21 42163 269407 79432797
Bronchial hyperreactivity 80.65 24.39 37 42147 3003 79699201
Heart sounds 80.63 24.39 27 42157 939 79701265
Lung diffusion disorder 80.11 24.39 19 42165 177 79702027
Sputum purulent 79.16 24.39 29 42155 1320 79700884
Kyphosis 78.52 24.39 35 42149 2656 79699548
Confusional state 78.48 24.39 35 42149 317962 79384242
Hospitalisation 77.75 24.39 161 42023 94075 79608129
Eye pruritus 76.88 24.39 73 42111 20497 79681707
Respiration abnormal 76.47 24.39 49 42135 7739 79694465
White blood cell count decreased 74.12 24.39 7 42177 188281 79513923
Decreased appetite 72.31 24.39 46 42138 342372 79359832
Broncholithiasis 71.16 24.39 18 42166 224 79701980
Nasopharyngitis 70.17 24.39 293 41891 253588 79448616
Laryngeal stenosis 69.87 24.39 25 42159 1063 79701141
Obesity 69.06 24.39 89 42095 35036 79667168
Emphysema 68.97 24.39 62 42122 16238 79685966
Increased bronchial secretion 68.45 24.39 34 42150 3293 79698911
Restrictive pulmonary disease 67.02 24.39 31 42153 2564 79699640
Illness 66.31 24.39 101 42083 46410 79655794
Haemoptysis 65.33 24.39 111 42073 55888 79646316
Product complaint 64.99 24.39 55 42129 13294 79688910
Seasonal allergy 64.72 24.39 60 42124 16346 79685858
Drug abuse 64.16 24.39 6 42178 162685 79539519
Superinfection 63.96 24.39 37 42147 4865 79697339
Urinary tract infection 62.00 24.39 34 42150 274478 79427726
Lymph node calcification 61.54 24.39 18 42166 397 79701807
Wrong technique in device usage process 59.56 24.39 33 42151 3995 79698209
Malignant neoplasm progression 59.46 24.39 3 42181 135987 79566217
Sinus operation 58.54 24.39 28 42156 2497 79699707
Dysphonia 57.65 24.39 106 42078 56766 79645438
Atelectasis 57.65 24.39 78 42106 32179 79670025
Parathyroid gland enlargement 56.52 24.39 14 42170 159 79702045
Nasal disorder 56.07 24.39 31 42153 3738 79698466
Rhinitis perennial 55.36 24.39 16 42168 338 79701866
Fungal disease carrier 55.27 24.39 16 42168 340 79701864
Seizure 54.67 24.39 16 42168 188818 79513386
Crepitations 54.45 24.39 44 42140 9973 79692231
Infusion related reaction 54.23 24.39 27 42157 230210 79471994
Airway remodelling 53.69 24.39 15 42169 279 79701925
Polyp 53.62 24.39 40 42144 8067 79694137
Anaemia 53.53 24.39 96 42088 444919 79257285
Cardiac failure 53.10 24.39 9 42175 154833 79547371
Haemoglobin decreased 52.38 24.39 26 42158 222093 79480111
Hypercapnia 52.32 24.39 41 42143 8894 79693310
Forced expiratory volume 52.12 24.39 12 42172 97 79702107
Scoliosis 49.75 24.39 37 42147 7427 79694777
Hypomania 49.40 24.39 37 42147 7507 79694697
Overdose 49.12 24.39 18 42166 184188 79518016
Blood lactic acid increased 49.10 24.39 46 42138 12698 79689506
Contraindicated product administered 48.14 24.39 12 42172 157526 79544678
Hyponatraemia 48.07 24.39 17 42167 177831 79524373
Gastrointestinal haemorrhage 47.64 24.39 10 42174 147709 79554495
Disease progression 47.52 24.39 19 42165 184343 79517861
Mycobacterium test positive 47.42 24.39 15 42169 434 79701770
Lacrimation increased 47.42 24.39 59 42125 22418 79679786
Lung hyperinflation 47.36 24.39 22 42162 1837 79700367
Cardiac arrest 47.29 24.39 16 42168 172080 79530124
Upper respiratory fungal infection 46.55 24.39 14 42170 341 79701863
Adverse drug reaction 46.27 24.39 106 42078 66286 79635918
Eosinophilic bronchitis 46.08 24.39 15 42169 477 79701727
Intentional product use issue 45.69 24.39 12 42172 152100 79550104
Polymyalgia rheumatica 45.67 24.39 29 42155 4508 79697696
Inspiratory capacity abnormal 45.41 24.39 11 42173 113 79702091
Sputum abnormal 45.25 24.39 19 42165 1246 79700958
Stomatitis 45.19 24.39 11 42173 146746 79555458
Respiratory gas exchange disorder 45.19 24.39 17 42167 834 79701370
Eye disorder 43.96 24.39 58 42126 23354 79678850
Neurosensory hypoacusis 43.22 24.39 12 42172 218 79701986
Rheumatoid arthritis 42.62 24.39 29 42155 208441 79493763
Sinus congestion 41.62 24.39 52 42132 19844 79682360
Respiratory tract inflammation 41.28 24.39 16 42168 852 79701352
Blood glucose increased 40.96 24.39 6 42178 114969 79587235
Sleep apnoea syndrome 40.82 24.39 71 42113 36407 79665797
