agalsidase alfa 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
enzymes 5021 None

Description:

MoleculeDescription

Synonyms:

  • agalsidase alfa
  • replagal
  • agalsidase alfa (genetical recombination)
genetically engineered, glycosylated human alpha-galactosidase isoenzyme A used in treatment of Fabry disease
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
1 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 3, 2001 EMA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Peritonitis 55.33 49.77 10 49 17144 63471819

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Peritonitis 35.93 35.47 10 286 28026 79716066

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A16AB03 ALIMENTARY TRACT AND METABOLISM
OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
Enzymes

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Fabry's disease indication 16652001 DOID:14499




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02784 KEGG_DRUG
104138-64-9 SECONDARY_CAS_RN
CHEMBL2108214 ChEMBL_ID
C000627036 MESH_SUPPLEMENTAL_RECORD_UI
DB15874 DRUGBANK_ID
008578 NDDF
423634009 SNOMEDCT_US
424905009 SNOMEDCT_US
C0962517 UMLSCUI
8048 INN_ID
2HLC17MX9G UNII

Pharmaceutical products:

None