Stem definition | Drug id | CAS RN |
---|---|---|
interleukin-11 analogues and derivatives | 5026 | 145941-26-0 |
Molecule | Description |
---|---|
Synonyms:
|
Oprelvekin is a recombinant human Interleukin-11. Interleukin eleven (IL-11) is a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.
|
Dose | Unit | Route |
---|---|---|
3.50 | mg | P |
None
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 25, 1997 | FDA | WYETH PHARMS INC |
None
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Myelosuppression | 49.04 | 39.38 | 13 | 213 | 40283 | 79703879 |
None
Source | Code | Description |
---|---|---|
ATC | L03AC02 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSTIMULANTS IMMUNOSTIMULANTS Interleukins |
FDA CS | M0021434 | Thrombopoietin |
MeSH PA | D000970 | Antineoplastic Agents |
FDA EPC | N0000175668 | Megakaryocyte Growth Factor |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Thrombocytopenic disorder | indication | 302215000 | DOID:1588 |
None
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Interleukin-11 receptor | Membrane receptor | AGONIST | DRUG LABEL | DRUG LABEL |
ID | Source |
---|---|
HM5641GA6F | UNII |
D05266 | KEGG_DRUG |
4021084 | VUID |
N0000148542 | NUI |
4021084 | VANDF |
C0537670 | UMLSCUI |
CHEMBL1201573 | ChEMBL_ID |
DB00038 | DRUGBANK_ID |
7558 | INN_ID |
C105308 | MESH_SUPPLEMENTAL_RECORD_UI |
6971 | IUPHAR_LIGAND_ID |
1311380 | RXNORM |
11470 | MMSL |
5205 | MMSL |
d04254 | MMSL |
007281 | NDDF |
108968006 | SNOMEDCT_US |
108969003 | SNOMEDCT_US |
410938009 | SNOMEDCT_US |
74138002 | SNOMEDCT_US |
146069 | PUBCHEM_CID |
None