Social problem 39.71 24.39 18 42166 1420 79700784
Asthenia 39.25 24.39 139 42045 511550 79190654
Impaired quality of life 39.09 24.39 43 42141 14343 79687861
Oesophageal polyp 39.06 24.39 9 42175 73 79702131
Inguinal hernia repair 38.94 24.39 12 42172 318 79701886
Coma 38.92 24.39 4 42180 100645 79601559
Alopecia 38.87 24.39 39 42145 231316 79470888
Oedema 38.75 24.39 8 42176 119572 79582632
Bronchial disorder 38.48 24.39 21 42163 2468 79699736
Jaundice cholestatic 38.32 24.39 38 42146 11246 79690958
Lung diffusion test decreased 38.10 24.39 17 42167 1293 79700911
Snoring 38.02 24.39 28 42156 5538 79696666
Lung neoplasm malignant 37.71 24.39 59 42125 27733 79674471
Nocturnal dyspnoea 37.60 24.39 18 42166 1608 79700596
Haemophilus infection 37.41 24.39 20 42164 2256 79699948
Fatigue 37.30 24.39 314 41870 929413 78772791
Sinusitis 36.77 24.39 202 41982 195299 79506905
Oropharyngeal pain 36.48 24.39 134 42050 109219 79592985
CFTR gene mutation 36.11 24.39 9 42175 105 79702099
Agitation 36.00 24.39 5 42179 99710 79602494
Mite allergy 35.89 24.39 16 42168 1214 79700990
Pneumonitis 35.79 24.39 91 42093 60769 79641435
Nonspecific reaction 35.41 24.39 20 42164 2512 79699692
Rash 35.10 24.39 172 42012 578186 79124018
Somnolence 35.02 24.39 45 42139 238936 79463268
Joint swelling 34.91 24.39 62 42122 288584 79413620
Sinonasal obstruction 34.69 24.39 11 42173 321 79701883
Venous pressure jugular increased 34.58 24.39 16 42168 1324 79700880
Depressed level of consciousness 34.53 24.39 5 42179 96647 79605557
Sputum retention 34.37 24.39 15 42169 1082 79701122
Peak expiratory flow rate decreased 33.94 24.39 13 42171 670 79701534
Abdominal discomfort 33.94 24.39 50 42134 250677 79451527
Malaise 33.90 24.39 402 41782 489467 79212737
Delirium 33.68 24.39 3 42181 84624 79617580
Cardio-respiratory arrest 33.67 24.39 8 42176 108502 79593702
Inappropriate schedule of product administration 33.62 24.39 150 42034 133478 79568726
Oligoarthritis 33.21 24.39 13 42171 711 79701493
Suicide attempt 32.84 24.39 3 42181 82929 79619275
Depressive symptom 32.37 24.39 27 42157 6396 79695808
Throat clearing 31.91 24.39 19 42165 2635 79699569
Appetite disorder 31.88 24.39 29 42155 7710 79694494
Abdominal pain 31.77 24.39 103 42081 389466 79312738
Intentional product misuse 31.60 24.39 6 42178 95159 79607045
Hyperventilation 31.37 24.39 29 42155 7870 79694334
Blister 31.30 24.39 12 42172 119464 79582740
Septic shock 31.08 24.39 13 42171 122788 79579416
Platelet count increased 31.00 24.39 48 42136 22358 79679846
Loss of consciousness 30.94 24.39 26 42158 167917 79534287
Rib fracture 30.76 24.39 54 42130 27893 79674311
Swelling 30.53 24.39 42 42142 216669 79485535
Pneumothorax spontaneous 30.33 24.39 15 42169 1439 79700765
Arthralgia 30.28 24.39 178 42006 571625 79130579
Vascular shunt 30.14 24.39 7 42177 59 79702145
Sputum culture 30.01 24.39 9 42175 217 79701987
Lung hernia 29.83 24.39 7 42177 62 79702142
Dyspnoea paroxysmal nocturnal 29.55 24.39 17 42167 2211 79699993
Nasal septum deviation 29.50 24.39 16 42168 1857 79700347
Hypokalaemia 29.48 24.39 20 42164 144020 79558184
Aspiration 29.04 24.39 44 42140 20114 79682090
Osteoporosis 28.84 24.39 78 42106 54034 79648170
Neuropathy peripheral 28.42 24.39 20 42164 141285 79560919
Renal impairment 28.37 24.39 25 42159 157758 79544446
Blood calcium increased 28.11 24.39 31 42153 10369 79691835
Lipohypertrophy 27.41 24.39 12 42172 872 79701332
Rectal prolapse 27.25 24.39 16 42168 2162 79700042
Schizophrenia 27.08 24.39 37 42147 15403 79686801
Angioplasty 26.83 24.39 15 42169 1848 79700356
Aspirin-exacerbated respiratory disease 26.82 24.39 13 42171 1194 79701010
Breast neoplasm 26.80 24.39 12 42172 920 79701284
Respiratory tract congestion 26.57 24.39 42 42142 19912 79682292
Memory impairment 26.44 24.39 13 42171 111721 79590483
Renal failure 26.30 24.39 41 42143 200927 79501277
Haematuria 25.94 24.39 3 42181 68833 79633371
Choking 25.91 24.39 32 42152 12069 79690135
Medication error 25.84 24.39 3 42181 68639 79633565
Ocular discomfort 25.22 24.39 21 42163 4962 79697242

