aceprometazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
50 13461-01-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • aceprometazine
  • acepromethazine
  • aceprometazine maleate
  • Molecular weight: 326.46
  • Formula: C19H22N2OS
  • CLOGP: 4.38
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 23.55
  • ALOGS: -4.43
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D015259 Dopamine Agents
MeSH PA D018492 Dopamine Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:35474 anti-anxiety agents
CHEBI has role CHEBI:35717 hypnotics
CHEBI has role CHEBI:37956 antihistamines

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Insomnia indication 193462001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic
pKa2 1.82 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
161203 RXNORM
C0608826 UMLSCUI
CHEBI:53770 CHEBI
CHEMBL2104054 ChEMBL_ID
DB01615 DRUGBANK_ID
C021280 MESH_SUPPLEMENTAL_RECORD_UI
26035 PUBCHEM_CID
1921 INN_ID
7455-18-7 SECONDARY_CAS_RN
984N9YTM4Y UNII
005488 NDDF
005489 NDDF

Pharmaceutical products:

None