carbutamide indications/contra

Stem definitionDrug idCAS RN
antihyperglycaemics 505 339-43-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carbutamide
  • nadisan
  • nadizan
  • norboral
  • aminophenurobutane
  • bucarban
  • burcol
  • butisulfina
  • carbutamid
  • glybutamide
  • sulfaninylbutylurea
  • butylcarbamide
A sulfonylurea antidiabetic agent with similar actions and uses to CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)
  • Molecular weight: 271.34
  • Formula: C11H17N3O3S
  • CLOGP: 1.02
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 3
  • TPSA: 101.29
  • ALOGS: -2.60
  • ROTB: 4

Drug dosage:

DoseUnitRoute
0.75 g O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC A10BB06 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sulfonylureas
MeSH PA D007004 Hypoglycemic Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.31 acidic
pKa2 1.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sulfonylurea receptor 1, Kir6.2 Ion channel BLOCKER Kd 4.60 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

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IDSource
N0000166471 NUI
C0007080 UMLSCUI
D02425 KEGG_DRUG
9564 PUBCHEM_CID
N0000166471 NDFRT
2068 RXNORM
005300 NDDF
CHEBI:135118 CHEBI
CHEMBL448570 ChEMBL_ID
D002271 MESH_DESCRIPTOR_UI
E3K8P4869P UNII
615 INN_ID

Pharmaceutical products:

None