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R03DX09 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Other systemic drugs for obstructive airway diseases
FDA MoA N0000191871 Interleukin-5 Antagonists
FDA EPC N0000191872 Interleukin-5 Antagonist

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Allergic granulomatosis angiitis indication 82275008 DOID:3049
Asthma indication 195967001 DOID:2841
Eosinophilic asthma indication 367542003 DOID:9498




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Interleukin-5 Cytokine ANTIBODY BINDING Kd 10 DRUG LABEL DRUG LABEL

External reference:

IDSource
90Z2UF0E52 UNII
D04923 KEGG_DRUG
4035064 VANDF
C0969324 UMLSCUI
CHEMBL2108429 ChEMBL_ID
DB06612 DRUGBANK_ID
7876 INN_ID
C434107 MESH_SUPPLEMENTAL_RECORD_UI
7685 IUPHAR_LIGAND_ID
1720597 RXNORM
237129 MMSL
27021 MMSL
d07571 MMSL
016563 NDDF
716046009 SNOMEDCT_US
781308003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Nucala HUMAN PRESCRIPTION DRUG LABEL 1 0173-0881 INJECTION, POWDER, FOR SOLUTION 100 mg SUBCUTANEOUS BLA 27 sections
Nucala HUMAN PRESCRIPTION DRUG LABEL 1 0173-0881 INJECTION, POWDER, FOR SOLUTION 100 mg SUBCUTANEOUS BLA 27 sections
Nucala HUMAN PRESCRIPTION DRUG LABEL 1 0173-0881 INJECTION, POWDER, FOR SOLUTION 100 mg SUBCUTANEOUS BLA 27 sections
Nucala HUMAN PRESCRIPTION DRUG LABEL 1 0173-0881 INJECTION, POWDER, FOR SOLUTION 100 mg SUBCUTANEOUS BLA 27 sections
Nucala HUMAN PRESCRIPTION DRUG LABEL 1 0173-0892 INJECTION, SOLUTION 100 mg SUBCUTANEOUS BLA 27 sections
Nucala HUMAN PRESCRIPTION DRUG LABEL 1 0173-0892 INJECTION, SOLUTION 100 mg SUBCUTANEOUS BLA 27 sections
Nucala HUMAN PRESCRIPTION DRUG LABEL 1 0173-0892 INJECTION, SOLUTION 100 mg SUBCUTANEOUS BLA 27 sections
Nucala HUMAN PRESCRIPTION DRUG LABEL 1 0173-0892 INJECTION, SOLUTION 100 mg SUBCUTANEOUS BLA 27 sections
Nucala HUMAN PRESCRIPTION DRUG LABEL 1 0173-0904 INJECTION, SOLUTION 40 mg SUBCUTANEOUS BLA 27 sections
Nucala HUMAN PRESCRIPTION DRUG LABEL 1 0173-0904 INJECTION, SOLUTION 40 mg SUBCUTANEOUS BLA 27 sections
Nucala HUMAN PRESCRIPTION DRUG LABEL 1 0173-0904 INJECTION, SOLUTION 40 mg SUBCUTANEOUS BLA 27 sections