carboquone indications/contra

Stem definitionDrug idCAS RN
503 24279-91-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carboquone
  • carbazilquinone
  • esquinone
An alkylating agent structurally similar to MITOMYCIN and found to be effective in the treatment of leukemia and various other neoplasms in mice. It causes leukemia and thrombocytopenia in almost all human patients.
  • Molecular weight: 321.33
  • Formula: C15H19N3O5
  • CLOGP: -1.21
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 1
  • TPSA: 101.71
  • ALOGS: -1.29
  • ROTB: 7

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

scroll-->
SourceCodeDescription
ATC L01AC03 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ALKYLATING AGENTS
Ethylene imines
MeSH PA D000477 Alkylating Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018906 Antineoplastic Agents, Alkylating
MeSH PA D009676 Noxae

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

scroll-->
Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.65 acidic
pKa2 6.32 Basic
pKa3 4.29 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

scroll-->
IDSource
D01270 KEGG_DRUG
1CB0HBT12C UNII
3651 INN_ID
N0000167146 NDFRT
CHEMBL443014 ChEMBL_ID
2569 PUBCHEM_CID
D002225 MESH_DESCRIPTOR_UI
CHEBI:31356 CHEBI

Pharmaceutical products:

None