carbinoxamine indications/contra

Stem definitionDrug idCAS RN
antihistaminics 499 486-16-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carbinoxamine tannate
  • carbinoxamine
  • carbinoxamine maleate
  • paracarinoxamine
  • paracarbinoxamine
  • carbinoxamine diphenyldisulfonate
antihistamine with anticholinergic and sedative properties
  • Molecular weight: 290.79
  • Formula: C16H19ClN2O
  • CLOGP: 2.67
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 25.36
  • ALOGS: -3.11
  • ROTB: 6

Drug dosage:

DoseUnitRoute
16 mg O

Approvals:

DateAgencyCompanyOrphan
Dec. 27, 1974 FDA MCNEIL

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC R06AA08 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Aminoalkyl ethers
FDA MoA N0000000190 Histamine H1 Receptor Antagonists
FDA EPC N0000175587 Histamine-1 Receptor Antagonist
CHEBI has role CHEBI:37955 H1-receptor antagonist
CHEBI has role CHEBI:50857 anti-allergic agent
CHEBI has role CHEBI:48876 muscarinic antagonist
CHEBI has role CHEBI:48407 antiparkinson drug
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Dermatographic urticaria indication 7632005 DOID:743
Vasomotor rhinitis indication 8229003 DOID:4730
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Common cold indication 82272006 DOID:10459
Urticaria indication 126485001
Seasonal allergic rhinitis indication 367498001
Itching of skin indication 418363000
Allergic conjunctivitis indication 473460002 DOID:11204
Brain damage contraindication 2470005
Ocular hypertension contraindication 4210003 DOID:9282
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcohol withdrawal delirium contraindication 8635005
Peptic ulcer contraindication 13200003 DOID:750
Asthenia contraindication 13791008
Severe chronic ulcerative colitis contraindication 14311001
Constipation contraindication 14760008 DOID:2089
Mood swings contraindication 18963009
Myocardial infarction contraindication 22298006 DOID:5844
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Hypercapnia contraindication 29596007
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Hypothyroidism contraindication 40930008 DOID:1459
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acidosis contraindication 51387008
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Paralytic ileus contraindication 55525008 DOID:8442
Peptic reflux disease contraindication 57643001 DOID:13976
Ulcerative colitis contraindication 64766004 DOID:8577
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Arteriosclerotic vascular disease contraindication 72092001 DOID:2349
Diabetes mellitus contraindication 73211009 DOID:9351
Urethral stricture contraindication 76618002
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Cor pulmonale contraindication 83291003 DOID:8515
Hiatal hernia contraindication 84089009 DOID:12642
Pulmonary emphysema contraindication 87433001
Kidney disease contraindication 90708001 DOID:2527
Myasthenia gravis contraindication 91637004 DOID:437
Acute abdominal pain contraindication 116290004
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
Seizure disorder contraindication 128613002 DOID:1826
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Drug-induced psychosis contraindication 191483003 DOID:1742
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Myocardial dysfunction contraindication 233928007
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Pyloric obstruction contraindication 244815007 DOID:3122
Benign prostatic hyperplasia contraindication 266569009 DOID:2883
Retention of urine contraindication 267064002
Drowsy contraindication 271782001
Exacerbation of asthma contraindication 281239006
Lesion of brain contraindication 301766008
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000 DOID:13774
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Disorder of coronary artery contraindication 414024009
Central nervous system depression contraindication 418072004
Dysfunction of sphincter of Oddi contraindication 430887001
Hypertensive urgency contraindication 443482000

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.79 Basic
pKa2 4.21 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST CHEMBL CHEMBL

External reference:

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IDSource
C1331203 UMLSCUI
7139 IUPHAR_LIGAND_ID
D01336 KEGG_DRUG
02O55696WH UNII
3505-38-2 SECONDARY_CAS_RN
DB00748 DRUGBANK_ID
CHEMBL864 ChEMBL_ID
2564 PUBCHEM_CID
4019656 VANDF
72187 MMSL
N0000147748 NDFRT
N0000006898 NDFRT
d03569 MMSL
20220 RXNORM
372896001 SNOMEDCT_US
90882008 SNOMEDCT_US
004790 NDDF
359 INN_ID
CHEBI:3398 CHEBI
CHEMBL1200974 ChEMBL_ID
C004649 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Karbinal HUMAN PRESCRIPTION DRUG LABEL 1 13551-101 SUSPENSION, EXTENDED RELEASE 4 mg ORAL NDA 17 sections
RyVent HUMAN PRESCRIPTION DRUG LABEL 1 15370-130 TABLET 6 mg ORAL ANDA 11 sections
carbinoxamine maleate HUMAN PRESCRIPTION DRUG LABEL 1 44523-825 TABLET 4 mg ORAL ANDA 11 sections
carbinoxamine maleate HUMAN PRESCRIPTION DRUG LABEL 1 46672-191 TABLET 4 mg ORAL ANDA 11 sections
carbinoxamine maleate HUMAN PRESCRIPTION DRUG LABEL 1 46672-644 SYRUP 4 mg ORAL ANDA 11 sections
carbinoxamine maleate HUMAN PRESCRIPTION DRUG LABEL 1 46672-857 TABLET 6 mg ORAL ANDA 11 sections
Carbinoxamine Maleate HUMAN PRESCRIPTION DRUG LABEL 1 51991-333 TABLET 4 mg ORAL ANDA 13 sections
Carbinoxamine Maleate HUMAN PRESCRIPTION DRUG LABEL 1 51991-334 SYRUP 4 mg ORAL ANDA 13 sections
Carbinoxamine Maleate HUMAN PRESCRIPTION DRUG LABEL 1 64376-605 TABLET 4 mg ORAL ANDA 11 sections
Carbinoxamine Maleate HUMAN PRESCRIPTION DRUG LABEL 1 64376-612 SOLUTION 4 mg ORAL ANDA 11 sections
Carbinoxamine Maleate HUMAN PRESCRIPTION DRUG LABEL 1 69067-240 TABLET 6 mg ORAL ANDA 12 sections