aceprometazine indications/contra

Stem definitionDrug idCAS RN
50 13461-01-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • aceprometazine
  • acepromethazine
  • aceprometazine maleate
  • Molecular weight: 326.46
  • Formula: C19H22N2OS
  • CLOGP: 4.38
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 23.55
  • ALOGS: -4.43
  • ROTB: 4

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35717 sedative
CHEBI has role CHEBI:37956 histamine antagonist
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D015259 Dopamine Agents
MeSH PA D018492 Dopamine Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Insomnia indication 193462001

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic
pKa2 1.82 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST DRUG LABEL DRUG LABEL

External reference:

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IDSource
C0608826 UMLSCUI
161203 RXNORM
005488 NDDF
984N9YTM4Y UNII
1921 INN_ID
7455-18-7 SECONDARY_CAS_RN
26035 PUBCHEM_CID
C021280 MESH_SUPPLEMENTAL_RECORD_UI
DB01615 DRUGBANK_ID
CHEMBL2104054 ChEMBL_ID
CHEBI:53770 CHEBI

Pharmaceutical products:

None