carboprost indications/contra

Stem definitionDrug idCAS RN
prostaglandins 502 35700-23-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carboprost
  • carboprost tromethamine
  • carboprost trometamol
A nonsteroidal abortifacient agent that is effective in both the first and second trimesters of PREGNANCY.
  • Molecular weight: 368.51
  • Formula: C21H36O5
  • CLOGP: 2.67
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 4
  • TPSA: 97.99
  • ALOGS: -3.72
  • ROTB: 12

Drug dosage:

DoseUnitRoute
2.50 mg P

Approvals:

DateAgencyCompanyOrphan
Jan. 9, 1979 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC G02AD04 GENITO URINARY SYSTEM AND SEX HORMONES
OTHER GYNECOLOGICALS
UTEROTONICS
Prostaglandins
FDA EPC N0000175454 Prostaglandin Analog
FDA Chemical/Ingredient N0000007706 Prostaglandins
MeSH PA D000019 Abortifacient Agents
MeSH PA D000020 Abortifacient Agents, Nonsteroidal
MeSH PA D010120 Oxytocics
MeSH PA D012102 Reproductive Control Agents
CHEBI has role CHEBI:36063 oxytocic
CHEBI has role CHEBI:50691 abortifacient

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Postpartum hemorrhage indication 47821001
Pregnancy with abortive outcome indication 363681007
Hyperbilirubinemia contraindication 14783006 DOID:2741
Disorder of lung contraindication 19829001 DOID:850
Hypertensive disorder contraindication 38341003 DOID:10763
Mild pre-eclampsia contraindication 41114007
Third trimester pregnancy contraindication 41587001
Low blood pressure contraindication 45007003
Severe pre-eclampsia contraindication 46764007 DOID:10591
Heart disease contraindication 56265001 DOID:114
Acute nephropathy contraindication 58574008
Diabetes mellitus contraindication 73211009 DOID:9351
Stenosis of cervix contraindication 83536006
Epilepsy contraindication 84757009 DOID:1826
Kidney disease contraindication 90708001 DOID:2527
Asthma contraindication 195967001 DOID:2841
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Inflammatory Disease of Female Pelvic Organs contraindication
Gynecological Surgery contraindication
Incomplete miscarriage off-label use 156072005
Induction of labor off-label use 236958009
Cervical ripening procedure off-label use 236959001
Hydatidiform mole, benign off-label use 417044008 DOID:3590

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.79 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin F2-alpha receptor GPCR AGONIST CHEMBL CHEMBL

External reference:

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IDSource
DB00429 DRUGBANK_ID
4018095 VUID
N0000146433 NUI
C0007047 UMLSCUI
D00682 KEGG_DRUG
7B5032XT6O UNII
4044 INN_ID
4018095 VANDF
N0000005780 NDFRT
N0000146433 NDFRT
2051 RXNORM
109057004 SNOMEDCT_US
373455002 SNOMEDCT_US
d00588 MMSL
004942 NDDF
5281075 PUBCHEM_CID
CHEMBL1237105 ChEMBL_ID
CHEMBL1237122 ChEMBL_ID
D002260 MESH_DESCRIPTOR_UI
58551-69-2 SECONDARY_CAS_RN
C062843 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:3403 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Hemabate HUMAN PRESCRIPTION DRUG LABEL 1 0009-0856 INJECTION, SOLUTION 250 ug INTRAMUSCULAR NDA 11 sections